MFGLib: A Library for Mean-Field Games

Mean-field games (MFGs) are limiting models to approximate $N$-player games, with a number of applications. Despite the ever-growing numerical literature on computation of MFGs, there is no library that allows researchers and practitioners to easily create and solve their own MFG problems. The purpose of this document is to introduce MFGLib, an open-source Python library for solving general MFGs with a user-friendly and customizable interface. It serves as a handy tool for creating and analyzing generic MFG environments, along with embedded auto-tuners for all implemented algorithms. The package is distributed under the MIT license and the source code and documentation can be found at https://github.com/radar-research-lab/MFGLib/

Cardiac resynchronization therapy and its effects in patients with type 2 DIAbetes mellitus OPTimized in automatic vs. echo guided approach. Data from the DIA-OPTA investigators

Objectives: To evaluate the effects of cardiac resynchronization therapy (CRTd) in patients with type 2 diabetes mellitus (T2DM) optimized via automatic vs. echocardiography-guided approach. Background: The suboptimal atrio-ventricular (AV) and inter-ventricular (VV) delays optimization reduces CRTd response. Therefore, we hypothesized that automatic CRTd optimization might improve clinical outcomes in T2DM patients. Methods: We designed a prospective, multicenter study to recruit, from October 2016 to June 2019, 191 consecutive failing heart patients with T2DM, and candidate to receive a CRTd. Study outcomes were CRTd responders rate, hospitalizations for heart failure (HF) worsening, cardiac deaths and all cause of deaths in T2DM patients treated with CRTd and randomly optimized via automatic (n 93) vs. echocardiography-guided (n 98) approach at 12 months of follow-up. Results: We had a significant difference in the rate of CRTd responders (68 (73.1%) vs. 58 (59.2%), p 0.038), and hospitalizations for HF worsening (12 (16.1%) vs. 22 (22.4%), p 0.030) in automatic vs. echocardiography-guided group of patients. At multivariate Cox regression analysis, the automatic guided approach (3.636 [1.271–10.399], CI 95%, p 0.016) and baseline highest values of atrium pressure (automatic SonR values, 2.863 [1.537–6.231], CI 95%, p 0.006) predicted rate of CRTd responders. In automatic group, we had significant difference in SonR values comparing the rate of CRTd responders vs. non responders (1.24 ± 0.72 g vs. 0.58 ± 0.46 g (follow-up), p 0.001), the rate of hospitalizations for HF worsening events (0.48 ± 0.29 g vs. 1.18 ± 0.43 g, p 0.001), and the rate of cardiac deaths (1.13 ± 0.72 g vs. 0.65 ± 0.69 g, p 0.047). Conclusions: Automatic optimization increased CRTd responders rate, and reduced hospitalizations for HF worsening. Intriguingly, automatic CRTd and highest baseline values of SonR could be predictive of CRTd responders. Notably, there was a significant difference in SonR values for CRTd responders vs. non responders, and about hospitalizations for HF worsening and cardiac deaths. Clinical trial ClinicalTrials.gov Identifier NCT04547244. © 2020, The Author(s)

HmtDB, a Human Mitochondrial Genomic Resource Based on Variability Studies Supporting Population Genetics and Biomedical Research

BACKGROUND: Population genetics studies based on the analysis of mtDNA and mitochondrial disease studies have produced a huge quantity of sequence data and related information. These data are at present worldwide distributed in differently organised databases and web sites not well integrated among them. Moreover it is not generally possible for the user to submit and contemporarily analyse its own data comparing them with the content of a given database, both for population genetics and mitochondrial disease data. RESULTS: HmtDB is a well-integrated web-based human mitochondrial bioinformatic resource aimed at supporting population genetics and mitochondrial disease studies, thanks to a new approach based on site-specific nucleotide and aminoacid variability estimation. HmtDB consists of a database of Human Mitochondrial Genomes, annotated with population data, and a set of bioinformatic tools, able to produce site-specific variability data and to automatically characterize newly sequenced human mitochondrial genomes. A query system for the retrieval of genomes and a web submission tool for the annotation of new genomes have been designed and will soon be implemented. The first release contains 1255 fully annotated human mitochondrial genomes. Nucleotide site-specific variability data and multialigned genomes can be downloaded. Intra-human and inter-species aminoacid variability data estimated on the 13 coding for proteins genes of the 1255 human genomes and 60 mammalian species are also available. HmtDB is freely available, upon registration, at . CONCLUSION: The HmtDB project will contribute towards completing and/or refining haplogroup classification and revealing the real pathogenic potential of mitochondrial mutations, on the basis of variability estimation

