Nitric Oxide Regulates Neurogenesis in the Hippocampus following Seizures

Hippocampal neurogenesis is changed by brain injury. When neuroinflammation accompanies injury, activation of resident microglial cells promotes the release of inflammatory cytokines and reactive oxygen/nitrogen species like nitric oxide (NO). In these conditions, NO promotes proliferation of neural stem cells (NSC) in the hippocampus. However, little is known about the role of NO in the survival and differentiation of newborn cells in the injured dentate gyrus. Here we investigated the role of NO following seizures in the regulation of proliferation, migration, differentiation, and survival of NSC in the hippocampus using the kainic acid (KA) induced seizuremouse model. We show that NO increased the proliferation of NSC and the number of neuroblasts following seizures but was detrimental to the survival of newborn neurons. NO was also required for the maintenance of long-term neuroinflammation. Taken together, our data show that NO positively contributes to the initial stages of neurogenesis following seizures but compromises survival of newborn neurons.Foundation for Science and Technology (FCT, Portugal); COMPETE; FEDER [PTDC/SAU-NEU/102612/2008, PTDC/NEU-OSD/0473/2012, PEst-C/SAU/LA0001/2013-2014, PEst-OE/EQB/LA0023/2013-2014]; FCT, Portugal [SFRH/BPD/78901/2011, SFRH/BD/77903/2011

Editorial: Driving, cycling and flying: trends in planning and operational transportation research in Europe

In this special issue we present three papers selected from the 18th meeting of the EURO Working Group on Transportation (EWGT) which was held in July 2015 in Delft, the Netherlands, organized by Delft University of Technology. The selected contributions reflect the diversity of topics that were addressed in this conference, which is dedicated to mathematical modeling of transportation problems. We are happy to have a small but representative sample in which three different modes of transportation are in focus: the bicycle, the car and the airplane. The editors are very grateful for all the work that authors and referees have put in creating interesting research papers in this broad field of transportation research. This editorial first explains what the EWGT is and how the EWGT conference was organized. The three contributions are then presented and put into the perspective of the Dutch edition of the EWGT conference

Studies of transport coefficients in charged AdS4_{4} black holes on κ\kappa-deformed space

In this work, we study the effect of $\kappa$-deformed space on the thermodynamic quantities, this are find through the holographic renormalization that provide the free energy, which is fundamental to derive the another thermodynamic quantities. For this scenario we consider an charged AdS$_{4}$ black hole for an Einstein-Maxwell model where the derivative quadrivector is replaced by a deformed version inspired in Kaniadakis statistics. Besides, we extract the transport coefficient know as electrical conductivity.Comment: 5 pages, 8 figure

FOXO family isoforms

FOXO family of proteins are transcription factors involved in many physiological and pathological processes including cellular homeostasis, stem cell maintenance, cancer, metabolic, and cardiovascular diseases. Genetic evidence has been accumulating to suggest a prominent role of FOXOs in lifespan regulation in animal systems from hydra, C elegans, Drosophila, and mice. Together with the observation that FOXO3 is the second most replicated gene associated with extreme human longevity suggests that pharmacological targeting of FOXO proteins can be a promising approach to treat cancer and other age-related diseases and extend life and health span. However, due to the broad range of cellular functions of the FOXO family members FOXO1, 3, 4, and 6, isoform-specific targeting of FOXOs might lead to greater benefits and cause fewer side effects. Therefore, a deeper understanding of the common and specific features of these proteins as well as their redundant and specific functions in our cells represents the basis of specific targeting strategies. In this review, we provide an overview of the evolution, structure, function, and disease-relevance of each of the FOXO family members.Agencia Estatal de Investigation and the European Regional Development Fund (PID2022-136654OB-I00 financed by MCIN/AEI /10.13039/501100011033 / FEDER, UE).info:eu-repo/semantics/publishedVersio

Tribbles pseudokinases in colorectal cancer

The Tribbles family of pseudokinases controls a wide number of processes during cancer on-set and progression. However, the exact contribution of each of the three family members is still to be defined. Their function appears to be context-dependent as they can act as oncogenes or tumor suppressor genes. They act as scaffolds modulating the activity of several signaling pathways involved in different cellular processes. In this review, we discuss the state-of-knowledge for TRIB1, TRIB2 and TRIB3 in the development and progression of colorectal cancer. We take a perspective look at the role of Tribbles proteins as potential biomarkers and therapeutic targets. Specifically, we chronologically systematized all available articles since 2003 until 2020, for which Tribbles were associated with colorectal cancer human samples or cell lines. Herein, we discuss: (1) Tribbles amplification and overexpression; (2) the clinical significance of Tribbles overexpression; (3) upstream Tribbles gene and protein expression regulation; (4) Tribbles pharmacological modulation; (5) genetic modulation of Tribbles; and (6) downstream mechanisms regulated by Tribbles; establishing a comprehensive timeline, essential to better consolidate the current knowledge of Tribbles’ role in colorectal cancer.Project TRIBBLES–748585 e Fundação para a Ciência e a Tecnologia (FCT) (PTDC/MEDONC/4167/2020 “ENDURING”)info:eu-repo/semantics/publishedVersio