713 research outputs found
Anti-inflammatory, antinociceptive, and antipyretic effects of methanol extract of Cariniana rubra stem bark in animal models
Schmeda-Hirschmann, G (Schmeda-Hirschmann, Guillermo) Univ Talca, IQRN, Talca, ChileCariniana rubra Miers (Lecythidaceae), popularly known as "jequitiba-vermelho", is a large Brazilian tree whose bark is used in infusion and decoction for the treatment of inflammatory conditions. This study aims to assess the anti-inflammatory, antinociceptive, and antipyretic effects of Cariniana rubra methanolic stem bark extract (EMCr) using experimental animals. Anti-inflammatory activity of EMCr was tested on carrageenan and dextran-induced rat paw edema, carrageenan-induced pleurisy in rats and acetic acid-increase vascular permeability in mice. Antinociceptive and antipyretic activities were evaluated using acetic acid-induced writhing, formalin and hot-plate tests in mice, as well as brewer's yeast-induced pyrexia in rats. The extract inhibitied carrageenan and dextran-induced edema, reduced exudate volume and leukocyte migration on the carrageenan-induced pleurisy and on the vascular permeability increase induced by acetic acid. The EMCr inhibited nociception on the acetic acid-induced writhing and in the second phase of formalin test, and decreased rectal temperature. It was, however, inactive against thermal nociception. Phytochemical analysis with EMCr showed the occurrence of saponins, triterpenes, sterols and phenolic compounds. Phytosterols (beta-sitosterol, stigmasterol), pentacyclic triterpenes (alpha- and beta-amyrin as a mixture), arjunolic acid, a phytosterol glycoside (sitosterol 3-O-beta-D-glucopyranoside), and triterpenoid saponins (28-beta-glucopyranosyl-23-O-acetyl arjunolic acid; 3-O-beta-glucopyranosyl arjunolic acid and 28-O-[alpha-L-Rhamnopyranosyl-(1 -> 2)-beta-glucopyranosyl]-23-O-acetyl arjunolic acid) were the main identified compounds. It can be presumed that EMCr caused their effects by inhibiting the liberation and/or action of different inflammatory mediators. These findings support the traditional use of Cariniana rubra preparations to treat inflammation
Collapsing Spheres Satisfying An "Euclidean Condition"
We study the general properties of fluid spheres satisfying the heuristic
assumption that their areas and proper radius are equal (the Euclidean
condition). Dissipative and non-dissipative models are considered. In the
latter case, all models are necessarily geodesic and a subclass of the
Lemaitre-Tolman-Bondi solution is obtained. In the dissipative case solutions
are non-geodesic and are characterized by the fact that all non-gravitational
forces acting on any fluid element produces a radial three-acceleration
independent on its inertial mass.Comment: 1o pages, Latex. Title changed and text shortened to fit the version
to appear in Gen.Rel.Grav
Stationary Cylindrical Anisotropic Fluid
We present the whole set of equations with regularity and matching conditions
required for the description of physically meaningful stationary cylindrically
symmmetric distributions of matter, smoothly matched to Lewis vacuum spacetime.
A specific example is given. The electric and magnetic parts of the Weyl tensor
are calculated, and it is shown that purely electric solutions are necessarily
static. Then, it is shown that no conformally flat stationary cylindrical fluid
exits, satisfying regularity and matching conditions.Comment: 17 pages Latex. To appear in Gen.Rel.Gra
Energetics of the Einstein-Rosen spacetime
A study covering some aspects of the Einstein--Rosen metric is presented. The
electric and magnetic parts of the Weyl tensor are calculated. It is shown that
there are no purely magnetic E--R spacetimes, and also that a purely electric
E--R spacetime is necessarily static. The geodesics equations are found and
circular ones are analyzed in detail. The super--Poynting and the
``Lagrangian'' Poynting vectors are calculated and their expressions are found
for two specific examples. It is shown that for a pulse--type solution, both
expressions describe an inward radially directed flow of energy, far behind the
wave front. The physical significance of such an effect is discussed.Comment: 19 pages Latex.References added and updated.To appear in
Int.J.Theor.Phy
Spherically symmetric dissipative anisotropic fluids: A general study
The full set of equations governing the evolution of self--gravitating
spherically symmetric dissipative fluids with anisotropic stresses is deployed
and used to carry out a general study on the behaviour of such systems, in the
context of general relativity. Emphasis is given to the link between the Weyl
tensor, the shear tensor, the anisotropy of the pressure and the density
inhomogeneity. In particular we provide the general, necessary and sufficient,
condition for the vanishing of the spatial gradients of energy density, which
in turn suggests a possible definition of a gravitational arrow of time. Some
solutions are also exhibited to illustrate the discussion.Comment: 28 pages Latex. To appear in Phys.Rev.
