Congruent and Incongruent Corticospinal Activations at the Level of Multiple Effectors

Motor resonance is defined as the subliminal activation of the motor system while observing actions performed by others. However, resonating with another person's actions is not always an appropriate response: In real life, people do not just imitate but rather respond in a suitable fashion. A growing body of neurophysiologic studies has demonstrated that motor resonance can be overridden by complementary motor responses (such as preparing a precision grip on a small object when seeing an open hand in sign of request). In this study, we investigated the relationship between congruent and incongruent corticospinal activations at the level of multiple effectors. The modulation of MEPs evoked by single-pulse TMS over the motor cortex was assessed in upper and lower limb muscles of participants observing a soccer player performing a penalty kick straight in their direction. Study results revealed a double dissociation: Seeing the soccer player kicking the ball triggered a motor resonance in the observer's lower limb, whereas the upper limb response afforded by the object was overridden. On the other hand, seeing the ball approaching the observers elicited a complementary motor activation in upper limbs while motor resonance in lower limbs disappeared. Control conditions showing lateral kicks, mimicked kicks, and a ball in penalty area were also included to test the motor coding of object affordances. Results point to a modulation of motor responses in different limbs over the course of action and in function of their relevance in different contexts. We contend that ecologically valid paradigms are nowadays needed to shed light on the motor system functioning in complex forms of interaction

The charm of structural neuroimaging in insanity evaluations. guidelines to avoid misinterpretation of the findings

Despite the popularity of structural neuroimaging techniques in twenty-first-century research, its results have had limited translational impact in real-world settings, where inferences need to be made at the individual level. Structural neuroimaging methods are now introduced frequently to aid in assessing defendants for insanity in criminal forensic evaluations, with the aim of providing “convergence” of evidence on the mens rea of the defendant. This approach may provide pivotal support for judges’ decisions. Although neuroimaging aims to reduce uncertainty and controversies in legal settings and to increase the objectivity of criminal rulings, the application of structural neuroimaging in forensic settings is hampered by cognitive biases in the evaluation of evidence that lead to misinterpretation of the imaging results. It is thus increasingly important to have clear guidelines on the correct ways to apply and interpret neuroimaging evidence. In the current paper, we review the literature concerning structural neuroimaging in court settings with the aim of identifying rules for its correct application and interpretation. These rules, which aim to decrease the risk of biases, focus on the importance of (i) descriptive diagnoses, (ii) anatomo-clinical correlation, (iii) brain plasticity and (iv) avoiding logical fallacies, such as reverse inference. In addition, through the analysis of real forensic cases, we describe errors frequently observed due to incorrect interpretations of imaging. Clear guidelines for both the correct circumstances for introducing neuroimaging and its eventual interpretation are defined

Time-scale analysis non-local diffusion systems, applied to disease models

The objective of the present paper is to use the well known Ross-Macdonald models as a prototype, incorporating spatial movements, identifying different times scales and proving a singular perturbation result using a system of local and non-local diffusion. This results can be applied to the prototype model, where the vector has a fast dynamics, local in space, and the host has a slow dynamics, non-local in space

Tools in the orbit space approach to the study of invariant functions: rational parametrization of strata

Functions which are equivariant or invariant under the transformations of a compact linear group $G$ acting in an euclidean space $\real^n$, can profitably be studied as functions defined in the orbit space of the group. The orbit space is the union of a finite set of strata, which are semialgebraic manifolds formed by the $G$-orbits with the same orbit-type. In this paper we provide a simple recipe to obtain rational parametrizations of the strata. Our results can be easily exploited, in many physical contexts where the study of equivariant or invariant functions is important, for instance in the determination of patterns of spontaneous symmetry breaking, in the analysis of phase spaces and structural phase transitions (Landau theory), in equivariant bifurcation theory, in crystal field theory and in most areas where use is made of symmetry adapted functions. A physically significant example of utilization of the recipe is given, related to spontaneous polarization in chiral biaxial liquid crystals, where the advantages with respect to previous heuristic approaches are shown.Comment: Figures generated through texdraw package; revised version appearing in J. Phys. A: Math. Ge

Vietnamellidae (Insecta, Ephemeroptera) of Thailand.

