Slow-roll Inflation with the Gauss-Bonnet and Chern-Simons Corrections

We study slow-roll inflation with the Gauss-Bonnet and Chern-Simons corrections. We obtain general formulas for the observables: spectral indices, tensor-to-scalar ratio and circular polarization of gravitational waves. The Gauss-Bonnet term violates the consistency relation r = -8n_T. Particularly, blue spectrum n_T > 0 and scale invariant spectrum |8n_T|/r << 1 of tensor modes are possible. These cases require the Gauss-Bonnet coupling function of \xi _{,\phi } \sim 10^8/M_{Pl}. We use examples to show new-inflation-type potential with 10M_{Pl} symmetry breaking scale and potential with flat region in \phi \gtrsim 10M_{Pl} lead to observationally consistent blue and scale invariant spectra, respectively. Hence, these interesting cases can actually be realized. The Chern-Simons term produce circularly polarized tensor modes. We show an observation of these signals supports existence of the Chern-Simons coupling function of \omega _{,\phi } \sim 10^8/M_{Pl}. Thus, with future observations, we can fix or constrain the value of these coupling functions, at the CMB scale.Comment: 21 pages, 5 figure

An Efficient Algorithm for Enumerating Chordless Cycles and Chordless Paths

A chordless cycle (induced cycle) $C$ of a graph is a cycle without any chord, meaning that there is no edge outside the cycle connecting two vertices of the cycle. A chordless path is defined similarly. In this paper, we consider the problems of enumerating chordless cycles/paths of a given graph $G=(V,E),$ and propose algorithms taking $O(|E|)$ time for each chordless cycle/path. In the existing studies, the problems had not been deeply studied in the theoretical computer science area, and no output polynomial time algorithm has been proposed. Our experiments showed that the computation time of our algorithms is constant per chordless cycle/path for non-dense random graphs and real-world graphs. They also show that the number of chordless cycles is much smaller than the number of cycles. We applied the algorithm to prediction of NMR (Nuclear Magnetic Resonance) spectra, and increased the accuracy of the prediction

Superconductivity induced by longitudinal ferromagnetic fluctuations in UCoGe

From detailed angle-resolved NMR and Meissner measurements on a ferromagnetic (FM) superconductor UCoGe (T_Curie ~ 2.5 K and T_SC ~ 0.6 K), we show that superconductivity in UCoGe is tightly coupled with longitudinal FM spin fluctuations along the c axis. We found that magnetic fields along the c axis (H || c) strongly suppress the FM fluctuations and that the superconductivity is observed in the limited magnetic field region where the longitudinal FM spin fluctuations are active. These results combined with model calculations strongly suggest that the longitudinal FM spin fluctuations tuned by H || c induce the unique spin-triplet superconductivity in UCoGe. This is the first clear example that FM fluctuations are intimately related with superconductivity.Comment: 4 pages, 5 figures, to appear in PR

Discovery of TUG-770: a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist for treatment of type 2 diabetes

Free fatty acid receptor 1 (FFA1 or GPR40) enhances glucose-stimulated insulin secretion from pancreatic β-cells and currently attracts high interest as a new target for the treatment of type 2 diabetes. We here report the discovery of a highly potent FFA1 agonist with favorable physicochemical and pharmacokinetic properties. The compound efficiently normalizes glucose tolerance in diet-induced obese mice, an effect that is fully sustained after 29 days of chronic dosing

A Note on Scalar Field Theory in AdS_3/CFT_2

We consider a scalar field theory in AdS_{d+1}, and introduce a formalism on surfaces at equal values of the radial coordinate. In particular, we define the corresponding conjugate momentum. We compute the Noether currents for isometries in the bulk, and perform the asymptotic limit on the corresponding charges. We then introduce Poisson brackets at the border, and show that the asymptotic values of the bulk scalar field and the conjugate momentum transform as conformal fields of scaling dimensions \Delta_{-} and \Delta_{+}, respectively, where \Delta_{\pm} are the standard parameters giving the asymptotic behavior of the scalar field in AdS. Then we consider the case d=2, where we obtain two copies of the Virasoro algebra, with vanishing central charge at the classical level. An AdS_3/CFT_2 prescription, giving the commutators of the boundary CFT in terms of the Poisson brackets at the border, arises in a natural way. We find that the boundary CFT is similar to a generalized ghost system. We introduce two different ground states, and then compute the normal ordering constants and quantum central charges, which depend on the mass of the scalar field and the AdS radius. We discuss certain implications of the results.Comment: 24 pages. v2: added minor clarification. v3: added several comments and discussions, abstract sligthly changed. Version to be publishe

