Dark sector searches at neutrino experiments

Despite considerable progress in the understanding of fundamental particles and interactions and the striking predictive power of the Standard Model in collider experiments, some key questions in the understanding of Nature still remain unanswered. What is the origin of neutrino masses? What is dark matter made of? Why is there an imbalance between baryons and anti-baryons in the Universe? These questions call for new physics beyond the Standard Model. For decades, the majority of the experimental effort has been directed to the search for new particles with sizeable couplings to the Standard Model and masses at the TeV scale. However, recent theoretical and experimental developments have brought new attention to the dark sectors, i.e. extensions of the Standard Model at scales below the electroweak scale and which are weakly coupled to the visible sector. In some of these rich dark sector models, it is possible to have dark photons decaying semi-visibly, meaning that the final state contains both visible and invisible particles, making it possible to circumvent current experimental constraints on the masses of the dark photons and mixing with the SM photon. This project will focus on models containing multiple dark fermions, where the lighter of these can be made stable through some additional symmetry that forbids the mixing with active neutrinos, making it a viable dark matter candidate. This model can leave visible signatures in ProtoDUNE detectors, located at CERN. Protons extracted from the CERN Super Proton Synchrotron (SPS), with energies up to 400 GeV, can generate a flux of BSM particles that can reach the ProtoDUNE detectors. These are liquid Argon Time Projection Chambers (LArTPCs) constructed to test and consolidate the technologies of the DUNE Far Detector. Thanks to its large volume and the high density of liquid argon, stable particles coming into the detector can interact, leading to an excess of electron recoil

Effect on the energy market of the potential switching to heat pumps for space heating

The main subject of this work is to understand what could happen in the Italian electricity market if a given share of building heating demand had switched from gas to electricity heating devices. The objective is to define the optimal share to switch in terms of minimization of environmental (CO2) emissions. The effects of such switching on the national energy system are analyzed from the financial point of view, depending also on the heating habits of final users. An hourly simulation of the electricity market has been performed by means of a bid stack model (BIDSM) developed at University of Genoa, calculating market prices, power plant generation typology, fuel consumption and global CO2 emissions. All the data are averaged on a national basis and results are reported for two different time schedule of heating requirements of the final users. In each case, the total energy consumption is fixed, and local "degree days" and location energy needs are considered. It seems that the use of heat pumps for building heating is a real option and that the user habits has a little impact on optimal share of switching from gas to heat pumps, at least concerning CO2 emission minimization

Multimodal treatment for local recurrent malignant gliomas: resurgery and/or reirradiation followed by chemotherapy

The therapeutic management of recurrent malignant gliomas (MGs) is not determined. Therefore, the efficacy of a multimodal approach and a combination systemic therapy was investigated. A retrospective analysis of 26 MGs patients at first relapse treated with multimodal therapy (chemotherapy plus surgery and/or reirradiation) or chemotherapy alone was performed. Second-line chemotherapy consisted of fotemustine (FTM) in combination with bevacizumab (BEV) (cFTM/BEV) or followed by third-line BEV (sFTM/BEV). Subgroup analyses were performed. Multimodal therapy provided a higher overall response rate (ORR) (73 vs. 47%), disease control rate (DCR) (82 vs. 67%), median progression-free survival (mPFS) (11 vs. 7 months; P=0.08) and median overall survival (mOS) (13 vs. 8 months; P=0.04) compared with chemotherapy. Concomitant FTM/BEV resulted in higher ORR (84 vs. 36%), DCR (92 vs. 57%), mPFS (10 vs. 5 months; P=0.22) and mOS (11 vs. 5.2 months; P=0.15) compared with sFTM/BEV. Methylated patients did not experience additional survival benefits with multimodality treatment but had higher mPFS (10 vs 7.1 months; P=0.33) and mOS (11 vs. 8 months; P=0.33) with cFTM/BEV. Unmethylated patients experienced the greatest survival benefit with the multimodal approach (mPFS: 10 vs. 5 months; mOS 11 vs 6 months; both P=0.02) and cFTM/BEV (mPFS: 5 vs. 2 months; mOS 6 vs. 3.2 months; both P=0.01). In conclusion, in recurrent MGs, multimodal therapy and cFTM/BEV provide survival and response benefits. Methylated patients benefit from a cFTM/BEV but not from a multimodal approach. Notably, unmethylated patients had the highest survival benefit with the two strategies

