Pinealectomy Increases and Exogenous Melatonin Decreases Leptin Production in Rat Anterior Pituitary Cells: an Immunohistochemical Study

Summary Melatonin, the main hormone of the pineal gland, informs the body about the environmental light and darkness regimen, which in turn contributes to the photoperiodic adaptation of several physiological functions. Leptin, the hormone secreted mainly by adipocytes and some other tissues including the pituitary, informs the brain about the mass of adipose tissue, which plays an important role in energy homeostasis. Melatonin has been shown to decrease circulating leptin levels. It is currently not known whether melatonin has an effect on leptin synthesis in the pituitary. The aim of this study was to immunohistochemically examine the effects of pinealectomy and administration of melatonin on leptin production in the rat anterior pituitary. The pituitary samples obtained from 18 male Wistar rats including sham-pinealectomized, pinealectomized and melatonin-injected pinealectomized groups were immunohistochemically evaluated. Immunostaining of leptin was moderate (3+) in sham-pinealectomized rats, heavy (5+) in pinealectomized rats and low (1+) in melatonin-treated pinealectomized rats, respectively. The present results indicate that pinealectomy induces leptin secretion in anterior pituitary cells, and this increase of leptin synthesis can be prevented by administration of melatonin. Thus, melatonin seems to have both physiological and pharmacological effects on leptin production in the anterior pituitary of male rats

The Grizzly, February 3, 2005

Students Videoconference with Sri Lanka • Forensics Team Coach-less • Where Have All the Trees Gone? • It\u27s Cold in Here • Learning the Roots and Aspects of Freedom of Expression: Special Topic Course • Contraception and the Y Chromosome: Male Birth Control Options • Influenza: How to Survive the Yearly Epidemic • Where in the World is Your Study Abroad Application? • Opinions: Random Rantings of Racial Relations; Law Should not Justify Artificial Survival • Gymnastics Team Ranked First in Nation • Fourth Time\u27s the Charm • Gaining Ground in the Ranks of the Collegiate Wrestling Worldhttps://digitalcommons.ursinus.edu/grizzlynews/1576/thumbnail.jp

The Grizzly, April 28, 2005

Commencement 2005 • Students Protest Laptop Buyback • Got Talent? • Kaleidoscope Opens • Diversity Week a Success • Ursinus Dancers Preview Work in the Scope • Students Prove Educational Value in Buffy • How to Have a Great Summer • Let the Art Speak for Itself : Preview of the Annual Art Exhibition • Opinions: Most Controversial; Thoughts of a Rising Senior; Turn from Intolerance • Road to the Playoffs in Sight • Lacrosse Team Denied First Conference Win • Intramural Sports Becoming a Popular Alternativehttps://digitalcommons.ursinus.edu/grizzlynews/1585/thumbnail.jp

Characteristics of Different Systems for the Solar Drying of Crops

Solar dryers are used to enable the preservation of agricultural crops, food processing industries for dehydration of fruits and vegetables, fish and meat drying, dairy industries for production of milk powder, seasoning of wood and timber, textile industries for drying of textile materials. The fundamental concepts and contexts of their use to dry crops is discussed in the chapter. It is shown that solar drying is the outcome of complex interactions particular between the intensity and duration of solar energy, the prevailing ambient relative humidity and temperature, the characteristics of the particular crop and its pre-preparation and the design and operation of the solar dryer

Zinc, copper and iron concentrations in cerebral cortex of male rats exposed to formaldehyde inhalation

Retrospective cohort studies and clinical findings have suggested effects of formaldehyde exposure on the central nervous system in anatomists, embalmers and pathologists. On the other hand, harmful effects of formaldehyde inhalation on the nervous system are not well documented. The concentrations of elements such as zinc, copper and iron within the cerebral cortex indicate whether physiological conditions are maintained. In this study, adult male albino Wistar rats were exposed to formaldehyde at different concentrations (0; 6.1; 12.2 mg·m-3) and during different periods of time (subacute-subchronic), and body weights were recorded weekly. Zinc, copper and iron concentrations were measured in the parietal cortex using atomic absorption spectrometry after wet ashing. We conclude that subacute or subchronic exposure to formaldehyde may cause growth retardation and alter zinc, copper and iron levels in the cerebral cortex

Effects of formaldehyde inhalation on zinc, copper and iron concentrations in liver and kidney of male rats

In the present study, adult Wistar albino male rats were exposed to formaldehyde at different periods (subacute and subchronic) and concentrations (5.0 and 10.0 ppm) in order to figure out the changes in the concentration of Zn, Cu and Fe. It was observed that the formaldehyde inhalation caused gradual decline of body weights in the experimental groups when compared with control groups. It was found that subacute (4-week) or subchronic (13-week) exposure to formaldehyde for rats may cause growth retardation. After inhalation procedure, concentration of copper, zinc and iron were determined in liver and kidney tissues of rats using atomic absorption spectrophotometer. In addition, concentrations of Cu, Zn and Fe changed by the effect of formaldehyde in subacute and subchronic groups. © 2010 Springer Science+Business Media, LLC

Changes of zinc, copper, and iron levels in the lung of male rats after subacute (4-week) and subchronic (13-week) exposure to formaldehyde

The medical use of formaldehyde has focused especially on laboratory use. Harmful effects of formaldehyde inhalation, such as nasal squamous cell carcinoma, are quite well documented. However, detailed studies of the mechanisms of the damaging effects of formaldehyde on lung tissue are quite limited. Amounts of such elements as zinc, copper, and iron within lung tissue indicate whether or not they function physiologically. In this study, 36 adult albino Wistar male rats (6 animals per group) were exposed to 0 (Control), 5, and 10 ppm (1 ppm ? 1.2 mg/m3) of formaldehyde gas for subacute (4-week) and subchronic (13-week) periods. Whole-body exposure was continuously carried out for 8 h/day, 5 days/week. Body weights were recorded weekly. Levels of metals mentioned above were measured in lung tissue by atomic absorption spectrometry using wet ashing and were then compared with levels in the control groups. At the end of the study, a gradual decrease in weight gain, a decrease in zinc levels, and an increase in iron levels were observed in both subacute and subchronic groups compared to control groups. Statistically significant increases in tissue Fe levels were seen in the 10 ppm subacute (P < 0.001), 5 ppm subchronic (P < 0.001), and 10 ppm subchronic (P < 0.001) groups. We conclude that subacute or subchronic exposure to cytotoxic concentrations of formaldehyde may cause growth retardation and alter the trace element levels of zinc and iron in the lung tissue. © 2003 Wiley-Liss, Inc

Primary osteosarcoma arising from subcutaneous tissue: 5-year follow-up

PubMed ID: 22726985Extraskeletal osteosarcomas are extremely rare, high-grade neoplasms. Approximately 300 cases have been reported in the literature, with a 5-year survival of around 25%-37%. Extraskeletal osteosarcomas frequently arise from lower-extremity, deep soft tissue planes, including hemorrhagic, necrotic areas. While primary osteosarcomas have been observed in the first two decades of life, osteosarcomas arising from the skeletal system are rarely observed before 40 years of age. We present radiological findings of an osteosarcoma case arising from cruris subcutaneous tissue in a young adult (31 years old) at diagnosis and at the follow-up period during a 5-year monitoring process. Additionally, we reviewed the literature regarding this case. © 2012 Elsevier Inc