Land Grant Application- Jordan, Soloman (Cape Elizabeth)

Land grant application submitted to the Maine Land Office on behalf of Soloman Jordan for service in the Revolutionary War, by their widow Sarah.https://digitalmaine.com/revolutionary_war_me_land_office/1507/thumbnail.jp

The synthesis of GdB-texaphyrins as novel multipurpose cancer drugs

3rd Place, Category of "Health Sciences- Laboratory/Cellular," Denman Undergraduate Research Forum, May 2009Summer Research Fellowship, College of Pharmacy, Summer 2007Undergraduate Research Scholarship, College of Pharmacy, Fall 2006-Spring 2007Texaphyrins are a synthetic class of porphyrin analogues that contain a metal atom complexed at their centers. This class of compounds selectively accumulates in cancer cells, thus creating a promising opportunity for medicinal chemists to synthesize novel anti-cancer agents. Texaphyrins may become especially valuable as anti-cancer agents by synthetically including atoms such as gadolinium and boron into their structures. The presence of either of these elements allows the compounds to be used in Neutron Capture Therapy (NCT), a non-invasive experimental treatment procedure for cancer. While texaphyrins are promising novel agents for use in oncology, better synthetic methods for developing and optimizing these compounds are still needed. The purpose of this study is to find effective synthetic methods for the development of a texaphyrin that could be used in cancer therapy and diagnosis. Two such gadolinium- and boron-containing texaphyrins (GdB-texaphyrins) have already been successfully synthesized in our laboratories and are currently undergoing pre-clinical trials. This project has accomplished the synthesis of the direct pre-cursor to a specific GdB-texaphyrin (pictured on this page), and the compound’s complete synthesis will continue to be pursued in our laboratories. This study has therefore provided valuable data about the pursued synthetic pathway to help researchers continue to advance the synthesis of this novel class of anti-cancer agents.This work was financially supported by The Ohio State University College of Pharmacy.No embarg

Long-Term Outcomes of Low-Achieving Third Grade Readers

Research shows that students who demonstrate low reading achievement in 3rd grade have trouble catching back up to grade level and being successful in school, compared to their peers who demonstrate early proficiency (Fiester 2010; Hernandez 2011; Juel 1988). This report seeks to investigate what happens to Arkansas public school students who demonstrate low achievement in reading in 3rd grade. Reading scores from three cohorts of students are followed from 3rd grade until high school, beginning with data from the 2008-09 school year and continuing through 2016-17. We examine the demographic characteristics of the low-achieving group, assess the extent to which these low-performers catch up by high school, and we highlight the subgroups of students who make the most progress in catching up to their higher achieving peers. This report is structured around two main research questions

Peer crowd-based targeting in E-cigarette advertisements: a qualitative study to inform counter-marketing.

BACKGROUND:Cigarette lifestyle marketing with psychographic targeting has been well documented, but few studies address non-cigarette tobacco products. This study examined how young adults respond to e-cigarette advertisements featuring diverse peer crowds - peer groups with shared identities and lifestyles - to inform tobacco counter-marketing design. METHODS:Fifty-nine young adult tobacco users in California participated in interviews and viewed four to five e-cigarette advertisements that featured characters from various peer crowd groups. For each participant, half of the advertisements they viewed showed characters from the same peer crowd as their own, and the other half of the advertisements featured characters from a different peer crowd. Advertisements were presented in random order. Questions probed what types of cues are noticed in the advertisements, and whether and how much participants liked or disliked the advertisements. RESULTS:Results suggest that participants liked and provided richer descriptions of characters and social situations in the advertisements featuring their own peer crowd more than the advertisements featuring a different peer crowd. Mismatching age or device type was also noted: participants reported advertisements showing older adults were not intended for them. Participants who used larger vaporizers tended to dislike cigalike advertisements even if they featured a matching peer crowd. CONCLUSION:Peer crowd and lifestyle cues, age and device type are all salient features of e-cigarette advertising for young adults. Similarly, educational campaigns about e-cigarettes should employ peer crowd-based targeting to engage young adults, though messages should be carefully tested to ensure authentic and realistic portrayals

A Computer Simulation Model of the Service Component of a Fast Food Operation: Development, Validation, and Use

A management tool is needed in the food service industry, especially in the area of fast food service, to generate data on which to base the decision to add menu items which could better meet the nutritional needs of the clientele while maintaining an acceptable margin of profit and meeting service needs of the clientele. A computer simulation model of the service component of a fast food service operation was developed and validated to analyze the influence of an additional menu item on speed of service to the customer and margin of profit realized by management. Data were collected for eight consecutive days in a fast food service operation during peak serving periods. Stopwatch measurements were made of arrival and service times. The composition of the order, number of people in an arrival, and whether the order was to be taken out or eaten in the facility, also, were recorded. The data were analyzed to determine the parameters to be utilized in the simulation model. General Purpose Simulation System/360 (GPSS) was used to model the system. The composition of the order was simulated according to the independent cumulative distributions of the observed frequency of items in each of four established food categories. The number of people in the arrival and whether the order was to be taken out or eaten in were simulated according to the cumulative distributions of the frequencies observed. The mean inter-arrival time for each day was used in the model along with the distribution of the inter-arrival times, all of which were exponential. The service times were divided into three elements. The observed distribution of element one service times, the time required for placing and paying for an order, was used in the simulation model. Element two, the waiting time of the customer after placement of an order and before receipt of food, occurred only when more than one order was taken by the service personnel before the first order was filled. Element three service times included the time required for the employee to fill the order and give to the customer. Element three service times and the corresponding frequency of items ordered within each food category were used to determine through regression analysis the partial regression coefficients by day of each category of food. The regression equation was used in the model to obtain the simulated element three values. The distributions and/or the mean values of the simulated data compared favorably with those of the observed data. Simulations of the system with an expanded menu were done on Friday and Monday to determine the effect of an additional menu item on speed of service to the customer and margin of profit realized by the management. Friday evening, with larger orders and longer service and waiting times of the customer, was more sensitive to the addition of a menu item. The addition of fruit to the menu in the simulation model did not negatively alter the various aspects of the queue on Monday. The conclusion was made that the addition of fruit to the menu during the week should be considered by management. Further study of the system on week end days, especially Friday evenings, was recommended to better assess the addition of fruit during that time. Further research was recommended, also, to identify and quantify other components of the fast food service operation that affect waiting time of the customer and margin of profit realized by management through the collection of refined data over a longer period of time

Long-Term Outcomes of Low-Achieving Third Grade Readers

Research shows that students who demonstrate low reading achievement in 3rd grade have trouble catching back up to grade level and being successful in school, compared to their peers who demonstrate early proficiency (Fiester 2010; Hernandez 2011; Juel 1988). This report seeks to investigate what happens to Arkansas public school students who demonstrate low achievement in reading in 3rd grade. Reading scores from three cohorts of students are followed from 3rd grade until high school, beginning with data from the 2008-09 school year and continuing through 2016-17