60 research outputs found
Prospective subjective evaluation of swallowing function and dietary pattern in head and neck cancers treated with concomitant chemo-radiation
Aim : Prospective subjective evaluation of swallowing function and
dietary pattern in locally advanced head and neck cancer patients
treated with concomitant chemo-radiotherapy (CRT). Materials and
Methods : Prospective evaluation of swallowing function with
performance status scale for head and neck cancer patients (PSSHN) at
pre-CRT, CRT completion and at subsequent follow-ups in adult with
loco-regionally advanced head and neck squamous cell carcinoma (HNSCC)
patients. Results : In 47 patients (40 male, seven females; mean age
53; 72% smoker 53%, oropharyngeal cancer), the mean total PSSHN score
at pre-CRT was 258.5 and decreased to 225.2 and 219.2 at two and six
months respectively. Understandability of speech, normalcy in diet and
eating in public at pre-CRT and six months were 91.5 and 84.4; 80.4 and
63.1; 87.3 and 76.6 respectively. In univariate analysis, pre-CRT PSSHN
scores were significantly lesser in patients with severe pre-CRT
dysphagia (P = 0.001), hypopharyngeal cancer (P = 0.244) and advanced
T-stage (T3/4) disease (P = 0.144). At CRT completion, there was
significant reduction of PSSHN scores in patients with severe pre-CRT
dysphagia (P = 0.008), post-CRT weight loss (>10%) and disease
progression (P = 0.039). At two months and six months, 17 (57%) and 11
(73.5%) patients respectively showed change in dietary habit. Mean
increase in meal time was 13% and 21% at two and six-month follow-up.
Conclusions : HNSCC patients show deterioration in swallowing function
after CRT with normalcy of diet in maximum and eating in public least
affected. Pre-CRT severity of dysphagia, weight loss> 10% and
disease progression have significant correlation with higher swallowing
function deterioration after CRT
Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma : AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines
Purpose: Few studies have reported large inter-observer variations in target volume selection and delineation in patients treated with radiotherapy for head and neck squamous cell carcinoma. Consensus guidelines have been published for the neck nodes (see Gregoire et al., 2003, 2014), but such recommendations are lacking for primary tumour delineation. For the latter, two main schools of thoughts are prevailing, one based on geometric expansion of the Gross Tumour Volume (GTV) as promoted by DAHANCA, and the other one based on anatomical expansion of the GTV using compartmentalization of head and neck anatomy. Method: For each anatomic location within the larynx, hypopharynx, oropharynx and oral cavity, and for each T-stage, the DAHANCA proposal has been comprehensively reviewed and edited to include anatomic knowledge into the geometric Clinical Target Volume (CTV) delineation concept. A first proposal was put forward by the leading authors of this publication (VG and CG) and discussed with opinion leaders in head and neck radiation oncology from Europe, Asia, Australia/New Zealand, North America and South America to reach a worldwide consensus. Results: This consensus proposes two CTVs for the primary tumour, the so called CTV-P1 and CVT-P2, corresponding to a high and lower tumour burden, and which should be associated with a high and a lower dose prescription, respectively. Conclusion: Implementation of these guidelines in the daily practice of radiation oncology should contribute to reduce treatment variations from clinicians to clinicians, facilitate the conduct of multi institutional clinical trials, and contribute to improved care of patients with head and neck carcinoma. (C) 2017 Elsevier B.V. All rights reserved.Peer reviewe
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