Experimental investigation of negatively buoyant sediment plumes resulting from Dredging operations

In a first step to investigate the behaviour of sediment plumes released from dredging vessels, an experimental facility has been built to release scaled fine sediment plumes in the presence of cross flow. High-frequency measurements of velocity components and sediment concentration are obtained using acoustic and optical backscatter instruments. The paths of the axis of the experimental buoyant plumes in cross-flow have been compared to integral laws by Fisher et al. (1979), showing relatively good agreement for plumes not influenced by the dredger’s hull. Plumes with low relative density difference and high crossflow to outflow velocity ratio deviate from the integral laws due to additional mixing induced by the hull boundary layer and wake

Large-Eddy Simulations of a Sediment-Laden Buoyant Jet Resulting from Dredgers Using Overflow

Interaction between Offshore Utilisation and the Environmen

Lowering the apoptotic threshold in colorectal cancer cells by targeting mitochondria

Background: Colorectal cancer is the third most-common cancer and the second most-common cause of cancer related death in UK. Although chemotherapy plays significant role in the treatment of colorectal cancer, morbidity and mortality due to drug resistance and cancer metastasis are yet to be eliminated. Recently, doxycycline has been reported to have cytotoxic and anti-proliferating properties in various cancer cells. In this study, whether doxycycline was apoptosis threshold lowering agent in colorectal cancer cells by targeting mitochondria was answered.Results: This study showed dose-dependent cytotoxic effects of cisplatin, oxaliplatin and doxycycline in HT29 colorectal cancer cells. Doxycycline showed inhibition of cytochrome-c-oxidase activity in these cells over a time period. The pre-treatment of doxycycline reported statistically significant increased cytotoxicity of cisplatin and oxaliplatin compared to cisplatin and oxaliplatin alone. The caspase studies revealed significantly less expression and activity of caspase 3 in HT29 cells pre-treated with doxycycline compared to the cells treated with cisplatin and oxaliplatin alone.Conclusions: It was concluded that doxycycline lowered the apoptotic threshold in HT 29 cells by targeting mitochondria. This also raised possible caspase-independent mechanisms of apoptosis in HT29 cells when pre-treated with doxycycline however this needs further research work

Security and Privacy Implications of Pervasive Memory Augmentation

Pervasive computing is beginning to offer the potential to rethink and redefine how technology can support human memory augmentation. For example, the emergence of widespread pervasive sensing, personal recording technologies, and systems for the quantified self are creating an environment in which it's possible to capture fine-grained traces of many aspects of human activity. Contemporary psychology theories suggest that these traces can then be used to manipulate our ability to recall - to both reinforce and attenuate human memories. Here, the authors consider the privacy and security implications of using pervasive computing to augment human memory. They describe a number of scenarios, outline the key architectural building blocks, and identify entirely new types of security and privacy threats-namely, those related to data security (experience provenance), data management (establishing new paradigms for digital memory ownership), data integrity (memory attenuation and recall-induced forgetting), and bystander privacy. Together, these threats present compelling research challenges for the pervasive computing research community. This article is part of a special issue on privacy and security

Advanced backcross QTL mapping of resistance to Fusarium head blight and plant morphological traits in a Triticum macha × T. aestivum population

While many reports on genetic analysis of Fusarium head blight (FHB) resistance in bread wheat have been published during the past decade, only limited information is available on FHB resistance derived from wheat relatives. In this contribution, we report on the genetic analysis of FHB resistance derived from Triticum macha (Georgian spelt wheat). As the origin of T. macha is in the Caucasian region, it is supposed that its FHB resistance differs from other well-investigated resistance sources. To introduce valuable alleles from the landrace T. macha into a modern genetic background, we adopted an advanced backcross QTL mapping scheme. A backcross-derived recombinant-inbred line population of 321 BC2F3 lines was developed from a cross of T. macha with the Austrian winter wheat cultivar Furore. The population was evaluated for Fusarium resistance in seven field experiments during four seasons using artificial inoculations. A total of 300 lines of the population were genetically fingerprinted using SSR and AFLP markers. The resulting linkage map covered 33 linkage groups with 560 markers. Five novel FHB-resistance QTL, all descending from T. macha, were found on four chromosomes (2A, 2B, 5A, 5B). Several QTL for morphological and developmental traits were mapped in the same population, which partly overlapped with FHB-resistance QTL. Only the 2BL FHB-resistance QTL co-located with a plant height QTL. The largest-effect FHB-resistance QTL in this population mapped at the spelt-type locus on chromosome 5A and was associated with the wild-type allele q, but it is unclear whether q has a pleiotropic effect on FHB resistance or is closely linked to a nearby resistance QTL