9 research outputs found
Quantum Physics Exploring Gravity in the Outer Solar System: The Sagas Project
We summarise the scientific and technological aspects of the SAGAS (Search
for Anomalous Gravitation using Atomic Sensors) project, submitted to ESA in
June 2007 in response to the Cosmic Vision 2015-2025 call for proposals. The
proposed mission aims at flying highly sensitive atomic sensors (optical clock,
cold atom accelerometer, optical link) on a Solar System escape trajectory in
the 2020 to 2030 time-frame. SAGAS has numerous science objectives in
fundamental physics and Solar System science, for example numerous tests of
general relativity and the exploration of the Kuiper belt. The combination of
highly sensitive atomic sensors and of the laser link well adapted for large
distances will allow measurements with unprecedented accuracy and on scales
never reached before. We present the proposed mission in some detail, with
particular emphasis on the science goals and associated measurements.Comment: 39 pages. Submitted in abridged version to Experimental Astronom
Serum IL-6, sAXL, and YKL-40 as systemic correlates of reduced brain structure and function in Alzheimer’s disease: results from the DELCODE study
Background
Neuroinflammation constitutes a pathological hallmark of Alzheimer’s disease (AD). Still, it remains unresolved if peripheral inflammatory markers can be utilized for research purposes similar to blood-based beta-amyloid and neurodegeneration measures. We investigated experimental inflammation markers in serum and analyzed interrelations towards AD pathology features in a cohort with a focus on at-risk stages of AD.
Methods
Data of 74 healthy controls (HC), 99 subjective cognitive decline (SCD), 75 mild cognitive impairment (MCI), 23 AD relatives, and 38 AD subjects were obtained from the DELCODE cohort. A panel of 20 serum biomarkers was determined using immunoassays. Analyses were adjusted for age, sex, APOE status, and body mass index and included correlations between serum and CSF marker levels and AD biomarker levels. Group-wise comparisons were based on screening diagnosis and routine AD biomarker-based schematics. Structural imaging data were combined into composite scores representing Braak stage regions and related to serum biomarker levels. The Preclinical Alzheimer’s Cognitive Composite (PACC5) score was used to test for associations between the biomarkers and cognitive performance.
Results
Each experimental marker displayed an individual profile of interrelations to AD biomarkers, imaging, or cognition features. Serum-soluble AXL (sAXL), IL-6, and YKL-40 showed the most striking associations. Soluble AXL was significantly elevated in AD subjects with pathological CSF beta-amyloid/tau profile and negatively related to structural imaging and cognitive function. Serum IL-6 was negatively correlated to structural measures of Braak regions, without associations to corresponding IL-6 CSF levels or other AD features. Serum YKL-40 correlated most consistently to CSF AD biomarker profiles and showed the strongest negative relations to structure, but none to cognitive outcomes.
Conclusions
Serum sAXL, IL-6, and YKL-40 relate to different AD features, including the degree of neuropathology and cognitive functioning. This may suggest that peripheral blood signatures correspond to specific stages of the disease. As serum markers did not reflect the corresponding CSF protein levels, our data highlight the need to interpret serum inflammatory markers depending on the respective protein’s specific biology and cellular origin. These marker-specific differences will have to be considered to further define and interpret blood-based inflammatory profiles for AD research