What Clinicians Need to Know about Respiratory Syncytial Virus Infection in Older Adults

Funding Information: This study was supported by EU funding within the MUR PNRR Extended Partnership initiative on Emerging Infectious Diseases (Project no. PE00000007, INF-ACT). Publisher Copyright: © 2024 by the authors.Respiratory syncytial virus (RSV) is increasingly recognized as being implicated in acute illness in older adults, with a significant weight in hospitalizations for respiratory illness and death. By means of a best-evidence review, this paper aims to investigate whether RSV can be considered a forgotten pathogen in older patients, looking at trends in the literature volume and exploring possible epidemiological and clinical features underlying the focus given to it. We then present an assessment of its disease burden and present and future strategies for its reduction, particularly in light of the recent availability of new vaccines.publishersversionpublishe

3D scaffolds to model the hematopoietic stem cell niche: applications and perspectives

Hematopoietic stem cells (HSC) are responsible for the production of blood and immune cells during life. HSC fate decisions are dependent on signals from specialized microenvironments in the bone marrow, termed niches. The HSC niche is a tridimensional environment that comprises cellular, chemical, and physical elements. Introductorily, we will revise the current knowledge of some relevant elements of the niche. Despite the importance of the niche in HSC function, most experimental approaches to study human HSCs use bidimensional models. Probably, this contributes to the failure in translating many in vitro findings into a clinical setting. Recreating the complexity of the bone marrow microenvironment in vitro would provide a powerful tool to achieve in vitro production of HSCs for transplantation, develop more effective therapies for hematologic malignancies and provide deeper insight into the HSC niche. We previously demonstrated that an optimized decellularization method can preserve with striking detail the ECM architecture of the bone marrow niche and support HSC culture. We will discuss the potential of this decellularized scaffold as HSC niche model. Besides decellularized scaffolds, several other methods have been reported to mimic some characteristics of the HSC niche. In this review, we will examine these models and their applications, advantages, and limitations143FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP2013/17227-

Learning from the past, intervening in the present: the role of conservation science in the challenging restoration of the wall painting Marriage at Cana by Luca Longhi (Ravenna, Italy)

The paper discusses the case study of the Marriage at Cana, a sixteenth century wall painting located in Ravenna and executed by Luca Longhi. A multi-analytical approach based upon OM, SEM–EDS, μ-Raman, μ-FTIR and biological analyses was selected to investigate the painting technique and the state of preservation of the artwork, compromised by a severe alteration. Data demonstrated that the artwork was executed with a dry painting technique: a siccative oil was used as binder, while indigo, lead white, carbon black, ochres, vermilion and red lead were identifed as pigments. Biological analyses clearly allowed identifying Eurotium halophilicum as the fungus responsible for the white patina compromising the painted surface and, according to this result, Biotin T was selected as the most efective biocide to stop the biological attack. The precarious conditions in which the painting was, attributable to previously performed interventions and to the conservation environment, laid the groundwork for a challenging restoration conducted in 2016. Scientifc analyses better clarifed the kind of materials employed in the execution on the artwork, as well as how the previous restoration was carried out; furthermore, analytical data methodologically supported phases of the intervention like cleaning, flling of the lacunae and pictorial retouching, as products were selected on the basis of their afnity to original materials and painting technique. This study will hopefully encourage refections on how a synergic dialogue between conservation science and restoration can represent an important reference point for interventions to be conducted with scientifc criteria and suitable methodology, in the light of the shared vision and common goal of transferring patrimony to future generation