613 research outputs found
Synthesis of Conjugated Polymer Based in Zn(II) Porphyrin Bearing Terminal Alkynyl Groups as Photosensitizer
5,10,15,20-tetrakis-[4-(ethynyl)phenyl]porphyrin (TEP) was synthesized from the condensation of 4-(ethynyl)benzaldehyde and pyrrole catalyzed by boron trifluoride diethyl etherate in dichloromethane (DCM). After oxidation with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone and purification, TEP was obtained in 34% yield. This porphyrin was metaled with Zn(II) acetate in DCM/methanol to produce the complex ZnTEP in 98% yield. A homocoupling reaction of terminal alkynes of ZnTEP to diynes was used to synthesize conjugated polymer organogel (ZnTEPP). The reaction was co-catalyzed by PdCl2(PPh3)2 and CuI in tetrahydrofuran. The solvent was evaporated to obtain xerogel and the SEM images showed microporous structure. In addition, spectroscopic and photodynamic studies of ZnTEPP indicated that the porphyrin unit retains its properties as a photosensitizer. Thus, this polymer is an interesting material with potential applications in forming photoactive aseptic surfaces.Fil: Santamarina, Sofia Carla. Universidad Nacional de RĂo Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; ArgentinaFil: Heredia, Daniel Alejandro. Universidad Nacional de RĂo Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; ArgentinaFil: Durantini, Andres MatĂas. Universidad Nacional de RĂo Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; ArgentinaFil: Durantini, Edgardo NĂ©stor. Universidad Nacional de RĂo Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentin
BODIPYs bearing a dimethylaminopropoxy substituent for imaging and photodynamic inactivation of bacteria
A new BODIPY (BDP 1) bearing a dimethylaminopropoxy group attached to a phenylene unit was synthesized. This compound was brominated to obtain the halogenated analog BDP 2, which was designed to enhance the photodynamic effect of BODIPY to kill bacteria without an intrinsic cationic charge. The basic amino group located at the end of the propoxy bridge can acquire a positive charge by protonation in an aqueous medium, increasing the binding to bacterial cells. Interaction and photokilling activity mediated by these compounds was evaluated in Staphylococcus aureus and Escherichia coli. BDP 1 and BDP 2 were rapidly bound to bacterial cells, showing bioimages with green emission. Complete elimination of S. aureus was detected when cells were incubated with 1 ÎŒM BDP 2 and irradiated for 5 min. Comparable photoinactivation was obtained with E. coli, after an irradiation of 30 min. Furthermore, BDP 2 was effective to kill bacteria at very low concentration (0.5 ÎŒM). Thus, BDP 1 showed mainly interesting properties as a fluorophore, whereas BDP 2 was highly effective photosensitizer as a broad-spectrum antibacterial agent.Fil: Palacios, Yohana BelĂ©n. Universidad Nacional de RĂo Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas FisicoquĂmicas y Naturales. Departamento de QuĂmica; ArgentinaFil: Santamarina, Sofia Carla. Universidad Nacional de RĂo Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas FisicoquĂmicas y Naturales. Departamento de QuĂmica; ArgentinaFil: Durantini, Javier Esteban. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas FisicoquĂmicas y Naturales. Instituto de Investigaciones en TecnologĂas EnergĂ©ticas y Materiales Avanzados. - Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto de Investigaciones en TecnologĂas EnergĂ©ticas y Materiales Avanzados; Argentina. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas FisicoquĂmicas y Naturales. Departamento de QuĂmica; ArgentinaFil: Durantini, Edgardo NĂ©stor. Universidad Nacional de RĂo Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas FisicoquĂmicas y Naturales. Departamento de QuĂmica; ArgentinaFil: Durantini, Andres MatĂas. Universidad Nacional de RĂo Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas FisicoquĂmicas y Naturales. Departamento de QuĂmica; Argentin
Light-Activated Antibacterial Polymeric Surface Based on Porphycene