Anisotropic magnetic fluctuations in the ferromagnetic superconductor UCoGe studied by angle-resolved ^{59}Co NMR

We have carried out direction-dependent ^{59}Co NMR experiments on a single crystal sample of the ferromagnetic superconductor UCoGe in order to study the magnetic properties in the normal state. The Knight shift and nuclear spin-lattice relaxation rate measurements provide microscopic evidence that both static and dynamic susceptibilities are ferromagnetic with strong Ising anisotropy. We discuss that superconductivity induced by these magnetic fluctuations prefers spin-triplet pairing state.Comment: 4 pages, 4 figure

Vertebrate Lrig3-ErbB Interactions Occur In Vitro but Are Unlikely to Play a Role in Lrig3-Dependent Inner Ear Morphogenesis

Background: The Lrig genes encode a family of transmembrane proteins that have been implicated in tumorigenesis, psoriasis, neural crest development, and complex tissue morphogenesis. Whether these diverse phenotypes reflect a single underlying cellular mechanism is not known. However, Lrig proteins contain evolutionarily conserved ectodomains harboring both leucine-rich repeats and immunoglobulin domains, suggesting an ability to bind to common partners. Previous studies revealed that Lrig1 binds to and inhibits members of the ErbB family of receptor tyrosine kinases by inducing receptor internalization and degradation. In addition, other receptor tyrosine kinase binding partners have been identified for both Lrig1 and Lrig3, leaving open the question of whether defective ErbB signaling is responsible for the observed mouse phenotypes. Methodology/Principal Findings: Here, we report that Lrig3, like Lrig1, is able to interact with ErbB receptors in vitro. We examined the in vivo significance of these interactions in the inner ear, where Lrig3 controls semicircular canal formation by determining the timing and extent of Netrin1 expression in the otic vesicle epithelium. We find that ErbB2 and ErbB3 are present in the early otic epithelium, and that Lrig3 acts cell-autonomously here, as would be predicted if Lrig3 regulates ErbB2/B3 activity. However, inhibition of ErbB activation in the chick otic vesicle has no detectable effect on Netrin gene expression or canal morphogenesis. Conclusions/Significance: Our results suggest that although both Lrig1 and Lrig3 can interact with ErbB receptors in vitro, modulation of Neuregulin signaling is unlikely to contribute to Lrig3-dependent processes of inner ear morphogenesis. These results highlight the similar binding properties of Lrig1 and Lrig3 and underscore the need to determine how these two family members bind to and regulate different receptors to affect diverse aspects of cell behavior in vivo

Decoupled and inhomogeneous gas flows in S0 galaxies

A recent analysis of the "Einstein" sample of early-type galaxies has revealed that at any fixed optical luminosity Lb S0 galaxies have lower mean X-ray luminosity Lx per unit Lb than ellipticals. Following a previous analytical investigation of this problem (Ciotti & Pellegrini 1996), we have performed 2D numerical simulations of the gas flows inside S0 galaxies in order to ascertain the effectiveness of rotation and/or galaxy flattening in reducing the Lx/Lb ratio. The flow in models without SNIa heating is considerably ordered, and essentially all the gas lost by the stars is cooled and accumulated in the galaxy center. If rotation is present, the cold material settles in a disk on the galactic equatorial plane. Models with a time decreasing SNIa heating host gas flows that can be much more complex. After an initial wind phase, gas flows in energetically strongly bound galaxies tend to reverse to inflows. This occurs in the polar regions, while the disk is still in the outflow phase. In this phase of strong decoupling, cold filaments are created at the interface between inflowing and outflowing gas. Models with more realistic values of the dynamical quantities are preferentially found in the wind phase with respect to their spherical counterparts of equal Lb. The resulting Lx of this class of models is lower than in spherical models with the same Lb and SNIa heating. At variance with cooling flow models, rotation is shown to have only a marginal effect in this reduction, while the flattening is one of the driving parameters for such underluminosity, in accordance with the analytical investigation.Comment: 32 pages LaTex file, plus 5 .ps figures and macro aasms4.sty -- Accepted on Ap