A novel form of deleted in breast cancer 1 (DBC1) lacking the N-terminal domain does not bind SIRT1 and is dynamically regulated in vivo
The protein Deleted in Breast Cancer-1 is a regulator of several transcription factors and epigenetic regulators, including HDAC3, Rev-erb-alpha, PARP1 and SIRT1. It is well known that DBC1 regulates its targets, including SIRT1, by protein-protein interaction. However, little is known about how DBC1 biological activity is regulated. In this work, we show that in quiescent cells DBC1 is proteolytically cleaved, producing a protein (DN-DBC1) that misses the S1-like domain and no longer binds to SIRT1. DN-DBC1 is also found in vivo in mouse and human tissues. Interestingly, DN-DBC1 is cleared once quiescent cells re-enter to the cell cycle. Using a model of liver regeneration after partial hepatectomy, we found that DN-DBC1 is down-regulated in vivo during regeneration. In fact, WT mice show a decrease in SIRT1 activity during liver regeneration, coincidentally with DN-DBC1 downregulation and the appearance of full length DBC1. This effect on SIRT1 activity was not observed in DBC1 KO mice. Finally, we found that DBC1 KO mice have altered cell cycle progression and liver regeneration after partial hepatectomy, suggesting that DBC1/DN-DBC1 transitions play a role in normal cell cycle progression in vivo after cells leave quiescence. We propose that quiescent cells express DN-DBC1, which either replaces or coexist with the full-length protein, and that restoring of DBC1 is required for normal cell cycle progression in vitro and in vivo. Our results describe for the first time in vivo a naturally occurring form of DBC1, which does not bind SIRT1 and is dynamically regulated, thus contributing to redefine the knowledge about its function
Theory and Applications of Non-Relativistic and Relativistic Turbulent Reconnection
Realistic astrophysical environments are turbulent due to the extremely high
Reynolds numbers. Therefore, the theories of reconnection intended for
describing astrophysical reconnection should not ignore the effects of
turbulence on magnetic reconnection. Turbulence is known to change the nature
of many physical processes dramatically and in this review we claim that
magnetic reconnection is not an exception. We stress that not only
astrophysical turbulence is ubiquitous, but also magnetic reconnection itself
induces turbulence. Thus turbulence must be accounted for in any realistic
astrophysical reconnection setup. We argue that due to the similarities of MHD
turbulence in relativistic and non-relativistic cases the theory of magnetic
reconnection developed for the non-relativistic case can be extended to the
relativistic case and we provide numerical simulations that support this
conjecture. We also provide quantitative comparisons of the theoretical
predictions and results of numerical experiments, including the situations when
turbulent reconnection is self-driven, i.e. the turbulence in the system is
generated by the reconnection process itself. We show how turbulent
reconnection entails the violation of magnetic flux freezing, the conclusion
that has really far reaching consequences for many realistically turbulent
astrophysical environments. In addition, we consider observational testing of
turbulent reconnection as well as numerous implications of the theory. The
former includes the Sun and solar wind reconnection, while the latter include
the process of reconnection diffusion induced by turbulent reconnection, the
acceleration of energetic particles, bursts of turbulent reconnection related
to black hole sources as well as gamma ray bursts. Finally, we explain why
turbulent reconnection cannot be explained by turbulent resistivity or derived
through the mean field approach.Comment: 66 pages, 24 figures, a chapter of the book "Magnetic Reconnection -
Concepts and Applications", editors W. Gonzalez, E. N. Parke
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