A photoactivatable antimicrobial polymeric surface based on a porphycene derivate was efficiently prepared and evaluated to kill pathogenic microorganisms. The development of this self-sterilizing material consisted in the electrochemical polymerization of a peripherally tetra-substituted porphycene bearing benzyl-carbazole groups (Pc-Cbz). The latter were used as electropolymerizable centers, while the porphycene core triggered the photodynamic action. The electrodeposited photodynamic films (P-Pc-Cbz) were obtained in a reproducible and controllable manner. Electrochemistry studies combined with spectroscopic measurements demonstrated that the porphycene core remains unaffected after the electrodeposition process. Moreover, it retains its spectroscopic and photodynamic properties within the polymeric matrix. The photoactive layers were photostable and able to produce reactive oxygen species (ROS) by both photodynamic mechanisms. Also, the antimicrobial efficiency of P-Pc-Cbz was evaluated against two antibiotic-resistant strains (methicillin-resistant Staphylococcus aureus and Escherichia coli), exhibiting an antimicrobial action higher than 99.998% over these Gram-positive and Gram-negative bacteria. This work represents the first electropolymerization of a porphycene derivative and the first porphycene-based photobiocidal surface. P-Pc-Cbz shows great potential as an efficient self-sterilizing coating activated by visible light.Fil: Gonzalez Lopez, Edwin Javier. Universidad Nacional de RĂo Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; ArgentinaFil: Renfige Rodriguez, Yone Melisa. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas FisicoquĂmicas y Naturales. Instituto de Investigaciones en TecnologĂas EnergĂ©ticas y Materiales Avanzados. - Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto de Investigaciones en TecnologĂas EnergĂ©ticas y Materiales Avanzados; ArgentinaFil: Santamarina, Sofia Carla. Universidad Nacional de RĂo Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; ArgentinaFil: Macor, Lorena Paola. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas FisicoquĂmicas y Naturales. Instituto de Investigaciones en TecnologĂas EnergĂ©ticas y Materiales Avanzados. - Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto de Investigaciones en TecnologĂas EnergĂ©ticas y Materiales Avanzados; ArgentinaFil: Otero, Luis Alberto. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas FisicoquĂmicas y Naturales. Instituto de Investigaciones en TecnologĂas EnergĂ©ticas y Materiales Avanzados. - Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto de Investigaciones en TecnologĂas EnergĂ©ticas y Materiales Avanzados; ArgentinaFil: Gervaldo, Miguel Andres. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas FisicoquĂmicas y Naturales. Instituto de Investigaciones en TecnologĂas EnergĂ©ticas y Materiales Avanzados. - Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto de Investigaciones en TecnologĂas EnergĂ©ticas y Materiales Avanzados; ArgentinaFil: Durantini, Andres MatĂas. Universidad Nacional de RĂo Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; ArgentinaFil: Durantini, Edgardo NĂ©stor. Universidad Nacional de RĂo Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; ArgentinaFil: Durantini, Javier Esteban. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas FisicoquĂmicas y Naturales. Instituto de Investigaciones en TecnologĂas EnergĂ©ticas y Materiales Avanzados. - Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto de Investigaciones en TecnologĂas EnergĂ©ticas y Materiales Avanzados; ArgentinaFil: Heredia, Daniel Alejandro. Universidad Nacional de RĂo Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentin
Multidifferential study of identified charged hadron distributions in -tagged jets in proton-proton collisions at 13 TeV
Jet fragmentation functions are measured for the first time in proton-proton
collisions for charged pions, kaons, and protons within jets recoiling against
a boson. The charged-hadron distributions are studied longitudinally and
transversely to the jet direction for jets with transverse momentum 20 GeV and in the pseudorapidity range . The
data sample was collected with the LHCb experiment at a center-of-mass energy
of 13 TeV, corresponding to an integrated luminosity of 1.64 fb. Triple
differential distributions as a function of the hadron longitudinal momentum
fraction, hadron transverse momentum, and jet transverse momentum are also
measured for the first time. This helps constrain transverse-momentum-dependent
fragmentation functions. Differences in the shapes and magnitudes of the
measured distributions for the different hadron species provide insights into
