Mapping the feasibility of lignocellulosic biorefinery routes: the relevance of system modelling in life cycle assessment

The defossilization of the chemical industry, together with negative emission technologies like carbon capture and storage and carbon capture and utilization have been defined as essential contributors to curb the climate crisis. To reach climate goals, it will also be necessary to support the sustainable development of biorefining pathways. The objective of this thesis is to determine the environmental weaknesses and strengths of second generation biorefineries. The analysis of different renewable carbon opportunities to reach climate neutrality goals and objectives beyond decarbonization was achieved though the life cycle assessment methodology. Studying different modelling systems allowed to support the consistent development of recommendations and best practices in regulations and standards of biorefineries

Development and validation of a high-throughput 3D cytotoxicity assay to predict CAR T cell efficacy in solid tumors

https://openworks.mdanderson.org/sumexp21/1155/thumbnail.jp

What is the role of tacrolimus and pimecrolimus in atopic dermatitis?

When the standard therapies -- mild topical corticosteroids and moisturizers -- fail in the treatment of atopic dermatitis, patients are left with few proven remedies. The recently introduced topical immunosuppressive treatment --pimecrolimus and tacrolimus -- offer an alternative to topical corticosteroids. Tacrolimus 0.1% (Protopic) appears to be both safe and effective in treating eczema in adults and children (strength of recommendation [SOR]: A). In multiple studies, it has been as effective as potent topical corticosteroids and more effective than mild topical corticosteroids (SOR: A). Pimecrolimus (Elidel) is more effective than placebo but less effective than potent topical corticosteroids (SOR: A). At this time, no data compare pimecrolimus with mild corticosteroids

Attitudes of medical students and trainees about a career in Cardiothoracic surgery

Introduction: Cardiothoracic (CT) surgery is a dynamic and demanding speciality, which is popular amongst medical students thus, posing as a favourable career choice for many. However, a significant proportion of medical students prefer to choose other specialities instead, for various reasons