The genus Vietnamella Tshernova, 1972 is investigated in detail for the first time in Thailand. As a consequence, four species are recognized, namely Vietnamella maculosasp. nov., Vietnamella thani Tshernova, 1972, Vietnamella sp. B and Vietnamella sp. C. Herein, larvae and eggs of V. maculosasp. nov. are described and reported from Chiang Rai Province. The larva of Vietnamella sp. B from Tak Province is also described, but not named due to insufficient material, and the imaginal stages and eggs of V. thani Tshernova, 1972 are described and presented for the first time. Our morphological evidence is supported with COI data. The phylogeny showed that four different lineages of the genus Vietnamella occur in Thailand, one of them, viz., Vietnamella sp. C, only known from a couple of COI sequences retrieved from the Barcode of Life Data System (BOLD). Diagnoses for all known Oriental species are also presented

Extended X-ray emission in the IC 2497 - Hanny's Voorwerp system: energy injection in the gas around a fading AGN

We present deep Chandra X-ray observations of the core of IC 2497, the galaxy associated with Hanny's Voorwerp and hosting a fading AGN. We find extended soft X-ray emission from hot gas around the low intrinsic luminosity (unobscured) AGN ($L_{\rm bol} \sim 10^{42}-10^{44}$ erg s$^{-1}$). The temperature structure in the hot gas suggests the presence of a bubble or cavity around the fading AGN (\mbox{E_{\rm bub}} \sim 10^{54} - 10^{55} erg). A possible scenario is that this bubble is inflated by the fading AGN, which after changing accretion state is now in a kinetic mode. Other possibilities are that the bubble has been inflated by the past luminous quasar ($L_{\rm bol} \sim 10^{46}$ erg s$^{-1}$), or that the temperature gradient is an indication of a shock front from a superwind driven by the AGN. We discuss the possible scenarios and the implications for the AGN-host galaxy interaction, as well as an analogy between AGN and X-ray binaries lifecycles. We conclude that the AGN could inject mechanical energy into the host galaxy at the end of its lifecycle, and thus provide a source for mechanical feedback, in a similar way as observed for X-ray binaries.Comment: 9 pages, 5 figures, accepted for publication in MNRA

The Role of MicroRNAs in Influencing Body Growth and Development

Body growth and development are regulated among others by genetic and epigenetic factors. MicroRNAs (miRNAs) are epigenetic regulators of gene expression that act at the post-transcriptional level, thereby exerting a strong influence on regulatory gene networks. Increasing studies suggest the importance of miRNAs in the regulation of the growth plate and growth hormone (GH)-insulin-like growth factor (IGF) axis during the life course in a broad spectrum of animal species, contributing to longitudinal growth. This review summarizes the role of miRNAs in regulating growth in different in vitro and in vivo models acting on GH, GH receptor (GHR), IGFs, and IGF1R genes besides current knowledge in humans, and highlights that this regulatory system is of importance for growth

Design and experimental assessment of a novel damper with high endurance to seismic loads

The study presents the design and the experimental characterization of a new energy dissipation device aimed at providing improved resistance to repeated seismic loads. Differently from conventional steel hysteretic dampers, which dissipate energy by yielding of a mild steel core and are noted to suffer low-cycle fatigue, the new damper provides energy dissipation by the friction that is activated between a moving shaft and a lead core prestressed within a tube. The prestress level is controlled during the assembling process, allowing to adjust the axial strength of the damper. Thanks to the ability of lead to restore its properties by static recrystallization taking place immediately after deformation, repeated cycles of loading do not produce damages that may accrue and eventually lead to failure of the device. Moreover, prestressing of the lead core allows to achieve high specific strength (i.e., high force to volume ratio), thereby providing low dimensions which help to reduce the architectural invasiveness. Prototypes of the damper were subjected to the test procedure established in the European standard EN 15129 for Displacement Dependent Devices, fulfilling the relevant requirements. The damper provides a robust and stable response over repeated cycles, characterized by essentially rectangular hysteresis loops with an equivalent viscous damping ratio ξeff of about 55%. Moreover, it shows low sensitivity of mechanical properties on the loading rate and the ability to withstand multiple cycles of motion at the design earthquake displacement without deterioration of performance, demonstrating maintenance-free operation in presence of repeated ground shakes. Its ability to survive several strong motions without being damaged, and its high damping capability coupled to a compact design and low manufacturing cost, are the distinctive features that make it suitable for social housing