Radiative and Collisional Jet Energy Loss in the Quark-Gluon Plasma at RHIC

We calculate and compare bremsstrahlung and collisional energy loss of hard partons traversing a quark-gluon plasma. Our treatment of both processes is complete at leading order in the coupling and accounts for the probabilistic nature of the jet energy loss. We find that the nuclear modification factor $R_{AA}$ for neutral $\pi^0$ production in heavy ion collisions is sensitive to the inclusion of collisional and radiative energy loss contributions while the averaged energy loss only slightly increases if collisional energy loss is included for parent parton energies $E\gg T$. These results are important for the understanding of jet quenching in Au+Au collisions at $200 {\rm AGeV}$ at RHIC. Comparison with data is performed applying the energy loss calculation to a relativistic ideal (3+1)-dimensional hydrodynamic description of the thermalized medium formed at RHIC.Comment: 4 pages, 3 figure

Sleep Status and the Risk Factor of Drowsy-Related Accidents in Commercial Motor Vehicle Drivers

Background and Objective The purpose of this study was to describe prevalence of sleep problems including obstructive sleep apnea (OSA), insomnia, and sleep insufficiency in commercial motor vehicle (CMV) drivers, and to quantify risk of drowsy-related accidents in CMV drivers. Methods CMV drivers were invited to participate in this study. Participants were asked to complete a questionnaire about sleep habits, sleep disorders, work environments, and experience of drowsy-related accidents. A home sleep test (Watch-PAT 200) was also undertaken to detect OSA. Results Among 110 participants, 89 with eligible data of questionnaires and home sleep tests were included in the analysis. 91.0% of participants had OSA with peripheral arterial tonometry respiratory distress index (pRDI) ≥ 5/h and 23.6% had moderate to severe OSA with pRDI ≥ 15/h. 55.1% perceived that their sleep is insufficient. 52.3% of participants experienced drowsy driving. Drowsy driving-related motor vehicle crashes (MVCs) and near miss MVCs were reported by 9.6% and 37.9% of participants, respectively. Multiple regression analysis showed that increased risk of drowsy driving was associated with perceived sleep insufficiency [odds ratio (OR) = 3.48, 95% confidence interval (CI) 1.26–9.64]. Increased risk of drowsy driving-related near miss MVC was associated with perceived sleep insufficiency (OR = 3.06, 95% CI 1.11–8.44) and continuous driving for more than 4 hours (OR = 3.10, 95% CI 1.00–9.58). Conclusions OSA and perceived sleep insufficiency are prevalent in CMV drivers. Perceived sleep insufficiency and longer continuous driving hours increased risk of drowsy-related accidents

Comparison of Jet Quenching Formalisms for a Quark-Gluon Plasma "Brick"

We review the currently available formalisms for radiative energy loss of a high-momentum parton in a dense strongly interacting medium. The underlying theoretical framework of the four commonly used formalisms is discussed and the differences and commonalities between the formalisms are highlighted. A quantitative comparison of the single gluon emission spectra as well as the energy loss distributions is given for a model system consisting of a uniform medium with a fixed length of L=2 fm and L=5 fm (the `Brick'). Sizable quantitative differences are found. The largest differences can be attributed to specific approximations that are made in the calculation of the radiation spectrum.Comment: 30 pages, 24 figures update version2: added curves with large x to Figure 14, Higher Twist curves to Figs 19, 20, plus some changes in the text (introduction/summary, discussion of Fig 14 and HT section

Hexosamine Biosynthetic Pathway-Derived O-GlcNAcylation Is Critical for RANKL-Mediated Osteoclast Differentiation