the hadronization process for jets predominantly initiated by light quarks.Comment: All figures and tables, along with machine-readable versions and any
supplementary material and additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-013.html (LHCb
public pages
Study of the decay
The decay is studied
in proton-proton collisions at a center-of-mass energy of TeV
using data corresponding to an integrated luminosity of 5
collected by the LHCb experiment. In the system, the
state observed at the BaBar and Belle experiments is
resolved into two narrower states, and ,
whose masses and widths are measured to be where the first uncertainties are statistical and the second
systematic. The results are consistent with a previous LHCb measurement using a
prompt sample. Evidence of a new
state is found with a local significance of , whose mass and width
are measured to be and , respectively. In addition, evidence of a new decay mode
is found with a significance of
. The relative branching fraction of with respect to the
decay is measured to be , where the first
uncertainty is statistical, the second systematic and the third originates from
the branching fractions of charm hadron decays.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-028.html (LHCb
public pages
Measurement of the ratios of branching fractions and
The ratios of branching fractions
and are measured, assuming isospin symmetry, using a
sample of proton-proton collision data corresponding to 3.0 fb of
integrated luminosity recorded by the LHCb experiment during 2011 and 2012. The
tau lepton is identified in the decay mode
. The measured values are
and
, where the first uncertainty is
statistical and the second is systematic. The correlation between these
measurements is . Results are consistent with the current average
of these quantities and are at a combined 1.9 standard deviations from the
predictions based on lepton flavor universality in the Standard Model.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-039.html (LHCb
public pages
Measurement of the B0sâÎŒ+ÎŒâ Branching Fraction and Effective Lifetime and Search for B0âÎŒ+ÎŒâ Decays
A search for the rare decays Bs0âÎŒ+ÎŒ- and B0âÎŒ+ÎŒ- is performed at the LHCb experiment using data collected in pp collisions corresponding to a total integrated luminosity of 4.4ââfb-1. An excess of Bs0âÎŒ+ÎŒ- decays is observed with a significance of 7.8 standard deviations, representing the first observation of this decay in a single experiment. The branching fraction is measured to be B(Bs0âÎŒ+ÎŒ-)=(3.0±0.6-0.2+0.3)Ă10-9, where the first uncertainty is statistical and the second systematic. The first measurement of the Bs0âÎŒ+ÎŒ- effective lifetime, Ï(Bs0âÎŒ+ÎŒ-)=2.04±0.44±0.05ââps, is reported. No significant excess of B0âÎŒ+ÎŒ- decays is found, and a 95% confidence level upper limit, B(B0âÎŒ+ÎŒ-)<3.4Ă10-10, is determined. All results are in agreement with the standard model expectations.A search for the rare decays and is performed at the LHCb experiment using data collected in collisions corresponding to a total integrated luminosity of 4.4 fb. An excess of decays is observed with a significance of 7.8 standard deviations, representing the first observation of this decay in a single experiment. The branching fraction is measured to be , where the first uncertainty is statistical and the second systematic. The first measurement of the effective lifetime, ps, is reported. No significant excess of decays is found and a 95 % confidence level upper limit, , is determined. All results are in agreement with the Standard Model expectations
Functionalized Magnetic Nanoparticles with BODIPYs for Bioimaging and Antimicrobial Therapy Applications
The antimicrobial capability and recyclability of two conjugates that combines the versatility of iron oxide magnetic nanoparticles (MNPs) with the high photosensitizing proficiency of boron-dipyrromethene (BODIPY) dyes are assessed. By a relatively simple synthetic pathway, two conjugates were obtained. The first one, MNP-B1, contains a highly fluorescent dye for bioimaging and suitable inactivating properties. The other one, MNP-B2, is optimized to improve the production of cytotoxic reactive oxygen species (ROS) by incorporating heavy atoms in the BODIPY core. In vitro experiments in bacterial cell suspensions and at the single bacterium level reveal that both conjugates can inactivate either Gram-positive (methicillin-resistant Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria. By means of fluorescence microscopy, not only cellular uptake of the conjugates but also recyclability and sustained performance over the cycles of photodynamic inactivation (PDI) are demonstrated. This is the first time that MNPs functionalized with BODIPY dyes are utilized to obtain fluorescent images of bacterial cells and photoinactivate pathogens.Fil: Scanone, Ana Coral. