Vertical magnetic field gradient in the photospheric layers of sunspots

We investigate the vertical gradient of the magnetic field of sunspots in the photospheric layer. Independent observations were obtained with the SOT/SP onboard the Hinode spacecraft and with the TIP-2 mounted at the VTT. We apply state-of-the-art inversion techniques to both data sets to retrieve the magnetic field and the corresponding vertical gradient. In the sunspot penumbrae we detected patches of negative vertical gradients of the magnetic field strength, i.e.,the magnetic field strength decreases with optical depth in the photosphere. The negative gradient patches are located in the inner and partly in the middle penumbrae in both data sets. From the SOT/SP observations, we found that the negative gradient patches are restricted mainly to the deep photospheric layers and are concentrated near the edges of the penumbral filaments. MHD simulations also show negative gradients in the inner penumbrae, also at the locations of filaments. Both in the observations and simulation negative gradients of the magnetic field vs. optical depth dominate at some radial distances in the penumbra. The negative gradient with respect to optical depth in the inner penumbrae persists even after averaging in the azimuthal direction, both in the observations and, to a lesser extent, also in MHD simulations. We interpret the observed localized presence of the negative vertical gradient of the magnetic field strength in the observations as a consequence of stronger field from spines expanding with height and closing above the weaker field inter-spines. The presence of the negative gradients with respect to optical depth after azimuthal averaging can be explained by two different mechanisms: the high corrugation of equal optical depth surfaces and the cancellation of polarized signal due to the presence of unresolved opposite polarity patches in the deeper layers of the penumbra.Comment: 17 pages, 25 figures, accepted for publication in A&

Pre-flare activity and magnetic reconnection during the evolutionary stages of energy release in a solar eruptive flare

In this paper, we present a multi-wavelength analysis of an eruptive white-light M3.2 flare which occurred in active region NOAA 10486 on November 1, 2003. Excellent set of high resolution observations made by RHESSI and TRACE provide clear evidence of significant pre-flare activities for ~9 minutes in the form of an initiation phase observed at EUV/UV wavelengths followed by the X-ray precursor phase. During the initiation phase, we observed localized brightenings in the highly sheared core region close to the filament and interactions among short EUV loops overlying the filament which led to the opening of magnetic field lines. The X-ray precursor phase is manifested in RHESSI measurements below ~30 keV and coincided with the beginning of flux emergence at the flaring location along with early signatures of the eruption. From the RHESSI observations, we conclude that both plasma heating and electron acceleration occurred during the precursor phase. The main flare is consistent with the standard flare model. However, after the impulsive phase, intense HXR looptop source was observed without significant footpoint emission. More intriguingly, for a brief period the looptop source exhibited strong HXR emission with energies up to 100 keV and significant non-thermal characteristics. The present study indicates a causal relation between the activities in the preflare and main flare. We also conclude that pre-flare activities, occurred in the form of subtle magnetic reorganization along with localized magnetic reconnection, played a crucial role in destabilizing the active region filament leading to solar eruptive flare and associated large-scale phenomena.Comment: 31 pages, 13 figures; Accepted in The Astrophysical Journa

Effect of Polarimetric Noise on the Estimation of Twist and Magnetic Energy of Force-Free Fields

The force-free parameter $\alpha$, also known as helicity parameter or twist parameter, bears the same sign as the magnetic helicity under some restrictive conditions. The single global value of $\alpha$ for a whole active region gives the degree of twist per unit axial length. We investigate the effect of polarimetric noise on the calculation of global $\alpha$ value and magnetic energy of an analytical bipole. The analytical bipole has been generated using the force-free field approximation with a known value of constant $\alpha$ and magnetic energy. The magnetic parameters obtained from the analytical bipole are used to generate Stokes profiles from the Unno-Rachkovsky solutions for polarized radiative transfer equations. Then we add random noise of the order of 10$^{-3}$ of the continuum intensity (I$_{c}$) in these profiles to simulate the real profiles obtained by modern spectropolarimeters like Hinode (SOT/SP), SVM (USO), ASP, DLSP, POLIS, SOLIS etc. These noisy profiles are then inverted using a Milne-Eddington inversion code to retrieve the magnetic parameters. Hundred realizations of this process of adding random noise and polarimetric inversion is repeated to study the distribution of error in global $\alpha$ and magnetic energy values. The results show that : (1). the sign of $\alpha$ is not influenced by polarimetric noise and very accurate values of global twist can be calculated, and (2). accurate estimation of magnetic energy with uncertainty as low as 0.5% is possible under the force-free condition.Comment: 33 pages, 6 figures, 1 table; Accepted for publication in the Ap

TH3.2: Livelihood Aspirations and Realities of Young People in a Myanmar Fishing Community

