253 research outputs found
Colored Tverberg Theorems for non-prime powers
We prove a relative of the Optimal (Type B)} Colored Tverberg theorem of
\v{Z}ivaljevi\'{c} and Vre\'{c}ica which modifies this results in two different
ways. (1) Our result is valid if the number of rainbow faces is ,
where is a prime. (2) The size of rainbow simplices satisfies the condition
while in the original theorem for all .Comment: arXiv admin note: text overlap with arXiv:2210.09101,
arXiv:2210.0780
Synthetic organotelluride compounds induce the reversal of Pdr5p mediated fluconazole resistance in Saccharomyces cerevisiae
Background: Resistance to fluconazole, a commonly used azole antifungal, is a challenge for the treatment of fungal infections. Resistance can be mediated by overexpression of ABC transporters, which promote drug efflux that requires ATP hydrolysis. the Pdr5p ABC transporter of Saccharomyces cerevisiae is a well-known model used to study this mechanism of antifungal resistance. the present study investigated the effects of 13 synthetic compounds on Pdr5p.Results: Among the tested compounds, four contained a tellurium-butane group and shared structural similarities that were absent in the other tested compounds: a lateral hydrocarbon chain and an amide group. These four compounds were capable of inhibiting Pdr5p ATPase activity by more than 90%, they demonstrated IC50 values less than 2 M and had an uncompetitive pattern of Pdr5p ATPase activity inhibition. These organotellurides did not demonstrate cytotoxicity against human erythrocytes or S. cerevisiae mutant strains (a strain that overexpress Pdr5p and a null mutant strain) even in concentrations above 100 mu M. When tested at 100 mu M, they could reverse the fluconazole resistance expressed by both the S. cerevisiae mutant strain that overexpress Pdr5p and a clinical isolate of Candida albicans.Conclusions: We have identified four organotellurides that are promising candidates for the reversal of drug resistance mediated by drug efflux pumps. These molecules will act as scaffolds for the development of more efficient and effective efflux pump inhibitors that can be used in combination therapy with available antifungals.Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)University of São Paulo through the NAP-CatSinQ (Research Core in Catalysis and Chemical Synthesis)Univ Fed Rio de Janeiro, CCS, Inst Microbiol Paulo Goes, Dept Microbiol Geral,Lab Bioquim Microbiana, Rio de Janeiro, RJ, BrazilUniv São Paulo, Inst Quim, Dept Quim Fundamental, São Paulo, BrazilInst Fed Educ Ciencia & Tecnol Rio de Janeiro IFR, Rio de Janeiro, RJ, BrazilUniversidade Federal de São Paulo UNIFESP, Inst Ciencias Ambientais Quim & Farmaceut, São Paulo, BrazilUniversidade Federal de São Paulo UNIFESP, Inst Ciencias Ambientais Quim & Farmaceut, São Paulo, BrazilFAPERJ: E-26/111.338/2013FAPESP: 2005/59572-7FAPESP: 2008/55401-1FAPESP: 2010/17228-6FAPESP: 2011/03244-2FAPESP: 2011/11613-8FAPESP: 2012/17093-9CNPq: 470360/2012-7Web of Scienc
Obtençao de DNA genômico e RNA total de Leucoptera coffeella para sequenciamento gênico de alta fidelidade.
Estratégias de recuperação de pastagens em solos arenosos do Cerrado da Bahia.
Esta publicação apresenta as estratégias de recuperação de pastagens utilizadas pela fazenda e pela equipe do Projeto Trijunção, buscando a intensificação sustentável da produção. Dessa forma, será apresentado o histórico de uso das áreas da Fazenda Santa Luzia, localizada na região do Cerrado da Bahia, bem como os resultados do uso de estratégias de recuperação. Esta publicação contribui com o Objetivo de Desenvolvimento Sustentável 2 (ODS 2 ? ?Fome Zero e Agricultura Sustentável?), contido na Agenda 2030, proposta pela Organização das Nações Unidas. Foca mais especificamente na Meta 2.4: ?garantir sistemas sustentáveis de produção de alimentos e implementar práticas agrícolas resilientes, que aumentem a produtividade e a produção, que ajudem a manter os ecossistemas, que fortaleçam a capacidade de adaptação às mudanças climáticas, às condições meteorológicas extremas, secas, inundações e outros desastres, e que melhorem progressivamente a qualidade da terra e do solo?.ODS 2
Otimização de protocolo de extração de DNA genômico do bicho-mineiro do cafeeiro (Leucoptera coffeella) para sequenciamento Long-Read.
Fiber Optical Cable and Connector System (FOCCoS) for PFS/Subaru
FOCCoS, Fiber Optical Cable and Connector System, has the main function of
capturing the direct light from the focal plane of Subaru Telescope using
optical fibers, each one with a microlens in its tip, and conducting this light
through a route containing connectors to a set of four spectrographs. The
optical fiber cable is divided in 3 different segments called Cable A, Cable B
and Cable C. Multi-fibers connectors assure precise connection among all
optical fibers of the segments, providing flexibility for instrument changes.
To assure strong and accurate connection, these sets are arranged inside two
types of assemblies: the Tower Connector, for connection between Cable C and
Cable B; and the Gang Connector, for connection between Cable B and Cable A.
Throughput tests were made to evaluate the efficiency of the connections. A
lifetime test connection is in progress. Cable C is installed inside the PFI,
Prime Focus Instrument, where each fiber tip with a microlens is bonded to the
end of the shaft of a 2-stage piezo-electric rotatory motor positioner; this
assembly allows each fiber to be placed anywhere within its patrol region,
which is 9.5mm diameter.. Each positioner uses a fiber arm to support the
ferrule, the microlens, and the optical fiber. 2400 of these assemblies are
arranged on a motor bench plate in a hexagonal-closed-packed disposition.Comment: 11 pages, 20 figure
Application of modified simplex on the development of a preconcentration system for cadmium determination in sediments, food and cigarettes
Data standardization of plant–pollinator interactions
Background: Animal pollination is an important ecosystem function and service, ensuring both the integrity of natural systems
and human well-being. Although many knowledge shortfalls remain, some high-quality data sets on biological interactions are now
available. The development and adoption of standards for biodiversity data and metadata has promoted great advances in biological
data sharing and aggregation, supporting large-scale studies and science-based public policies. However, these standards are currently
not suitable to fully support interaction data sharing.
Results: Here we present a vocabulary of terms and a data model for sharing plant–pollinator interactions data based on the Darwin
Core standard. The vocabulary introduces 48 new terms targeting several aspects of plant–pollinator interactions and can be used to
capture information from different approaches and scales. Additionally, we provide solutions for data serialization using RDF, XML,
and DwC-Archives and recommendations of existing controlled vocabularies for some of the terms. Our contribution supports open
access to standardized data on plant–pollinator interactions.
Conclusions: The adoption of the vocabulary would facilitate data sharing to support studies ranging from the spatial and temporal
distribution of interactions to the taxonomic, phenological, functional, and phylogenetic aspects of plant–pollinator interactions. We
expect to fill data and knowledge gaps, thus further enabling scientific research on the ecology and evolution of plant–pollinator
communities, biodiversity conservation, ecosystem services, and the development of public policies. The proposed data model is
flexible and can be adapted for sharing other types of interactions data by developing discipline-specific vocabularies of termsinfo:eu-repo/semantics/publishedVersio
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