Orthodontics and obstructive sleep apnea in children

Children who suffer from respiratory problems and obstructive sleep apnea (OSA) commonly exhibit disturbances of craniofacial morphology. A significant number have nasal obstruction associated with a narrow maxilla; maxillary constriction may increase nasal resistance and alter the tongue posture, leading to narrowing of the retroglossal airway and OSA. Sixty children with a case history of oral breathing, snoring, and night time apneas were studied. An orthognathodontic investigation was performed using radiographs that included not only the usual examinations (posteroanterior cephalographs and intraoral radiographs) but also computed tomographic scans. This article discusses the materials and methods and the results of this study

Formal verification and co-simulation in the design of a synchronous motor control algorithm

Mechatronic systems are a class of cyber-physical systems, whose increasing complexity makes their validation and verification more and more difficult, while their requirements become more challenging. This paper introduces a development method based on model-based design, co-simulation and formal verification. The objective of this paper is to show the applicability of the method in an industrial setting. An application case study comes from the field of precision servo-motors, where formal verification has been used to find acceptable intervals of values for design parameters of the motor controller, which have been further explored using co-simulation to find optimal values. The reported results show that the method has been applied successfully to the case study, augmenting the current model-driven development processes by formal verification of stability, formal identification of acceptable parameter ranges, and automatic design-space exploration

Search for radio halos in starburst galaxies

Starburst galaxies are undergoing intense episodes of star formation. In these galaxies, gas is ejected into the surrounding environment through winds created by the effect of hot stars and supernova explosions. When interacting with the intergalactic medium, these winds can produce strong shocks capable of accelerating cosmic rays. The radiation from these cosmic rays mainly occurs in radio and gamma rays. The radio halo can be characterized using the scale height. We searched for the presence of radio halos in a sample of edge-on starburst galaxies gathered from the MeerKAT 1.28 GHz Atlas of Southern Sources in the IRAS Revised Bright Galaxy Sample. We selected a sample of 25 edge-on galaxies from the original sample and modeled their disk and halo contributions. We have detected and characterized 11 radio halos, seven of which are reported here for the first time. We found that the halo scale heights increase linearly with the radio diameters and this relation does not depend on the star formation rate. All galaxies in our sample follow the radio-infrared relation with a q parameter value of $2.5\pm0.1$. The dependence of the halo luminosity on the star formation rate and the infrared luminosity supports the hypothesis that the radio halos are the result of synchrotron radiation produced by relativistic electrons and points toward the fact that the star formation activity plays a crucial role in halo creation. The average scale height of 1 kpc implies a dynamical range of 4 Myr, several orders of magnitude greater than the synchrotron losses for electrons of 10 TeV. This suggests that some process must exist to reaccelerate cosmic rays in the halo if gamma-ray emission of a leptonic origin is detected from the halo. According to the relation between the radio and gamma-ray luminosities, we found that NGC 4666 is a potential gamma-ray source for future observations.Comment: 21 pages, 5 tables, 8 figures. Accepted for publication in Astronomy & Astrophysic

Investigation of the double-lobed sources of the Cygnus constellation core

We present a collection of double-lobed sources towards a area of the Cygnus region at the northern sky, observed at 325 and 610 MHz with the Giant Metrewave Radio Telescope. The 10 resolution achieved at 325 MHz is 5.5 times better than previous studies, while at 610 MHz, these are the first results ever of such a large area, mapped with 6 angular resolution. After a thorough visual inspection of the images at the two bands, we found 43 double-lobed source candidates, proposed as such due to the presence of 2 bright peaks, within a few arcminutes apart, joined by a bridge or a central nucleus. All but two are presented here as a double-lobed candidates for the first time. Thirty nine of the candidates were covered at both bands, and we provide the spectral index information for them. We have searched for positional coincidences between the detected sources/components and other objects from the literature, along the electromagnetic spectrum. Twenty-three candidates possess radio counterpart(s), 12 present infrared counterparts, and 1 showed an overlapping X-ray source. We analysed each candidate considering morphology, counterparts, and spectral indices. Out of the 43 candidates, 37 show characteristics compatible with an extragalactic nature, 2 of probably Galactic origin, 3 remain as dubious cases, though with feature(s) compatible with an extragalactic nature, and the remaining one, evidence of physically unrelated components. The median spectral index of the 40 putative extragalactic sources is . Their celestial surface density at 610 MHz resulted in , across a region lying at the Galactic plane.Fil: Saponara, Juliana. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomía; ArgentinaFil: Benaglia, Paula. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomía; ArgentinaFil: Andruchow, Ileana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Ishwara Chandra, C. H.. National Centre For Radio Astrophysics; IndiaFil: Intema, H. T.. University of Western Australia; Australi

