Histological and Physico-chemical Evaluation of Zanthoxylum nitidum Stem Bark

Zanthoxylum nitidum (Roxb.) DC (Rutaceae), called Tez-mui in Assamese, is a large prickly shrub, and its stem bark is ethnomedicinally prescribed in North-East India for treatment of various disease conditions. Scientific parameters are not yet available to identify the exact plant material and to ascertain its quality and purity. The present investigation was therefore undertaken to determine the requisite histological and physico-chemical standards for evaluating the plant material. These studies provided referential pharmaco-botanical information for correct identification and standardization of this plant material. These information will also be helpful to differentiate Z. nitidum from the closely related other species of Zanthoxylum

DC electrical properties and non–adiabatic small polaron hopping in V2O5–CdO–ZnO glass nanocomposites

Semiconducting transition metal oxide (TMO) doped glass nanocomposites xV2O5–(1–x) (0.05CdO–0.95ZnO), x=0.3, 0.5, 0.7 and 0.9 have been prepared by melt quenching method. DC electrical conductivity of as prepared glass nanocomposites is are investigated over a wide temperature range. Formation of small polarons has been confirmed from dc electrical conductivity experimental data, whereas conductivity is due to mainly polaron hopping from V+4 to V+5 valence state in these glassy systems. Temperature dependent conductivity data have been analyzed using the small polaron hopping (SPH) model. Low, high temperature activation energy, optical phonon frequency and Debye’s temperature have been determined. Conductivity data have been analyzed in view of Mott’s variable range hopping (VRH) models and Greaves VRH models; the density of states at the Fermi level has been evaluated. Various polaron hopping parameters such as polaron radius, polaron binding energy, polaron band width and polaron coupling constant (γP) have been estimated. It has been ascertained by these estimated quantities and different approaches that the nature of hopping conduction is non–adiabatic variable range hopping of small polarons. The evaluated values of hopping carrier mobility (μ) and hopping carrier concentration (NC) are found to depend on composition and temperature

Preclinical evaluation of antihyperglycemic activity of Clerodendron infortunatum leaf against streptozotocin-induced diabetic rats

© The Author(s) 2011. This article is published with open access at Springerlink.com Introduction: Clerodendron infortunatum Linn. (Verbenaceae), commonly known as Bhant in Hindi, is a small shrub occurring throughout the plains of India, which is traditionally used for several medicinal purposes. The aim of the present stud

Comprehensive studies on the electrical transport of some chalcogenide semiconductors: frequency- and temperature-dependent AC conductivity

The AC conductivity of chalcogenide semiconductors doped with Ag2S was extensively studied, not only for applications in devices but also for academic interests. X-ray diffraction studies reveal the presence of GeS, Ag2S, Se5.1S1.9, Se2.57S5.43, Ag2Se, S3Se5, Se4.7S3.3, and Ag8S nanocrystallites. The characteristic vibration that appeared in the range 500–600 cm−1 is due to the Ag–S bond, and the vibrations at 3,700 and 1600 cm−1 can be assigned as the bending and stretching vibrations of the O–H bond, which may be formed due to the adsorption of H2O molecules on the Ag2S surface. DC electrical conductivity can be increased by optical phonon frequency, which may be involved in the enhancement of structural vibrations. At low temperatures, the “density of states” increases from 3.337 × 1019 to 2.396 × 1021 eV−1 cm−3, and at high temperatures, it enhances from 3.417 × 1028 to 1.1356 × 1031 eV– 1 cm−3. The correlated barrier hopping model explores the maximum barrier height for composition, x = 0.1 as 0.0292 eV. The modified non-overlapping small polaron tunnelling model reveals the polaron transfer activation energy for x = 0.2 as 0.09110 eV. The independence of the electrical relaxation process of the system on temperature and its dependence on composition were exhibited by the scaling of the conductivity spectra

Evaluation of Antihyperglycemic Activity of Citrus limetta Fruit Peel in Streptozotocin-Induced Diabetic Rats

The present paper aims to evaluate antihyperglycemic activity of methanol extract of Citrus limetta fruit peel (MECL) in streptozotocin-induced (STZ; 65 mg/kg b.w.) diabetic rats. Three days after STZ induction, diabetic rats received MECL orally at 200 and 400 mg kg−1 body weight daily for 15 days. Glibenclamide (0.5 mg kg−1 p. o.) was used as reference drug. Blood glucose levels were measured on 0th, 4th, 8th, and 15th days of study. Serum biochemical parameters namely, SGOT, SGPT and ALP were estimated. The TBARS and GSH levels of pancreas, kidney, and liver were determined. MECL significantly (P < 0.001) and dose dependently normalized blood glucose levels and serum biochemical parameters, decreased lipid peroxidation, and recovered GSH as compared to those of STZ control. The present paper infers that in STZ-induced diabetic Wistar rats, C. limetta fruit peel demonstrated a potential antihyperglycemic effect which may be attributed to its antioxidant property

