PICA communicating artery aneurysm

This report presents a rare case of such an aneurysm arising from such a communicating artery. A 66-year-old woman presented with a subarachnoid hemorrhage located predominantly in the cisterna magna with intraventricular hemorrhage. Angiography showed hypoplasia of the right posterior inferior cerebellar artery. Its vermian territory was supplied by the communicating artery from the posterior medullary segments of the left posterior inferior cerebellar artery. An aneurysm was on that communicating artery itself at a nonbranching site. The aneurysm was trapped the next day. Postoperative computed tomography showed no infarct in the right posterior inferior cerebellar artery territory. Trapping is applicable when other collateral vessels supply the contralateral posterior inferior cerebellar artery territory

Transposon mediated transgenesis in a marine invertebrate chordate: Ciona intestinalis

Achievement of transposon mediated germline transgenesis in a basal chordate, Ciona intestinalis, is discussed. A Tc1/mariner superfamily transposon, Minos, has excision and transposition activities in Ciona. Minos enables the creation of stable transgenic lines, enhancer detection, and insertional mutagenesis

ALMA Detection of 321 GHz water maser emission in the radio galaxy NGC 1052

The Atacama Large Millimeter/submillimeter Array (ALMA) serendipitously detected H$_2$O $J_{Ka, Kc} = 10_{2,9} - 9_{3,6}$ emission at 321 GHz in NGC 1052. This is the first submillimeter maser detection in a radio galaxy and the most luminous 321-GHz H$_2$O maser known to date with the isotropic luminosity of 1090 $L_{\odot}$. The line profile consists of a broad velocity component with FWHM $= 208 \pm 12$ km s$^{-1}$ straddling the systemic velocity and a narrow component with FWHM $= 44 \pm 3$ km s$^{-1}$ blueshifted by 160 km s$^{-1}$. The profile is significantly different from the known 22-GHz $6_{1,6} - 5_{2,3}$ maser which shows a broad profile redshifted by 193 km s$^{-1}$. The submillimeter maser is spatially unresolved with a synthesized beam of $0^{\prime \prime}.68 \times 0^{\prime \prime}.56$ and coincides with the continuum core position within 12 pc. These results indicate amplification of the continuum emission through high-temperature ($>1000$ K) and dense ($n({\rm H}_2{\rm O}) > 10^4$ cm$^{-3}$) molecular gas in front of the coreComment: 3 figures, Accepted for publication in Publications of Astronomical Society of Japa

HOW TREATMENT CHANGES SLEEP APNEA SYNDROME IN PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION

Digitalitzat per Artypla

A Novel RNA Synthesis Inhibitor, STK160830, Has Negligible DNA-Intercalating Activity for Triggering A p53 Response, and Can Inhibit p53-Dependent Apoptosis

RNA synthesis inhibitors and protein synthesis inhibitors are useful for investigating whether biological events with unknown mechanisms require transcription or translation; however, the dependence of RNA synthesis has been difficult to verify because many RNA synthesis inhibitors cause adverse events that trigger a p53 response. In this study, we screened a library containing 9600 core compounds and obtained STK160830 that shows anti-apoptotic effects in irradiated wild-type-p53-bearing human T-cell leukemia MOLT-4 cells and murine thymocytes. In many of the p53-impaired cells and p53-knockdown cells tested, STK160830 did not show a remarkable anti-apoptotic effect, suggesting that the anti-apoptotic activity is p53-dependent. In the expression analysis of p53, p53-target gene products, and reference proteins by immunoblotting, STK160830 down-regulated the expression of many of the proteins examined, and the downregulation correlated strongly with its inhibitory effect on cell death. mRNA expression analyses by qPCR and nascent RNA capture kit revealed that STK160830 showed a decreased mRNA expression, which was similar to that induced by the RNA synthesis inhibitor actinomycin D but differed to some extent. Furthermore, unlike other RNA synthesis inhibitors such as actinomycin D, p53 accumulation by STK160830 alone was negligible, and a DNA melting-curve analysis showed very weak DNA-intercalating activity, indicating that STK160830 is a useful inhibitor for RNA synthesis without triggering p53-mediated damage responses

Radioprotection by p53 Regulatory Agents

Radiation damage to normal tissues is one of the most serious concerns in radiation therapy, and the tolerance dose of the normal tissues limits the therapeutic dose to the patients. p53 is well known as a transcription factor closely associated with radiation-induced cell death. We recently demonstrated the protective effects of several p53 regulatory agents against low-LET X- or γ-ray-induced damage. Although it was reported that high-LET heavy ion radiation (>85 keV/μm) could cause p53-independent cell death in some cancer cell lines, whether there is any radioprotective effect of the p53 regulatory agents against the high-LET radiation injury in vivo is still unclear. In the present study, we verified the efficacy of these agents on bone marrow and intestinal damages induced by high-LET heavy-ion irradiation in mice. We used a carbon-beam (14 keV/μm) that was shown to induce a p53-dependent effect and an iron-beam (189 keV/μm) that was shown to induce a p53-independent effect in a previous study. Vanadate significantly improved 60-day survival rate in mice treated with total-body carbon-ion (p < 0.0001) or iron-ion (p < 0.05) irradiation, indicating its effective protection of the hematopoietic system from radiation injury after high-LET irradiation over 85 keV/μm. 5CHQ also significantly increased the survival rate after abdominal carbon-ion (p < 0.02), but not iron-ion irradiation, suggesting the moderate relief of the intestinal damage. These results demonstrated the effectiveness of p53 regulators on acute radiation syndrome induced by high-LET radiation