Bonesetter choice of Turkish society in musculoskeletal injuries and the affecting factors

Objective: In this study, it was aimed to investigate the demographic features, administration reasons and educational status of the patients who were presented to the bonesetters for orthopedic complaints. Methods: 96 (26 males, 70 females) patients were included in this study, who filled a questionnaire out of 1926 patients went to bonesetters between June and December 2012. All the patients were recorded regarding demographic features, first application places, educational status, administration reasons, and complication rates. Results: 87 patients (90.6%) preferred bonesetters as the first application place. The mean age of the patients was 31±16.1 years. The most common reason was advices of the family members or relatives (40.6%). The educational status was not significant in administration rate, but low educational status has significant correlation with more complication rates. Sixteen patients developed sequels (16.6%). The effect of bonesetters’ treatment was mostly found to be placebo. Conclusion: Bonesetter is a country reality when prevalence was taken in notice. However, the similarity of their results to placebo ones, having no education, having no legal rights, paying no tax make this issue a great problem. The solution of this problem is depended to increase health programs to inform public and to increase government superintension. J Clin Exp Invest 2013; 4 (4): 472-44

Trimetoprime Bağlı Gelişen Tip IV Renal Tübüler Asidoz

Çeşitli maligniteler, primer immün yetmezlik, HIV/AIDS, organ/kemik iliği nakli, kortikosteroid, immünsüpresif ajanlar ve bazı ilaçların kullanımı ba- ğışıklık sisteminin zayıflamasına yol açarak pnömosistis jiroveci pnömonisine zemin hazırlar. Pnömosistis jiroveci pnömonisinde trimetoprim- sülfametoksazol (TMP- SMX) kullanılır. Tedavide kullanılan TMP’e bağlı gelişen Tip IV renal tübüler asidoz (Tip IV RTA) nadirdir. Burada TMP’e bağlı Tip IV renal tübüler asidoz gelişen 71 yaşında bayan hastayı sunuyoruz

Serum Bcl-2 Levels in Patients with β-Thalassemia Minor: A Pilot Study β-Talasemi Minörlü Hastalarda Serum Bcl-2 Düzeyleri: Pilot Çalışma

Abstract: Objective: Anti-apoptotic proteins such as Bcl-2 and Bcl-xL may play a role in the survival of erythroid progenitor cells. Information about these proteins in patients with β-thalassemia minor is limited. We aimed to determine the levels of serum Bcl-2 in patients with β-thalassemia minor. Materials and Methods: Ninety-seven patients (60 females and 37 males with mean age of 29±21 years) with β-thalassemia minor were enrolled in this study. The diagnosis of β-thalassemia minor was based on whole blood counts, family history, and HbA2 levels estimated by high-performance liquid chromatography. The control group comprised 23 healthy adults (17 females and 6 males with mean age of 58±9 years) without anemia. The levels of serum Bcl-2 were measured by enzyme-linked immunosorbent assay. Mann-Whitney U tests were used in statistical evaluation and p<0.05 was accepted as statistically significant. Results: Although there was no statistically significant difference between patients with β-thalassemia minor and the control group for the level of serum Bcl-2 (p>0.05), these levels were higher in β-thalassemia minor patients than controls. Conclusion: There are damaged beta chains in β-thalassemia minor. Therefore, it is expected that premature death of red blood cells may occur due to apoptosis. The mean age of the control group was higher than that of the β-thalassemia minor group; this may be why Bcl-2 levels were higher in the β-thalassemia minor group. It is known that older age constitutes a risk for increased apoptosis. Other proteins (Bad, Bax, etc.) and pathways [CD95 (Fas) ligand] associated with apoptosis should be evaluated in future studies including more patients

Serum Bcl-2 Levels in Patients with β-Thalassemia Minor: A Pilot Study

OBJECTIVE: Anti-apoptotic proteins such as Bcl-2 and Bcl-xL may play a role in the survival of erythroid progenitor cells. Information about these proteins in patients with β-thalassemia minor is limited. We aimed to determine the levels of serum Bcl-2 in patients with β-thalassemia minor. METHODS: Ninety-seven patients (60 females and 37 males with mean age of 29±21 years) with β-thalassemia minor were enrolled in this study. The diagnosis of β-thalassemia minor was based on whole blood counts, family history, and HbA2 levels estimated by high-performance liquid chromatography. The control group compromised 23 healthy adults (17 females and 6 males with mean age of 58±9 years) without anemia. The levels of serum Bcl-2 were measured by enzyme-linked immunosorbent assay. Mann–Whitney U tests were used in statistical evaluation and p< 0.05 was accepted as statistically significant. RESULTS: Although there was no statistically significant difference between patients with β-thalassemia minor and the control group for the level of serum Bcl-2 (p>0.05), these levels were higher in β-thalassemia minor patients than controls. CONCLUSION: There are damaged beta chains in β-thalassemia minor. Therefore, it is expected that premature death of red blood cells may occur due to apoptosis. The mean age of the control group was higher than that of the β-thalassemia minor group; this may be why Bcl-2 levels were higher in the β-thalassemia minor group. It is known that older age constitutes a risk for increased apoptosis. Other proteins (Bad, Bax, etc.) and pathways [CD95 (Fas) ligand] associated with apoptosis should be evaluated in future studies including more patients