Antimicrobial Susceptibility Patterns of Salmonella enterica Serotype Typhi in Eastern Nepal

The aim of the present study was to evaluate antimicrobial susceptibility patterns with special reference to multidrug resistance, susceptibility to ciprofloxacin, and bacteriophage typing of Salmonella enterica serotype Typhi isolated from blood sent for culture in a tertiary-care teaching hospital in eastern Nepal during January 2000\u2013December 2004. In total, 132 strains of S. enterica Typhi, isolated from 2,568 blood culture samples collected from cases of suspected enteric fever, were tested for susceptibility to commonly-used antimicrobials by the disc-diffusion method. There were 35 multidrug-resistant strains. None of the isolates were resistant to ciprofloxacin.Of 52 isolates tested for minimum inhibitory concentration (MIC) of ciprofloxacin, 36 (69.23%) showed reduced susceptibility (MIC 650.25 mg/L). Of 112 strains tested for nalidixicacid susceptibility,86(76%) were resistant. Strains with reduced susceptibility to ciprofloxacin and resistance to nalidixic acid could be correlated. The commonest phage type was E1. Nalidixic acid susceptibility could be a useful screening test for the detection of decreased susceptibility of S. Typhi to ciprofloxacin, a drug which is commonly used even for minor ailments in this area

Challenges and Policy Implications for Low-Carbon Pathway for Kerala: An Integrated Assessment Modelling Approach

As India has embarked on the journey of fulfilling its net-zero emissions target by 2070, the states of India are steering up too to meet the target. The per capita emissions for Kerala are lower than the national average. The energy sector is the main contributor to GHG emissions in Kerala. A major share of 76 percent of electricity power is purchased from other states. When other states undergo an energy transition, the availability of imported electricity may be a challenge for Kerala. Hence, the State needs to harness its own potential for renewable energy sources and incorporate improved technologies leading to energy efficiencies in all sectors. Accordingly, this paper has undertaken integrated modelling (an approach with the primary objective of quantifying the gains and losses of low-carbon transitions and their financial implications). The integrated modelling approach involves soft linking of the macroeconomic top-down CGE model and bottom-up (Messageix) energy model. The integrated model is a recursive dynamic model with multiple periods of time. In this paper, we have undertaken a policy scenario in which (i) the imports of fossil-based electricity from other states of India are restricted to Kerala, (ii) 50 percent of the existing potential of renewable electricity by various modes is achieved in Kerala and the rest of India, and (iii) energy efficiency in all energy sectors is increased to the tune of 2.5 percent per annum along with 1 percent total productivity growth per annum in all sectors of the Kerala and India economies. Our results show that the reduced import of fossil fuel electricity without any policy intervention to strengthen the renewable energy sector would hamper growth. On the other hand, investment in renewable energy to facilitate a complete energy transition with self-reliance on energy for the state would expand the economy, increase the returns to the factors of production, and increase employment. The key message that comes out from our simulation is that the energy transition towards renewable energy will not take place without complementarity support polices towards this sector. Our observation is that energy transition may be a win‒win situation in the sense that growth and employment creation may be positive with suitable policy intervention. It must be mentioned that the paper focused only on the energy sector. The developed model may be used in the future to focus on the economic implications of other policies, such as carbon sequestration

Trichosanthes dioica root extract induces tumor proliferation and attenuation of antioxidant system in albino mice bearing Ehrlich ascites carcinoma

Trichosanthes dioica Roxb. (Cucurbitaceae), called pointed gourd in English, is a dioecious climber grown widely in the Indian subcontinent. The present study assessed the influence of treatment of hydroalcoholic extract of Trichosanthes dioica root (TDA) on Ehrlich ascites carcinoma (EAC) in Swiss albino mice with effects on antioxidant systems. Twenty-four hours after intraperitoneal inoculation of tumor (EAC) cells in mice, TDA was administered at 25 and 50 mg/kg for 8 consecutive days. On the 9th day, half of the mice were sacrificed for estimation of tumor proliferation, hematological, and hepatic antioxidative parameters. The rest were kept for assessment of survival parameters. TDA exhibited dose dependent and significant increase in tumor weight, tumor volume, packed cell volume and viable cells and reduced non-viable cells and life span of EAC bearing animals. Hematological parameters were significantly worsened in TDA-treated mice. TDA treatment significantly aggravated the hepatic antioxidative parameters. The present study demonstrated that T. dioica root possessed tumor promoting activity in EAC bearing albino mice, plausibly mediated by attenuation of endogenous antioxidant systems