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y TecnologĂa de Materiales. Universidad Nacional de Mar del Plata. Facultad de IngenierĂa. Instituto de Investigaciones en Ciencia y TecnologĂa de Materiales; Argentina. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas FisicoquĂmicas y Naturales. Departamento de QuĂmica; ArgentinaFil: Santamarina, Sofia Carla. Universidad Nacional de RĂo Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas FisicoquĂmicas y Naturales. Departamento de QuĂmica; ArgentinaFil: Heredia, Daniel Alejandro. Universidad Nacional de RĂo Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas FisicoquĂmicas y Naturales. Departamento de QuĂmica; ArgentinaFil: Durantini, Edgardo NĂ©stor. Universidad Nacional de RĂo Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas FisicoquĂmicas y Naturales. Departamento de QuĂmica; ArgentinaFil: Durantini, Andres MatĂas. Universidad Nacional de RĂo Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - CĂłrdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina. Universidad Nacional de RĂo Cuarto. Facultad de Ciencias Exactas FisicoquĂmicas y Naturales. Departamento de QuĂmica; Argentin
Search for the decays and
A search for the rare decays and is performed using protonproton collision data collected with the LHCb detector. The data sample corresponds to an integrated luminosity of 3fb collected in 2011 and 2012. The leptons are reconstructed through the decay . Assuming no contribution from decays, an upper limit is set on the branching fraction at 95% confidence level. If instead no contribution from decays is assumed, the limit is at 95% confidence level. These results correspond to the first direct limit on and the world's best limit on .A search for the rare decays Bs0âÏ+Ï- and B0âÏ+Ï- is performed using protonâproton collision data collected with the LHCb detector. The data sample corresponds to an integrated luminosity of 3ââfb-1 collected in 2011 and 2012. The Ï leptons are reconstructed through the decay Ï-âÏ-Ï+Ï-ÎœÏ. Assuming no contribution from B0âÏ+Ï- decays, an upper limit is set on the branching fraction B(Bs0âÏ+Ï-)<6.8Ă10-3 at the 95% confidence level. If instead no contribution from Bs0âÏ+Ï- decays is assumed, the limit is B(B0âÏ+Ï-)<2.1Ă10-3 at the 95% confidence level. These results correspond to the first direct limit on B(Bs0âÏ+Ï-) and the worldâs best limit on B(B0âÏ+Ï-).A search for the rare decays and is performed using proton--proton collision data collected with the LHCb detector. The data sample corresponds to an integrated luminosity of 3fb collected in 2011 and 2012. The leptons are reconstructed through the decay . Assuming no contribution from decays, an upper limit is set on the branching fraction at 95% confidence level. If instead no contribution from decays is assumed, the limit is at 95% confidence level. These results correspond to the first direct limit on and the world's best limit on
Observation of five new narrow states decaying to
The mass spectrum is studied with a sample of collision data corresponding to an integrated luminosity of 3.3 fb, collected by the LHCb experiment. The is reconstructed in the decay mode . Five new, narrow excited states are observed: the , , , , and . Measurements of their masses and widths are reported.The Îc+K- mass spectrum is studied with a sample of pp collision data corresponding to an integrated luminosity of 3.3ââfb-1, collected by the LHCb experiment. The Îc+ is reconstructed in the decay mode pK-Ï+. Five new, narrow excited Ωc0 states are observed: the Ωc(3000)0, Ωc(3050)0, Ωc(3066)0, Ωc(3090)0, and Ωc(3119)0. Measurements of their masses and widths are reported.The mass spectrum is studied with a sample of collision data corresponding to an integrated luminosity of 3.3 fb, collected by the LHCb experiment. The is reconstructed in the decay mode . Five new, narrow excited states are observed: the , , , , and . Measurements of their masses and widths are reported
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