Optimized energy and air quality management of shared smart buildings in the covid-19 scenario

Worldwide increasing awareness of energy sustainability issues has been the main driver in developing the concepts of (Nearly) Zero Energy Buildings, where the reduced energy consumptions are (nearly) fully covered by power locally generated by renewable sources. At the same time, recent advances in Internet of Things technologies are among the main enablers of Smart Homes and Buildings. The transition of conventional buildings into active environments that process, elaborate and react to online measured environmental quantities is being accelerated by the aspects related to COVID-19, most notably in terms of air exchange and the monitoring of the density of occupants. In this paper, we address the problem of maximizing the energy efficiency and comfort perceived by occupants, defined in terms of thermal comfort, visual comfort and air quality. The case study of the University of Pisa is considered as a practical example to show preliminary results of the aggregation of environmental data

Investigation of the WR 11 field at decimeter wavelengths

The massive binary system WR 11 (γ2-Velorum) has recently been proposed as the counterpart of a Fermi source. If this association is correct, this system would be the second colliding wind binary detected in GeV γ-rays. However, the reported flux measurements from 1.4 to 8.64 GHz fail to establish the presence of nonthermal (synchrotron) emission from this source. Moreover, WR 11 is not the only radio source within the Fermi detection box. Other possible counterparts have been identified in archival data, some of which present strong nonthermal radio emission. We conducted arcsec-resolution observations toward WR 11 at very low frequencies (150-1400 MHz) where the nonthermal emission - if existent and not absorbed - is expected to dominate. We present a catalog of more than 400 radio emitters, among which a significant portion are detected at more than one frequency, including limited spectral index information. Twenty-one of these radio emitters are located within the Fermi significant emission. A search for counterparts for this last group pointed at MOST 0808-471; this source is 2´ away from WR 11 and is a promising candidate for high-energy emission, having a resolved structure along 325-1390 MHz. For this source, we reprocessed archive interferometric data up to 22.3 GHz and obtained a nonthermal radio spectral index of - 0.97 ± 0.09. However, multiwavelength observations of this source are required to establish its nature and to assess whether it can produce (part of) the observed γ-rays. WR 11 spectrum follows a spectral index of 0.74 ± 0.03 from 150 to 230 GHz, consistent with thermal emission. We interpret that any putative synchrotron radiation from the colliding-wind region of this relatively short-period system is absorbed in the photospheres of the individual components. Notwithstanding, the new radio data allowed us to derive a mass-loss rate of 2.5 × 10-5 M☉ yr-1, which, according to the latest models for γ-ray emission in WR 11, would suffice to provide the required kinetic power to feed nonthermal radiation processes.Full Table 4 is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/625/A99The radio data presented in this work were obtained with the Giant Metrewave Radio Telescope (GMRT). The GMRT is operated by the National Centre for Radio Astrophysics of the Tata Institute of Fundamental Research.Fil: Benaglia, Paula. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomía; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Observatorio Astronómico de La Plata - Sede Central; ArgentinaFil: del Palacio, Santiago. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomía; ArgentinaFil: Ishwara-Chandra, C. H.. International Centre Of Theoretical Science. Tata Institute Of Fundamental Research; EspañaFil: De Becker, M.. Université de Liège; BélgicaFil: Isequilla, Natacha Laura. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Observatorio Astronómico de La Plata - Sede Central; ArgentinaFil: Saponara, Juliana. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Argentino de Radioastronomía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Argentino de Radioastronomía; Argentin

