Modified Green's Functions for Shallow Water Acoustic Wave Propagation

This article presents an assessment of alternative forms of the Green’s function for boundary element simulations of acoustic wave propagation in shallow water. It is assumed that the problem is two-dimensional, the source of acoustic disturbance is time-harmonic, the velocity of sound is constant and the medium in the absence of perturbations is quiescent. Efficient implementations of the boundary element method for underwater acoustics should employ Green's functions which directly satisfy the boundary conditions on the free surface and the horizontal parts of the bottom boundary. In the present work, these Green's functions are constructed by using different techniques, namely the method of images, eigenfunction expansions and the Ewald’s method

Microscopic phenomena and a modern approach to turbulence

The use of an arc driven shock tube as a technique in the study of turbulence and evidence to support a kinetic theory of turbulence are described. Topics covered include: (1) reaction rate distortion in turbulent flow; (2) turbulent bursts in a shock tube; (3) driver gas flow with fluctuations; (4) improving the Mach number capabilities of arc driver shock tubes; and (5) resonant absorption in an argon plasma at thermal equilibrium

A HEV-restricted sulfotransferase is expressed in rheumatoid arthritis synovium and is induced by lymphotoxin-alpha/beta and TNF-alpha in cultured endothelial cells.

BackgroundThe recruitment of lymphocytes to secondary lymphoid organs relies on interactions of circulating cells with high endothelial venules (HEV). HEV are exclusive to these organs under physiological conditions, but they can develop in chronically-inflamed tissues. The interaction of L-selectin on lymphocytes with sulfated glycoprotein ligands on HEV results in lymphocyte rolling, which represents the initial step in lymphocyte homing. HEV expression of GlcNAc6ST-2 (also known as HEC-GlcNAc6ST, GST-3, LSST or CHST4), an HEV-restricted sulfotransferase, is essential for the elaboration of L-selectin functional ligands as well as a critical epitope recognized by MECA-79 mAb.ResultsWe examined the expression of GlcNAc6ST-2 in relationship to the MECA-79 epitope in rheumatoid arthritis (RA) synovial vessels. Expression of GlcNAc6ST-2 was specific to RA synovial tissues as compared to osteoarthritis synovial tissues and localized to endothelial cells of HEV-like vessels and small flat-walled vessels. Double MECA-79 and GlcNAc6ST-2 staining showed colocalization of the MECA-79 epitope and GlcNAc6ST-2. We further found that both TNF-alpha and lymphotoxin-alphabeta induced GlcNAc6ST-2 mRNA and protein in cultured human umbilical vein endothelial cells.ConclusionThese observations demonstrate that GlcNAc6ST-2 is induced in RA vessels and provide potential cytokine pathways for its induction. GlcNAc6ST-2 is a novel marker of activated vessels within RA ectopic lymphoid aggregates. This enzyme represents a potential therapeutic target for RA

Noninfectious retrovirus particles drive the APOBEC3/Rfv3 dependent neutralizing antibody response.

Members of the APOBEC3 family of deoxycytidine deaminases counteract a broad range of retroviruses in vitro through an indirect mechanism that requires virion incorporation and inhibition of reverse transcription and/or hypermutation of minus strand transcripts in the next target cell. The selective advantage to the host of this indirect restriction mechanism remains unclear, but valuable insights may be gained by studying APOBEC3 function in vivo. Apobec3 was previously shown to encode Rfv3, a classical resistance gene that controls the recovery of mice from pathogenic Friend retrovirus (FV) infection by promoting a more potent neutralizing antibody (NAb) response. The underlying mechanism does not involve a direct effect of Apobec3 on B cell function. Here we show that while Apobec3 decreased titers of infectious virus during acute FV infection, plasma viral RNA loads were maintained, indicating substantial release of noninfectious particles in vivo. The lack of plasma virion infectivity was associated with a significant post-entry block during early reverse transcription rather than G-to-A hypermutation. The Apobec3-dependent NAb response correlated with IgG binding titers against native, but not detergent-lysed virions. These findings indicate that innate Apobec3 restriction promotes NAb responses by maintaining high concentrations of virions with native B cell epitopes, but in the context of low virion infectivity. Finally, Apobec3 restriction was found to be saturable in vivo, since increasing FV inoculum doses resulted in decreased Apobec3 inhibition. By analogy, maximizing the release of noninfectious particles by modulating APOBEC3 expression may improve humoral immunity against pathogenic human retroviral infections

Void Statistics in Large Galaxy Redshift Surveys: Does Halo Occupation of Field Galaxies Depend on Environment?

We use measurements of the projected galaxy correlation function w_p and galaxy void statistics to test whether the galaxy content of halos of fixed mass is systematically different in low density environments. We present new measurements of the void probability function (VPF) and underdensity probability function (UPF) from Data Release Four of the Sloan Digital Sky Survey, as well as new measurements of the VPF from the full data release of the Two-Degree Field Galaxy Redshift Survey. We compare these measurements to predictions calculated from models of the Halo Occupation Distribution (HOD) that are constrained to match both w_p and the space density of galaxies. The standard implementation of the HOD assumes that galaxy occupation depends on halo mass only, and is independent of local environment. For luminosity-defined samples, we find that the standard HOD prediction is a good match to the observations, and the data exclude models in which galaxy formation efficiency is reduced in low-density environments. More remarkably, we find that the void statistics of red and blue galaxies (at L ~ 0.4L_*) are perfectly predicted by standard HOD models matched to the correlation function of these samples, ruling out "assembly bias" models in which galaxy color is correlated with large-scale environment at fixed halo mass. We conclude that the luminosity and color of field galaxies are determined predominantly by the mass of the halo in which they reside and have little direct dependence on the environment in which the host halo formed. In broader terms, our results show that the sizes and emptiness of voids found in the distribution of L > 0.2L_* galaxies are in excellent agreement with the predictions of a standard cosmological model with a simple connection between galaxies and dark matter halos. (abridged)Comment: 20 emulateapj pages, 9 figures. submitted to Ap

Cylindrically symmetric spinning Brans-Dicke spacetimes with closed timelike curves

We present here three new solutions of Brans-Dicke theory for a stationary geometry with cylindrical symmetry in the presence of matter in rigid rotation with $T^\mu_\mu\neq 0$. All the solutions have eternal closed timelike curves in some region of the spacetime, the size of which depends on $\omega$. Moreover, two of them do not go over a solution of general relativity in the limit $\omega \to \infty$.Comment: revtex, 10 pages, 1 figure in p

Etiologia, fatores de risco e aspectos clínicos da mastite ovina.

bitstream/CNPC-2010/22751/1/doc87.pd