93 research outputs found
Preparation and Heavy Metal Ions Chelating Properties of Multifunctional Polymer-Grafted Silica Hybrid Materials
In this research work, novel hybrid materials based on multifunctional polymers and silica were developed and investigated in view of possible employment as sorbents for removal of heavy metal ions from water in presence of various ions. Organic-inorganic hybrid materials were prepared by covalent bonding of vinyl-terminated polyamidoamine (PAA) onto aminated silica particles. Two series of polyamidoamine-grafted silica, differing in the PAA chemical structure, were synthesized, and their heavy metal ions chelating properties were investigated. Column adsorption procedure for Cu, Zn, and Ni in aqueous solution was successfully established. Moreover, the adsorption behaviour of the materials was evaluated in different ionic strength solutions as well as in distilled and natural water. Organic-inorganic hybrid materials exhibited excellent chelating properties and selectivity for different metal ions. The hybrid columns showed exceptional eluting and regenerating property using diluted hydrochloric acid solution as eluent. In particular, the hybrid materials containing more carboxy groups possessed superior adsorption ability, reusability, and stability. The consecutive adsorption-desorption experiments exhibited that this material could be reused more than 20 cycles without almost any loss of adsorption capability. These new organic-inorganic sorbents appear very promising as an effective solid-phase extraction material for the selective preconcentration or removing of heavy metal ions from the environment
Designing Viscoelastic Gelatin-PEG Macroporous Hybrid Hydrogel with Anisotropic Morphology and Mechanical Properties for Tissue Engineering Application
The mechanical properties of scaffolds play a vital role in regulating key cellular processes
in tissue development and regeneration in the field of tissue engineering. Recently, scaffolding
material design strategies leverage viscoelasticity to guide stem cells toward specific tissue regeneration.
Herein, we designed and developed a viscoelastic Gel-PEG hybrid hydrogel with anisotropic
morphology and mechanical properties using a gelatin and functionalized PEG (as a crosslinker)
under a benign condition for tissue engineering application. The chemical crosslinking/grafting
reaction was mainly involved between epoxide groups of PEG and available functional groups
of gelatin. FTIR spectra revealed the hybrid nature of Gel-PEG hydrogel. The hybrid hydrogel
showed good swelling behavior (water content > 600%), high porosity and pore interconnectivity
suitable for tissue engineering application. Simple unidirectional freezing followed by a freeze-drying
technique allowed the creation of structurally stable 3D anisotropic macroporous architecture that
showed tissue-like elasticity and was capable of withstanding high deformation (50% strain) without
being damaged. The tensile and compressive modulus of Gel-PEG hybrid hydrogel were found to
be 0.863 MPa and 0.330 MPa, respectively, which are within the range of normal human articular
cartilage. In-depth mechanical characterizations showed that the Gel-PEG hybrid hydrogel possessed
natural-tissue-like mechanics such as non-linear and J-shaped stress-strain curves, stress softening
effect, high fatigue resistance and stress relaxation response. A month-long hydrolytic degradation
test revealed that the hydrogel gradually degraded in a homogeneous manner over time but
maintained its structural stability and anisotropic mechanics. Overall, all these interesting features
provide a potential opportunity for Gel-PEG hybrid hydrogel as a scaffold in a wide range of tissue
engineering applications
Bone Regeneration Using Mesenchymal Stromal Cells and Biocompatible Scaffolds: A Concise Review of the Current Clinical Trials
: Bone regenerative medicine is a clinical approach combining live osteoblast progenitors, such as mesenchymal stromal cells (MSCs), with a biocompatible scaffold that can integrate into host bone tissue and restore its structural integrity. Over the last few years, many tissue engineering strategies have been developed and thoroughly investigated; however, limited approaches have been translated to clinical application. Consequently, the development and clinical validation of regenerative approaches remain a centerpiece of investigational efforts towards the clinical translation of advanced bioengineered scaffolds. The aim of this review was to identify the latest clinical trials related to the use of scaffolds with or without MSCs to regenerate bone defects. A revision of the literature was performed in PubMed, Embase, and Clinicaltrials.gov from 2018 up to 2023. Nine clinical trials were analyzed according to the inclusion criteria: six presented in the literature and three reported in Clinicaltrials.gov. Data were extracted covering background trial information. Six of the clinical trials added cells to scaffolds, while three used scaffolds alone. The majority of scaffolds were composed of calcium phosphate ceramic alone, such as β-tricalcium phosphate (TCP) (two clinical trials), biphasic calcium phosphate bioceramic granules (three clinical trials), and anorganic bovine bone (two clinical trials), while bone marrow was the primary source of the MSCs (five clinical trials). The MSC expansion was performed in GMP facilities, using human platelet lysate (PL) as a supplement without osteogenic factors. Only one trial reported minor adverse events. Overall, these findings highlight the importance and efficacy of cell-scaffold constructs in regenerative medicine under different conditions. Despite the encouraging clinical results obtained, further studies are needed to assess their clinical efficacy in treating bone diseases to optimize their application
Dynamic Freedom: Substrate Stress Relaxation Stimulates Cell Responses
An elastic substrate stores cell-induced forces, while a viscoelastic substrate dissipates these forces through matrix reorganization and facilitates cell proliferation and differentiation
Process for preparing zinc dicarboxylate and use thereof as a catalyst in the synthesis of polyalkylene carbonate from co2 by heterogeneous catalysis
The present invention relates to a process for the synthesis of a zinc-based compound having general formula (I): wherein L is selected in the group consisting of: NO3, CH3CO2, (SO4)0.5, halide, and acetyl acetonate (AcAc), 2x = y + z; wherein x is comprised between 1 and 5, y is comprised between 1 and 8, z is comprised between 1 and 2, and n is comprised between 0 and 20. Said zinc-based compound is then used for the synthesis of a zinc dicarboxylate catalyst to be used for the heterogeneous catalytic copolymerization of a polyalkylene carbonate starting from CO2 and an alkyl epoxide, preferably containing at least 3 atoms of carbon, said polyalkylene carbonate being characterised by chemical-physical and mechanical properties which make it advantageous for a variety of different applications
Polyalkylene carbonate obtained from biodegradable co2 and with self-healing properties
The present invention relates to a polyalkylene carbonate, preferably PRC, and the use thereof in packaging, in coating surfaces, in cosmetics, in the biomedical or textile sector or to produce composite materials or moisture absorption devices. Preferably, said polyalkylene carbonate is obtained by reacting CO2 with an alkyl epoxide preferably containing at least 3 atoms of carbon, preferably propylene oxide, in the presence of a zinc dicarboxylate catalyst; said catalyst being obtained by reacting, with a preferably saturated aliphatic dicarboxylic acid, a zinc-based compound comprising a mixture of ZnO and a compound having the general formula (I): Znx(0H)y(L)z-nH2 O (I) wherein L is selected in the group consisting of: NO3, CH3CO2, (SO4)0.5, halide, and acetyl acetonate (AcAc), 2x = y + z; wherein x is comprised between 1 and 5, y is comprised between 1 and 8, z is comprised between 1 and 2, and n is comprised between 0 and 20
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