Youth livelihoods in food-systems are increasingly the focus of development institutions, drawing attention to how the livelihood aspirations of young people shape their engagements with food-systems. This study sought to understand the livelihood aspirations of young people from a historically poor and marginalized fishing community in the Ayeyarwady Delta of Myanmar, and how these aspirations shaped livelihood realities. Data collection was through focus group discussions (seven FGDs) and semi-structured interviews with youth and other household members, from fisher households and others in the village (73 interviews, including 15 female youth 13 male youth from fisher households). For these youth, the political and economic transitions experienced by Myanmar in the last decade offered aspirations for new desired futures, beyond those associated with poverty and marginalization. However, for many of these young people, due to the realities of their socio-economic and gendered positioning, aspiring did not involve a straightforward navigation towards futures that were strictly defined. Instead, their aspirations remained broad and vague, and concretized, on strongly gendered terms, based on opportunities encountered in the present. Therefore, while few of their livelihood realities aligned with these desired futures, in a changing environment considered synonymous with progress, these engagements were marked by a sense of temporariness, and a looking to the future for better opportunities to emerge. The study contributes to the growing recognition that the livelihood engagements of many young people and their intersections with food-systems are not marked by complete arrivals or departures, but by a moving in and out of multiple geographies and sectors

A policymaker’s guide to understanding youth livelihood aspirations in Myanmar

The International Water Management Institute (IWMI) and WorldFish conducted a study with young people from a fishing community in the Ayeyarwady Delta of Myanmar. The study sought to understand the livelihood aspirations of these young people and how they were connected to eventual livelihood realities

Heat Shock Protein 90 Inhibitors Prevent LPS-Induced Endothelial Barrier Dysfunction by Disrupting Rhoa Signaling

Permeability of the endothelial monolayer is increased when exposed to the bacterial endotoxin LPS. Our previous studies have shown that heat shock protein (Hsp) 90 inhibitors protect and restore LPS-mediated hyperpermeability in bovine pulmonary arterial endothelial cells. In this study, we assessed the effect of Hsp90 inhibition against LPS-mediated hyperpermeability in cultured human lung microvascular endothelial cells (HLMVECs) and delineated the underlying molecular mechanisms. We demonstrate that Hsp90 inhibition is critical in the early phase, to prevent LPS-mediated hyperpermeability, and also in the later phase, to restore LPS-mediated hyperpermeability in HLMVECs. Because RhoA is a well known mediator of endothelial hyperpermeability, we investigated the effect of Hsp90 inhibition on LPS-mediated RhoA signaling. RhoA nitration and activity were increased by LPS in HLMVECs and suppressed when pretreated with the Hsp90 inhibitor, 17-allylamino-17 demethoxy-geldanamycin (17-AAG). In addition, inhibition of Rho kinase, a downstream effector of RhoA, protected HLMVECs from LPS-mediated hyperpermeability and abolished LPS-induced myosin light chain (MLC) phosphorylation, a target of Rho kinase. In agreement with these findings, 17-AAG or dominant-negative RhoA attenuated LPS-induced MLC phosphorylation. MLC phosphorylation induced by constitutively active RhoA was also suppressed by 17-AAG, suggesting a role for Hsp90 downstream of RhoA. Inhibition of Src family kinases also suppressed RhoA activity and MLC phosphorylation. Together, these data indicate that Hsp90 inhibition prevents and repairs LPS-induced lung endothelial barrier dysfunction by suppressing Src-mediated RhoA activity and signaling

Left ventricular remodeling and hypertrophy in patients with aortic stenosis:insights from cardiovascular magnetic resonance

<p>Abstract</p> <p>Background</p> <p>Cardiovascular magnetic resonance (CMR) is the gold standard non-invasive method for determining left ventricular (LV) mass and volume but has not been used previously to characterise the LV remodeling response in aortic stenosis. We sought to investigate the degree and patterns of hypertrophy in aortic stenosis using CMR.</p> <p>Methods</p> <p>Patients with moderate or severe aortic stenosis, normal coronary arteries and no other significant valve lesions or cardiomyopathy were scanned by CMR with valve severity assessed by planimetry and velocity mapping. The extent and patterns of hypertrophy were investigated using measurements of the LV mass index, indexed LV volumes and the LV mass/volume ratio. Asymmetric forms of remodeling and hypertrophy were defined by a regional wall thickening <b>≥</b>13 mm and >1.5-fold the thickness of the opposing myocardial segment.</p> <p>Results</p> <p>Ninety-one patients (61±21 years; 57 male) with aortic stenosis (aortic valve area 0.93±0.32cm2) were recruited. The severity of aortic stenosis was unrelated to the degree (r²=0.012, P=0.43) and pattern (P=0.22) of hypertrophy. By univariate analysis, only male sex demonstrated an association with LV mass index (P=0.02). Six patterns of LV adaption were observed: normal ventricular geometry (n=11), concentric remodeling (n=11), asymmetric remodeling (n=11), concentric hypertrophy (n=34), asymmetric hypertrophy (n=14) and LV decompensation (n=10). Asymmetric patterns displayed considerable overlap in appearances (wall thickness 17±2mm) with hypertrophic cardiomyopathy.</p> <p>Conclusions</p> <p>We have demonstrated that in patients with moderate and severe aortic stenosis, the pattern of LV adaption and degree of hypertrophy do not closely correlate with the severity of valve narrowing and that asymmetric patterns of wall thickening are common.</p> <p>Trial registration</p> <p>ClinicalTrials.gov Reference Number: NCT00930735</p