3,194 research outputs found

    Dark energy from dark radiation in strongly coupled cosmologies with no fine tuning

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    A dual component made of non-relativistic particles and a scalar field, exchanging energy, naturally falls onto an attractor solution, making them a (sub)dominant part of the cosmic energy during the radiation dominated era, provided that the constant \beta, measuring the coupling, is strong enough. The density parameters of both components are then constant, as they expand as a^{-4}. If the field energy is then prevalently kinetic, as is expected, its energy is exactly half of the pressureless component; the dual component as a whole, then, has a density parameter \Omega_{cd} = 3/4\beta^2 (e.g., for \beta~2.5, \Omega_{cd}~0.1, in accordance with Dark Radiation expectations). The stationary evolution can only be broken by the rising of other component(s), expanding as a^{-3}. In a realistic scenario, this happens when z~3-5x10^3. When such extra component(s) become(s) dominant, the densities of the dual components also rise above radiation. The scalar field behavior can be easily tuned to fit Dark Energy data, while the coupled DM density parameter becomes O(10^{-3}). This model however requires that, at present, two different DM components exist. The one responsible for the break of the stationary regime could be made, e.g., by thermally distributed particles with mass even >>1$-2 keV (or non-thermal particles with analogous average speed) so accounting for the size of observed galactic cores; in fact, a fair amount of small scale objects is however produced by fluctuation re-generated by the coupled DM component, in spite of its small density parameter, after the warm component has become non-relativistic.Comment: 19 pages, 6 figures, JCAP publishe

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    Integrated Application of Active Controls (IAAC) technology to an advanced subsonic transpot project-demonstration act system definition

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    The 1985 ACT airplane is the Final Active Controls Technology (ACT) Airplane with the addition of three-axis fly by wire. Thus it retains all the efficiency features of the full ACT system plus the weight and cost savings accruing from deletion of the mechanical control system. The control system implements the full IAAC spectrum of active controls except flutter-mode control, judged essentially nonbeneficial, and incorporates new control surfaces called flaperons to make the most of wing-load alleviation. This redundant electronic system is conservatively designed to preserve the extreme reliability required of crucial short-period pitch augmentation, which provides more than half of the fuel savings

    Dynamics of the middle atmosphere as simulated by the Whole Atmosphere Community Climate Model, version 3 (WACCM3)

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    The Whole Atmosphere Community Climate Model, version 3 (WACCM3) is a state-of-the-art climate model extending from the Earth's surface to the lower thermosphere. In this paper we present a detailed climatology of the dynamics of the middle atmosphere as represented by WACCM3 at various horizontal resolutions and compare them to observations. In addition to the mean climatological fields, we examine in detail the middle atmospheric momentum budget as well as several lower and upper atmosphere coupling phenomena including stratospheric sudden warmings, the 2-day wave, and the migrating diurnal tide. We find that in large part, differences between WACCM3 and observations and the mean state of the model at various horizontal resolutions are related to gravity wave drag, which is parameterized in WACCM3 (and similar models). All three lower and upper atmosphere coupling processes examined show high sensitivity to the model's resolution

    Modelling the impacts of ammonia emissions reductions on North American air quality

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    A unified regional air-quality modelling system (AURAMS) was used to investigate the effects of reductions in ammonia emissions on regional air quality, with a focus on particulate-matter formation. Three simulations of one-year duration were performed for a North American domain: (1) a base-case simulation using 2002 Canadian and US national emissions inventories augmented by a more detailed Canadian emissions inventory for agricultural ammonia; (2) a 30% North-American-wide reduction in agricultural ammonia emissions; and (3) a 50% reduction in Canadian beef-cattle ammonia emissions. The simulations show that a 30% continent-wide reduction in agricultural ammonia emissions lead to reductions in median hourly PM<sub>2.5</sub> mass of <1 μg m<sup>−3</sup> on an annual basis. The atmospheric response to these emission reductions displays marked seasonal variations, and on even shorter time scales, the impacts of the emissions reductions are highly episodic: 95th-percentile hourly PM<sub>2.5</sub> mass decreases can be up to a factor of six larger than the median values. <br><br> A key finding of the modelling work is the linkage between gas and aqueous chemistry and transport; reductions in ammonia emissions affect gaseous ammonia concentrations close to the emissions site, but substantial impacts on particulate matter and atmospheric deposition often occur at considerable distances downwind, with particle nitrate being the main vector of ammonia/um transport. Ammonia emissions reductions therefore have trans-boundary consequences downwind. Calculations of critical-load exceedances for sensitive ecosystems in Canada suggest that ammonia emission reductions will have a minimal impact on current ecosystem acidification within Canada, but may have a substantial impact on future ecosystem acidification. The 50% Canadian beef-cattle ammonia emissions reduction scenario was used to examine model sensitivity to uncertainties in the new Canadian agricultural ammonia emissions inventory, and the simulation results suggest that further work is needed to improve the emissions inventory for this particular sector. It should be noted that the model in its current form neglects coarse mode base cation chemistry, so the predicted effects of ammonia emissions reductions shown here should be considered upper limits

    Biological and technical variables affecting immunoassay recovery of cytokines from human serum and simulated vaginal fluid: A multicenter study

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    The increase of proinflammatory cytokines in vaginal secretions may serve as a surrogate marker of unwanted inflammatory reaction to microbicide products topically applied for the prevention of sexually transmitted diseases, including HIV-1. Interleukin (IL)-1β and IL-6 have been proposed as indicators of inflammation and increased risk of HIV-1 transmission; however, the lack of information regarding detection platforms optimal for vaginal fluids and interlaboratory variation limit their use for microbicide evaluation and other clinical applications. This study examines fluid matrix variants relevant to vaginal sampling techniques and proposes a model for interlaboratory comparisons across current cytokine detection technologies. IL-1β and IL-6 standards were measured by 12 laboratories in four countries, using 14 immunoassays and four detection platforms based on absorbance, chemiluminescence, electrochemiluminescence, and fluorescence. International reference preparations of cytokines with defined biological activity were spiked into (1) a defined medium simulating the composition of human vaginal fluid at pH 4.5 and 7.2, (2) physiologic salt solutions (phosphate-buffered saline and saline) commonly used for vaginal lavage sampling in clinical studies of cytokines, and (3) human blood serum. Assays were assessed for reproducibility, linearity, accuracy, and significantly detectable fold difference in cytokine level. Factors with significant impact on cytokine recovery were determined by Kruskal−Wallis analysis of variance with Dunn’s multiple comparison test and multiple regression models. All assays showed acceptable intra-assay reproducibility; however, most were associated with significant interlaboratory variation. The smallest reliably detectable cytokine differences (P < 0.05) derived from pooled interlaboratory data varied from 1.5- to 26-fold depending on assay, cytokine, and matrix type. IL-6 but not IL-1β determinations were lower in both saline and phosphate-buffered saline as compared to vaginal fluid matrix, with no significant effect of pH. The (electro)chemiluminescence-based assays were most discriminative and consistently detected <2-fold differences within each matrix type. The Luminex-based assays were less discriminative with lower reproducibility between laboratories. These results suggest the need for uniform vaginal sampling techniques and a better understanding of immunoassay platform differences and cross-validation before the biological significance of cytokine variations can be validated in clinical trials. This investigation provides the first standardized analytic approach for assessing differences in mucosal cytokine levels and may improve strategies for monitoring immune responses at the vaginal mucosal interface
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