Buenas prácticas ambientales para la gestión de residuos de papel

La guía proporciona indicaciones sobre la importancia de la recogida selectiva de los residuos de papel y cartón en la UPV así como consejos útiles y buenas prácticas para minimizar el residuo o el impacto ambiental de los mismosSansano Del Castillo, I. (2013). Buenas prácticas ambientales para la gestión de residuos de papel. http://hdl.handle.net/10251/33735

El proceso de implantación del Sistema de Gestión Ambiental en la Universidad Politécnica de Valencia

En este artículo se describe el proceso de implantación de un sistema de gestión ambiental, según los requisitos de la norma UNE-EN ISO 14001 y el Reglamento Europeo EMAS, en la Universidad Politécnica de Valencia. El docuento describe las 15 fases en las que se dividió el proceso de implantación y aporta indicaciones sobre las herramientas de difusión utilizadas para fomentar el conocimiento del sistema y de los impactos ambientales generados por la actividad de la universidad.Sansano Del Castillo, I.; Muñoz Sánchez, Á. (2009). El proceso de implantación del Sistema de Gestión Ambiental en la Universidad Politécnica de Valencia. http://hdl.handle.net/10251/6381

El sistema de gestión ambiental de la Universitat Politècnica de València

El documento describe las particularidades de un sistema de gestión ambiental según la norma ISO14001 y el Reglamento EMAS implantado en una universidad, en concreto en la Universitat Politècnica de ValènciaSansano Del Castillo, I.; Martí Barranco, C. (2019). El sistema de gestión ambiental de la Universitat Politècnica de València. http://hdl.handle.net/10251/12409

Dietary acrylamide: What happens during digestion

[EN] Acrylamide is a well-known potentially carcinogen compound formed during thermal processing as an intermediate of Maillard reactions. Three objectives were addressed: the impact of gastric digestion on acrylamide content of French Fries, chips, chicken nuggets, onions rings, breakfast cereals, biscuits, crackers, instant coffee and coffee substitute; the acrylamide content evolution during gastrointestinal digestion of French fries and chips; and the effectiveness of blanching and air-frying on acrylamide mitigation after gastrointestinal digestion. A significant increase (p-value < 0.05) in acrylamide content was observed for most of the products after gastric digestion (maximum registered for sweet biscuits, from 30 +/- 8 to 150 +/- 48 mu g/kg). However, at the end of the intestinal stage, acrylamide values were statistically similar (p-value = 0.132) for French fries and lower than the initial values (before digestion) in potato chips (p-value = 0.027). Finally, the low acrylamide content found in blanched and air-fried samples, remained still lower than for deep fried samples even after gastrointestinal digestion. (C) 2017 Elsevier Ltd. All rights reserved.The authors would like to thank the Universitat Politecnica de Valencia for the PhD scholarship given to Mariola Sansano Tomas.Sansano Tomás, M.; Heredia Gutiérrez, AB.; Peinado Pardo, I.; Andrés Grau, AM. (2017). Dietary acrylamide: What happens during digestion. Food Chemistry. 237:58-64. doi:10.1016/j.foodchem.2017.05.104S586423

Digital Quantification of Tumor Cellularity as a Novel Prognostic Feature of Non–Small Cell Lung Carcinoma

Cancer; Image analysis; Thoracic pathologyCàncer; Anàlisi d'imatges; Patologia toràcicaCáncer; Análisis de imágenes; Patología torácicaNon–small cell lung carcinoma is currently staged based on the size and involvement of other structures. Tumor size may be a surrogate measure of the total number of tumor cells. A recently revised reporting system for adenocarcinoma incorporates high-risk histologic patterns, which may have increased cellular density. Modern digital image analysis tools can be utilized to automate the quantification of cells. In this study, we tested the hypothesis that tumor cellularity can be used as a novel prognostic tool for lung cancer. Digital slides from The Cancer Genome Atlas lung adenocarcinoma (ADC) data set (n = 213) and lung squamous cell carcinoma (SCC) data set (n = 90) were obtained and analyzed using QuPath. The number of tumor cells was normalized with the surface area of the tumor to provide a measure of tumor cell density. Tumor cellularity was calculated by multiplying the size of the tumor with the cell density. Major histologic patterns and grade were compared with the tumor density of the lung ADC and lung SCC cases. The overall and progression-free survival were compared between groups of high and low tumor cellularity. High-grade histologic patterns in the ADC and SCC cases were associated with greater tumor densities compared with low-grade patterns. Cases with lower tumor cellularity had improved overall and progression-free survival compared with cases with higher cellularity. These results support tumor cellularity as a novel prognostic tool for non–small cell lung carcinoma that considers tumor stage and grade elements.Funding support is gratefully acknowledged from the Megan J. Davey Opportunity Fund used to support a workstation to facilitate the computational analysis in this study and travel costs to present an earlier version of this content at the United States & Canadian Academy of Pathology 111th Annual Meeting (2022)

La universidad y la gestión de residuos: retos y oportunidades

En el artículo se trata la problemática de la gestión de los residuos en instituciones de enseñanza superior tomando como ejemplo el caso de la Universidad Politécnica de Valencia. Se hace hincapié en la problemática de la gestión derivada de las características propias de una universidad, pero también se presta especial atención a las oportunidades que presenta de cara al impacto social y medioambiental de la universidadSalinas González, R.; Sansano Del Castillo, I.; Muñoz Sánchez, Á. (2008). La universidad y la gestión de residuos: retos y oportunidades. I Simposio Iberoamericano de Ingeniería de Residuos. http://hdl.handle.net/10251/806