Longevity of Replaced ICD/CRT-D

Longevity of Replaced ICD/CRT-D Introduction The longevity of defibrillators (ICD) is extremely important from both a clinical and economic perspective. We studied the reasons for device replacement, the longevity of removed ICD, and the existence of possible factors associated with shorter service life. Methods and Results Consecutive patients who underwent ICD replacement from March 2013 to May 2015 in 36 Italian centers were included in this analysis. Data on replaced devices were collected. A total of 953 patients were included in this analysis. In 813 (85%) patients the reason for replacement was battery depletion, while 88 (9%) devices were removed for clinical reasons and the remaining 52 because of system failure (i.e., lead or ICD generator failure or a safety advisory indication). The median service life was 5.9 years (25th–75th percentile, 4.9–6.9) for single- and dual-chamber ICD and 4.9 years (25th–75th percentile, 4.0–5.7) for CRT-D. On multivariate analysis, the factors CRT-D device, SC/DC ICD generator from Biotronik, percentage of ventricular pacing, and the occurrence of a system failure were positively associated with a replacement procedure. By contrast, the device from Boston Scientific was an independent protective factor against replacement. Considerable differences were seen in battery duration in both ICD and CRT-D. Specifically, Biotronik devices showed the shortest longevity among ICD and Boston Scientific showed the longest longevity among CRT-D (log-rank test, P < 0.001 for pairwise comparisons). Conclusion Several factors were associated with shorter service life of ICD devices: CRT-D, occurrence of system failure and percentage of ventricular pacing. Our results confirmed significant differences among manufacturers

Angiotensin receptor/Neprilysin inhibitor effects in CRTd non-responders: From epigenetic to clinical beside

We evaluated whether Angiotensin receptor/Neprilysin inhibitors (ARNI) reduce heart failure (HF) hospitalizations and deaths in cardiac resynchronization therapy with defibrillator (CRTd) non-responders patients at 12 months of follow-up, modulating microRNAs (miRs) implied in adverse cardiac remodeling

Optical Fiber Links Used in VLBI Networks and Remote Clock Comparisons: the LIFT/MetGesp Project

The synchronization between atomic clocks plays an important part in both radio astronomical and geodetic Very Long Baseline Interferometry, as the clocks are responsible for providing time and frequency reference at radio stations. The availability of highly stable optical fiber links from a few radio observatories and their national metrological institutes has recently allowed the streaming of frequencies from optical clocks based on the Sr/Yb lattice technology (even two order of magnitudes more stable than H-maser clocks). We will present the current status of the Italian Link for Frequency and Time (LIFT) and the ongoing e orts to realize a geodetic experiment utilizing the radio stations in Medicina and Matera connected in common clock via the optical fiber link. We will then show the results from the latest VLBI clock timing experiments also making use of the LIFT link to compare atomic clocks of the three italian radio VLBI antennas (Mc, Sr and Nt) using the rms noise in the interferometric phase. VLBI clock timing proves more e ective than Global Navigation Satellite System and less expensive than Two-Way Satellite Frequency and Time Transfer in synchronizing remote clocks

A Coherent Optical Fiber Link for Very Long Baseline Interferometry

We realize a phase-stabilised optical fiber backbone that connects the Italian National Metrology Institute with two radio telescopes over a 600 km baseline. This allows referencing of Very Long Baseline Interferometry (VLBI) facilities with the best atomic frequency standards available today and the implementation of a common-clock architecture, which we are now using to assess VLBI ultimate performances

Comparing remote atomic clocks via VLBI networks and fiber optic links: the LIFT/MetGeSp perspective

Very Long Baseline Interferometry experiments require an extremely precise synchronization between the atomic clocks keeping the time and frequency standards at radiotelescope observatories. Recently the availability of fiber optic links from a few radio observatories and their national metrological institutes has made possible the streaming of extremely stable frequency standards via optical atomic clocks (even two order of magnitudes better than Rubidium or Hydrogen maser standards). Firstly, I will present the infrastructure of the Italian Link for Frequency and Time (LIFT) and results of the MetGesp project aimed at finally creating a common clock between two of the antennas of the VLBI Italian Network. Secondly, I will show the results of VLBI experiments in which the phase rms noise was used to accurately compare the synchronicity of atomic clocks located at a few EVN sites (Medicina, Noto, Yebes, Torun). VLBI clock timing proves a valid alternative to satellite-based techniques such as Global Navigation Satellite System or Two-Way Satellite Frequency and Time Transfer