Corporate Social Responsibility in a context of sustainable development

“The future we want”, the main document summarizing the action areas advocated by the Rio+20 conference (Rio de Janeiro, Brazil, June 20-22nd), advocates “green economy” as a main instrument to eradicate poverty, while maintaining the healthy functioning of the environment. “Green economy” is a reply to global capitalism and the excesses of its elite practitioners, as they became manifest during the recent economic crisis. A classical contribution of the private business sector to sustainable development is corporate social responsibility (CSR). The concept dovetails in the doctrine that a company is not only responsible for a positive economic performance, but also has to take care about the environmental, social and ethical aspects of its activities. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/3164

Cosmetics as endocrine disruptors: are they a health risk?

Exposure to chemicals from different sources in everyday life is widespread; one such source is the wide range of products listed under the title “cosmetics”, including the different types of popular and widely-advertised sunscreens. Women are encouraged through advertising to buy into the myth of everlasting youth, and one of the most alarming consequences is in utero exposure to chemicals. The main route of exposure is the skin, but the main endpoint of exposure is endocrine disruption. This is due to many substances in cosmetics and sunscreens that have endocrine active properties which affect reproductive health but which also have other endpoints, such as cancer. Reducing the exposure to endocrine disruptors is framed not only in the context of the reduction of health risks, but is also significant against the background and rise of ethical consumerism, and the responsibility of the cosmetics industry in this respect. Although some plants show endocrine-disrupting activity, the use of well-selected natural products might reduce the use of synthetic chemicals. Instruments dealing with this problem include life-cycle analysis, eco-design, and green labels; in combination with the committed use of environmental management systems, they contribute to “corporate social responsibility”. © 2016, Springer Science+Business Media New York

The epidemiology of neonatal tumours: Report of an international working group

Neonatal tumours occur every 12,500-27,500 live births and comprise 2% of childhood malignancies, but there is little clarity as to their real prevalence, sites of origin and pathological nature as reported series vary. As an entity, neonatal tumours provide a unique window of opportunity to study tumours in which minimal environmental interference has occurred. The majority of tumours present with a mass at birth (e.g., teratomas, neuroblastomas, mesoblastic nephroma, fibromatosis), which are not infrequently identified on antenatal ultrasound. Histologically, teratoma and neuroblastoma remain the two main tumour types encountered with soft tissue sarcoma, renal tumours, CNS tumours and leukaemia being the next most common tumour types identified. Malignant tumours are uncommon in the neonatal period per se and benign tumours may have malignant potential. A particular problem exists in clinical classification, as histological features of malignancy do not always correlate with clinical behaviour. Benign tumours may also be life threatening because of their size and location. Other tumours may demonstrate local invasiveness, but no metastatic potential, and tumours that are clearly malignant may demonstrate unpredictable or uncertain behaviour. Screening programmes have brought more tumours to light, but do not appear to affect the overall prognosis. They may provide clues to the stage at which tumours develop in foetu. The aetiology of cancer in children is multifactorial and includes both genetic and environmental factors. The association between congenital abnormalities and tumours is well established (15% of neonatal tumours). Genetic defects are highly likely in neonatal tumours and include those with a high risk of malignancy (e.g., retinoblastoma), but also genetically determined syndromes with an increased risk of malignancy and complex genetic rearrangements. Tumours are mostly genetically related at a cellular level and factors influencing cellular maturation or apoptosis within the developing foetus may continue to operate in the neonatal period. Cytogenetics of neonatal neoplasms appear to differ from neoplasms in older children, thus possibly explaining some of the observed differences in clinical behaviour. Certain constitutional chromosome anomalies, however, specifically favour tumuors occurring in the foetal and neonatal period. In support of this hypothesis, certain cytogenetic anomalies appear to be specific to neonates, and a number of examples are explored. Other environmental associations include ionizing radiation, drugs taken during pregnancy, infections, tumours in the mother and environmental exposure.Revie

Subsite-specific differences of estrogen receptor beta expression in the normal colonic epithelium: Implications for carcinogenesis and colorectal cancer epidemiology

Objective: This study aimed at investigating whether a differential estrogen receptor beta (ER-β) expression between the colonic subsites could correspond to a modification in proliferation, apoptosis, and adhesion of the normal colonocytes. Methods: ER-β, Ki-67, Bcl-2, and E-cadherin expressions were investigated immunohistochemically, in normal epithelium biopsies from the ascending and the descending colon of 53 individuals, who underwent colonoscopy for the investigation of anemia and in whom no local pathology was identified. Results: ER-β immunoreactivity has been shown to be stronger at the superficial epithelium than the crypts base, the difference being important only for the ascending colon. In addition, ER-β expression was higher in the superficial epithelium of the ascending colon than that of the descending colon. The variations of ER-β expression did not correspond to the alterations in Ki-67, Bcl-2, and E-cadherin expression. Conclusion: A subsite-specific variation of ER-β expression has been shown in the normal colonic epithelium. This modulation of ER-β might account for some well established specificities of colorectal cancer epidemiology like the right-sided predominance of the neoplasm in women and its gradual shift to more proximal sites over time. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins

Stile di vita e valutazione dell'esposizione del personale di Istituti di ricerca.

Stile di vita e valutazione dell'esposizione del personale di Istituti di ricerc