Thermal, electric and durability characterization of supercaps for energy back-up of automotive ECU

A new generation of mechatronic devices, such as the E-latch for door closure, is introduced in the automotive field to replace mechanical systems with electro-actuated parts with embedded electronic control unit (ECU) connected to the main vehicle network. Due to severe automotive safety-critical requirements an energy back-up solution is proposed, based on supercaps and boost converter, to ensure E-latch operation even in case of main battery failure. An in-depth thermal, electrical and durability characterization of the supercaps proves the suitability of the energy back-up unit for automotive applications

Primary malignant pericardial tumour in Lynch syndrome

Background: This case represents the first report of malignant primary cardiac tumour in a patient with Lynch Syndrome associated with MSH2 pathogenic variant. Case presentation: A 57-year-old woman with previous ovarian cystadenocarcinoma was admitted to the emergency room for hematic pericardial effusion. Multimodal diagnostic imaging revealed two solid pericardial vascularized masses. After pericardiectomy, the final histological diagnosis was poorly differentiated pleomorphic sarcomatoid carcinoma. During follow-up she developed an ampulla of Vater adenocarcinoma. Genetic analysis identified an MSH2 pathogenic variant. Conclusion: This case contributes to expand the tumour spectrum of Lynch syndrome, suggesting that MSH2 pathogenic variants cause a more complex multi-tumour cancer syndrome than the classic Lynch Syndrome. In MSH2 variant carriers, symptoms such as dyspnoea and chest discomfort might alert for rare tumours and a focused cardiac evaluation should be considered

Testing silicon photonic Mach–Zehnder modulators versus total ionizing dose

Silicon photonics is emerging as a key technology for developing radiation-tolerant optical transceivers. In this work, we present the electro-optical characterization of two radiation-hardened shallow-etched Mach–Zehnder modulators with different doping configurations when exposed to 1.2 Grad(SiO2) total ionizing dose. The trade-offs between radiation hardness and nominal performance metrics are highlighted to provide insights for optimizing SiPh devices for high-energy physics applications

A novel combinatory treatment against a CDDP-resistant non-small cell lung cancer based on a Ruthenium(II)-cyclopentadienyl compound

The therapeutic approach to many solid tumors, including non-small cell lung cancer (NSCLC), is mainly based on the use of platinum-containing anticancer agents and is often characterized by acquired or intrinsic resistance to the drug. Therefore, the search for safer and more effective drugs is still an open challenge. Two organometallic ruthenium(II)-cyclopentadienyl compounds [Ru(eta(5)-C5H4CHO)(Me(2)bipy)(PPh3)]+ (RT150) and [Ru(eta(5)-C5H4CH2OH)(Me(2)bipy)(PPh3)][CF3SO3] (RT151) were tested against a panel of cisplatinresistant NSCLC cell lines and xenografts. They were more effective than cisplatin in inducing oxidative stress and DNA damage, affecting the cell cycle and causing apoptosis. Importantly, they were found to be inhibitors of drug efflux transporters. Due to this property, the compounds significantly increased the retention and cytotoxicity of cisplatin within NSCLC cells. Notably, they did not display high toxicity in vitro against nontransformed cells (red blood cells, fibroblasts, bronchial epithelial cells, cardiomyocytes, and endothelial cells). Both compounds induced vasorelaxation and reduced endothelial cell migration, suggesting potential antiangiogenic properties. RT151 confirmed its efficacy against NSCLC xenografts resistant to cisplatin. Either alone or combined with low doses of cisplatin, RT151 showed a good biodistribution profile in the liver, kidney, spleen, lung, and tumor. Hematochemical analysis and post-mortem organ pathology confirmed the safety of the compound in vivo, also when combined with cisplatin. To sum up, we have confirmed the effectiveness of a novel class of drugs against cisplatin-resistant NSCLC. Additionally, the compounds have a good biocompatibility and safety profile