La implantación de un sistema de gestión ambiental en una universidad como herramienta de formación

El artículo expone el impacto que tiene sobre la formación y sensibilización ambiental de los alumnos universitarios la implantación de un sistema de gestión ambiental en la institución. Se toma como ejemplo el caso de la Universidad Politécnica de Valencia y se analizan las posibilidades de acción relacionadas con el currículo del alumno y las posibilidades de gestión de actividades extracurriculares.Salinas González, R.; Sansano Del Castillo, I.; Muñoz Sánchez, Á. (2009). La implantación de un sistema de gestión ambiental en una universidad como herramienta de formación. IV Jornadas de Educación Ambiental de la Comunitat Valenciana. http://hdl.handle.net/10251/806

Reliability of histopathologic diagnosis of fibrotic interstitial lung disease: an international collaborative standardization project

Malaltia pulmonar intersticial; Fibrosi pulmonar; Pneumònia intersticial habitualEnfermedad pulmonar intersticial; Fibrosis pulmonar; Neumonía intersticial habitualInterstitial lung disease; Pulmonary fibrosis; Usual interstitial pneumoniaBackground Current interstitial lung disease (ILD) diagnostic guidelines assess criteria across clinical, radiologic and pathologic domains. Significant interobserver variation in histopathologic evaluation has previously been shown but the specific source of these discrepancies is poorly documented. We sought to document specific areas of difficulty and develop improved criteria that would reduce overall interobserver variation. Methods Using an internet-based approach, we reviewed selected images of specific diagnostic features of ILD histopathology and whole slide images of fibrotic ILD. After an initial round of review, we confirmed the presence of interobserver variation among our group. We then developed refined criteria and reviewed a second set of cases. Results The initial round reproduced the existing literature on interobserver variation in diagnosis of ILD. Cases which were pre-selected as inconsistent with usual interstitial pneumonia/idiopathic pulmonary fibrosis (UIP/IPF) were confirmed as such by multi-observer review. Cases which were thought to be in the spectrum of chronic fibrotic ILD for which UIP/IPF were in the differential showed marked variation in nearly all aspects of ILD evaluation including extent of inflammation and extent and pattern of fibrosis. A proposed set of more explicit criteria had only modest effects on this outcome. While we were only modestly successful in reducing interobserver variation, we did identify specific reasons that current histopathologic criteria of fibrotic ILD are not well defined in practice. Conclusions Any additional classification scheme must address interobserver variation in histopathologic diagnosis of fibrotic ILD order to remain clinically relevant. Improvements to tissue-based diagnostics may require substantial resources such as larger datasets or novel technologies to improve reproducibility. Benchmarks should be established for expected outcomes among clinically defined subgroups as a quality metric.This research did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sectors

Validation of Cell-Free DNA Collection Tubes for Determination of EGFR Mutation Status in Liquid Biopsy from NSCLC Patients

Altres ajuts: Roche Farma S.A., Spain.Precision medicine has revolutionized the understanding and treatment of cancer by identifying subsets of patients who are amenable to specific treatments according to their molecular characteristics, as exemplified by epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC). Although tissue biopsy is the gold standard for determining molecular alterations in tumors, its limitations have prompted the development of new techniques for studying tumor biomarkers in liquid biopsies, such as mutation analysis in cell-free DNA (cfDNA). cfDNA analysis can accurately determine tumor progression and prognosis and more effectively identify appropriate targeted therapies. However, cfDNA is vulnerable, particularly during plasma sample shipping. We compared the cell- and DNA-stabilizing properties of cell-free DNA blood collection tubes (BCTs) with those of the traditional shipping method (frozen plasma) for EGFR mutation testing using the cobas ® EGFR Mutation Test v2 in a prospective cohort of 49 patients from three different Spanish hospitals. In total, 98 NSCLC samples, two from each patient, were studied; five of the 49 cases were considered invalid by cobas ® with one of the two shipping methods analyzed. After excluding these samples, we analyzed 88 samples from 44 patients. Considering the current methodology (frozen plasma) for sending samples as the gold standard, we evaluated the sensitivity and specificity of cfDNA BCT shipment. The global agreement between the two methods was 95.4%, with 100% sensitivity and 94.6% specificity for the cfDNA BCTs. cfDNA BCTs had a positive predictive value of 81.8% and negative predictive value of 100%. cfDNA BCTs have the same sensitivity for EGFR mutation analysis in liquid biopsy as the current methodology and very high specificity. They also have some additional advantages in terms of collection and further shipment. Therefore, cfDNA BCTs can be perfectly incorporated into the routine practice for EGFR mutation determination. Roche Farma S.A., Spain. The online version of this article (10.1007/s40487-019-00099-9) contains supplementary material, which is available to authorized users

Declaración Ambiental 2018

Se presentan los indicadores ambientales más relevantes para evaluar el comportamiento ambiental de la UPV a lo largo del año 2018Cerveró Albert, MC.; Estruch Fuster, AM.; Bellver Navarro, CG.; Sansano Del Castillo, I.; Martí Barranco, C. (2019). Declaración Ambiental 2018. http://hdl.handle.net/10251/12071