Taşsız Akut Kolesistit ve Ciddi Trombositopenili Weil Hastalığı: Olgu Sunumu

Leptospiroz dünyada sık görülen bir zoonozdur. Weil hastalığı, leptospirozun ağır formudur. Weil hastalığında sıklıkla sarılık, böbrek disfonksiyonu ve hemoraji gözlenir. Taşsız akut kolesistit ve ciddi trombositopeninin eşlik ettiği Weil hastalığı nadirdir. Biz burada, 58 yaşında erkek hastada akut taşsız kolesistit ve ciddi trombositopeninin eşlik ettiği Weil hastalığını sunuyoruz

Poli kistik over sendromunda ses özellikleri

P125POLİKİSTİK OVER SENDROMUNDA SES ÖZELLİKLERİKADRİyE AyDIN1, SEVTAP AKBULUT2, MEHMET GÖKHAN DEMİR2, şEVİN DEMİR3, AyşENUR öZDERyA1, şULE TEMİZKAN1, MEHMET SARGIN31. KArTAlDrlÜTfiKIrDAreğiTimveArAŞTIrmAhASTAneSi enDoKrinoloji ve meTAbolizmA hASTAlIKlArI ÜniTeSi, iSTAnbUl2. KArTAl Dr lÜTfi KIrDAr eğiTim ve ArAŞTIrmA hASTAneSi KUlAK bUrUn boğAz Kliniği, iSTAnbUl3. KArTAlDrlÜTfiKIrDAreğiTimveArAŞTIrmAhASTAneSi Aile heKimliği Kliniği, iSTAnbUlAmaç:Polikistik over sendromu (PKOS) doğurganlık ça- ğındaki kadınlarda sık görülen, yüksek androjen düzeyi, oligoovulasyon/ anovulasyon ve overlerde polikistik görü- nümle ile karakterize bir sendromdur. PKOS’lu hastalarda ses özelliklerinin değiştiği varsayılmaktadır. Ancak PKOS olan kadınlarda ses özelliklerinin subjektif ve objektif de- ğişimi ayrıntılı olarak incelenmemiştir.Materyal-Metod:Çalışmaya 30 PKOS olan hasta ile, ben- zer yaş ve vücut kitle indeksine (VKİ) sahip 22 sağlık kadın kontrol grubu olarak alındı. Her iki grupta demografik ve- riler, antropometrik ölçümler, lipid parametreleri, glukoz metabolizması belirteçleri, foliküler fazda serum andro- jenleri değerlendirildi. Ses özellikleri ‘Dr Speech’ progra- mı ile elektronik ortamda incelendi. Katılımcıların vokal kordları laringostrotoboskopi ile muayene edildi ve ses handikap indeksi (SHİ) sorgulandı.Bulgular:Hasta ve kontrol grubu arasında total testoste- ron, serbest androjen indeksi, DHEAS açısından anlamlı fark var iken (sırasıyla p&lt;0.001, p=0.002, p=0.040), ana ses parametreleri açısından(fundamental frekans, shimmer ve jitter) istatistiksel fark saptanmadı. Ses parametreleri- nin çalışma parametreleri ile hasta ve kontrol grubundaki korelasyonunda, androjen düzeyleri ile fundamental fre- kans, shimmer ve jitter arasında bağıntı saptanmadı. An- cak hasta ve kontrol grubu arasında SHİ sonuçları anlamlı olarak farklı bulundu (p=0.015).Sonuç:PKOS olan hastalarda androjen düzeylerinin ses parametrelerine etkisi gösterilememiştir. Ancak hastalar ve kontrollerin SHİ’lerinin farklı olması, PKOS’da subjektif ses yakınmalarının arttığını göstermektedir

Familial Mediterranean fever: perspective on female fertility and disease course in pregnancy from a multicenter nationwide network.

The aim of this study was to analyze the pregnancy process, especially the Familial Mediterranean fever (FMF) disease course and attack types during pregnancy, and to examine the relationship between disease-related factors and female infertility in FMF patients. The study, which was planned in a multicenter national network, included 643 female patients. 435 female patients who had regular sexual intercourse were questioned in terms of infertility. Pregnancy and delivery history, FMF disease severity and course during pregnancy were evaluated. The relationship between demographic and clinical findings, disease severity, genetic analysis results and infertility was investigated. 401 patients had at least 1 pregnancy and 34 patients were diagnosed with infertility. 154 patients had an attack during pregnancy. 61.6% of them reported that attacks during pregnancy were similar to those when they were not pregnant. The most common attack symptoms were fever, fatigue and abdominal pain-peritonitis (96%, 87%, and 83%, respectively) in the pregnancy period. The disease-onset age, disease activity score, gene mutation analyses, and regular colchicine use (> 90%) were similar between the fertile and infertile groups, while the frequency of previous appendectomy and alcohol consumption rates were higher in individuals with infertility. Our results indicated no significant change in the frequency and severity of attacks during pregnancy. The low rate of infertility (7.8%) in our patients was noted. It has been suggested that the risk of FMF-related infertility may not be as high as thought in patients who are followed up regularly and received colchicine