Multi-generational House

BUTOROVÁ, H.: Dvougenerační rodinný dům: Bakalářská práce. Ostrava: VŠB-Technická univerzita Ostrava, Fakulta stavební, Katedra architektury 226, 2017, 49 s. Vedoucí práce: Student, A. Předmětem bakalářské práce „Dvougenerační rodinný dům“ je vypracování částečné projektové dokumentace pro provádění stavby podle vyhlášky 499/2006 Sb., o dokumentaci staveb. Jako podklad bakalářské práce slouží architektonická studie vypracovaná v rámci předmětu Ateliérová tvorba I a dokumentace pro stavební povolení vypracovaná v předmětu Ateliérová tvorba Va. Rodinný dvougenerační dům je navržen v lázeňské oblasti Karviná-Darkov. Stavba je složena z části pro mladou rodinu a z části pro starší rodiče. Cílem bylo vytvořit společné zázemí obou rodin, avšak i dostatek soukromí. Koncepce domu je založena na přízemní části staršího páru a na dvoupodlažní části mladé čtyřčlenné rodiny.BUTOROVÁ, H.: Multi-generational House: Bachelor´s thesis. Ostrava: VŠB-Technical university of Ostrava, Faculty of Civil Engineering, Department of Architecture 226, 2017, 49 p. Thesis head: Student, A. The subject of bachelor’s thesis „Multi-generational House‟ is preparation of partial project documentation for construction of a building according to notice 499/2006 Sb., about documentation of buildings. As resource materials serves architectural study worked out from Studio Work I and a documentation for building permit worked out from Studio Work Va. Multi-generational House is projected in the spa area Karviná-Darkov. The building consists of a part for young family and a part for grandparents. The goal was to make a common base for both families, but also to secure enough privacy. The philosophy of the house is based on the ground part for older couple and on the two-floor part for young four-member family.226 - Katedra architekturyvelmi dobř

Flowchart of the study participants.

<p>Flowchart of the study participants.</p

Effect of the number of domains with problems on health indicators at 12-month follow-up (n = 2172)^*.

<p>Effect of the number of domains with problems on health indicators at 12-month follow-up (n = 2172)^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0121013#t003fn001" target="_blank">*</a>}.</p

Association between the number of domains with problems at baseline and scores on the health indicators.

<p>Association between the number of domains with problems at baseline and scores on the health indicators.</p

Baseline characteristics of the total study population and stratified for the number of domains with problems.

<p>Baseline characteristics of the total study population and stratified for the number of domains with problems.</p

Nasal Levels of Antimicrobial Peptides in Allergic Asthma Patients and Healthy Controls: Differences and Effect of a Short 1,25(OH)₂ Vitamin D3 Treatment

<div><p>Background</p><p>Allergy is often accompanied by infections and lower levels of antimicrobial peptides (AMPs). Vitamin D has been shown to increase expression of selected AMPs. In this study we investigated whether antimicrobial peptide levels in nasal secretions of allergic asthma patients are lower than in healthy controls, and whether administration of the active form of vitamin D (1,25(OH)₂D3) affects these antimicrobial peptide levels.</p><p>Methods</p><p>The levels of antimicrobial peptides in nasal secretions were compared between 19 allergic asthma patients and 23 healthy controls. The effect of seven days daily oral treatment with 2 μg 1,25(OH)₂D3 on antimicrobial peptides in nasal secretions was assessed in a placebo-controlled cross-over clinical study.</p><p>Results</p><p>Levels of neutrophil α-defensins (human neutrophil peptides 1–3; HNP1-3) and lipocalin 2 (LCN2; also known as NGAL) were significantly lower in asthmatics, but no differences in LL-37 and SLPI were detected. Treatment with a short-term 1,25(OH)₂D3 caused a small increase in HNP1-3, but not when the asthma and control groups were analyzed separately. LL-37, LCN2 and SLPI did not change after treatment with 1,25(OH)₂D3.</p><p>Conclusion</p><p>Levels of the antimicrobial peptides HNP1-3 and LCN2 are lower in nasal secretions in asthmatics and are not substantially affected by a short-term treatment with active vitamin D.</p></div

Flow diagram of tested patients.

<p>Over an eighteen month period 53 cases were contacted. The parents of five children chose not to participate. For the remaining 48 cases written informed consent was obtained. Thirty-seven of the 48 infants were seen three times. Of the remaining eleven, two were seen twice, at one week and one month, and the third visit was canceled by the parents because of good recovery. Eight were seen relatively late, so they were only seen at one and three months. One infant was only seen at one week because of good recovery afterwards. Not attended visits were regarded as missing data. The mean age at visit one was 9 days (median 9, range 12), at visit two 32 days (median 31, range 29) and at visit three 87 days (median 87, range 29).</p

The results of the ten test items at visits one (∼1 week), two (∼1 month) and three (∼3 months).

<p>For each of the ten dichotomous items concerning joint movements and needle electromyography, the sensitivity, 1- specificity and percentage of correct prediction of a ‘mild’ or ‘severe’ lesion is indicated. Electromyography (EMG): the presence of spontaneous muscle activity (fibrillation and/or positive sharp waves) and the absence of motor unit action potentials (MUPs). p values denote results from Pearson's Chi-Square test.</p

Flow diagram of LUMC validation group (n = 60).

<p>Follow-up data resulted in a severe lesion in 34 infants (57%). The three item test indicated a severe lesion in 39 infants (65%). The test predicted outcome correctly in 88% (53/60) of infants (sensitivity 0.97, specificity 0.76, PPV 0.84, NPV 0.95. The dash style of the arrows indicates related patient flows.</p

Baseline AMPs, in nasal secretions.

<p>HNP1-3, LL-37, LCN2 and SLPI in nasal secretions from atopic asthma patients and healthy controls.</p