O-linked-N-acetylglucosaminylation (O-GlcNAcylation) performed by O-GlcNAc transferase (OGT) is a nutrient-responsive post-translational modification (PTM) via the hexosamine biosynthetic pathway (HBP). Various transcription factors (TFs) are O-GlcNAcylated, affecting their activities and significantly contributing to cellular processes ranging from survival to cellular differentiation. Given the pleiotropic functions of O-GlcNAc modification, it has been studied in various fields; however, the role of O-GlcNAcylation during osteoclast differentiation remains to be explored. Kinetic transcriptome analysis during receptor activator of nuclear factor-kappaB (NF-κB) ligand (RANKL)-mediated osteoclast differentiation revealed that the nexus of major nutrient metabolism, HBP was critical for this process. We observed that the critical genes related to HBP activation, including Nagk, Gfpt1, and Ogt, were upregulated, while the global O-GlcNAcylation was increased concomitantly during osteoclast differentiation. The O-GlcNAcylation inhibition by the small-molecule inhibitor OSMI-1 reduced osteoclast differentiation in vitro and in vivo by disrupting the translocation of NF-κB p65 and nuclear factor of activated T cells c1 (NFATc1) into the nucleus by controlling their PTM O-GlcNAcylation. Furthermore, OSMI-1 had a synergistic effect with bone target therapy on osteoclastogenesis. Lastly, knocking down Ogt with shRNA (shOgt) mimicked OSMI-1’s effect on osteoclastogenesis. Targeting O-GlcNAcylation during osteoclast differentiation may be a valuable therapeutic approach for osteoclast-activated bone diseases

α-Synuclein at the Presynaptic Axon Terminal as a Double-Edged Sword

α-synuclein (α-syn) is a presynaptic, lipid-binding protein strongly associated with the neuropathology observed in Parkinson’s disease (PD), dementia with Lewy bodies (DLB), and Alzheimer’s Disease (AD). In normal physiology, α-syn plays a pivotal role in facilitating endocytosis and exocytosis. Interestingly, mutations and modifications of precise α-syn domains interfere with α-syn oligomerization and nucleation that negatively affect presynaptic vesicular dynamics, protein expressions, and mitochondrial profiles. Furthermore, the integration of the α-syn oligomers into the presynaptic membrane results in pore formations, ion influx, and excitotoxicity. Targeted therapies against specific domains of α-syn, including the use of small organic molecules, monoclonal antibodies, and synthetic peptides, are being screened and developed. However, the prospect of an effective α-syn targeted therapy is still plagued by low permeability across the blood–brain barrier (BBB), and poor entry into the presynaptic axon terminals. The present review proposes a modification of current strategies, which includes the use of novel encapsulation technology, such as lipid nanoparticles, to bypass the BBB and deliver such agents into the brain

Imaging Kv1.3 Expressing Memory T Cells as a Marker of Immunotherapy Response

Immune checkpoint inhibitors have shown great promise, emerging as a new pillar of treatment for cancer; however, only a relatively small proportion of recipients show a durable response to treatment. Strategies that reliably differentiate durably-responding tumours from non-responsive tumours are a critical unmet need. Persistent and durable immunological responses are associated with the generation of memory T cells. Effector memory T cells associated with tumour response to immune therapies are characterized by substantial upregulation of the potassium channel Kv1.3 after repeated antigen stimulation. We have developed a new Kv1.3 targeting radiopharmaceutical, [18F]AlF-NOTA-KCNA3P, and evaluated whether it can reliably differentiate tumours successfully responding to immune checkpoint inhibitor (ICI) therapy targeting PD-1 alone or combined with CLTA4. In a syngeneic colon cancer model, we compared tumour retention of [18F]AlF-NOTA-KCNA3P with changes in the tumour immune microenvironment determined by flow cytometry. Imaging with [18F]AlF-NOTA-KCNA3P reliably differentiated tumours responding to ICI therapy from non-responding tumours and was associated with substantial tumour infiltration of T cells, especially Kv1.3-expressing CD8+ effector memory T cells

Extracting the jet transport coefficient from jet quenching in high-energy heavy-ion collisions

Within five different approaches to parton propagation and energy loss in dense matter, a phenomenological study of experimental data on suppression of large pT single inclusive hadrons in heavy-ion collisions at both RHIC and LHC was carried out. The evolution of bulk medium used in the study for parton propagation was given by 2+1D or 3+1D hydrodynamic models which are also constrained by experimental data on bulk hadron spectra. Values for the jet transport parameter ˆq at the center of the most central heavy-ion collisions are extracted or calculated within each model, with parameters for the medium properties that are constrained by experimental data on the hadron suppression factor RAA. For a quark with initial energy of 10 GeV we find that qˆ ≈ 1.2 ± 0.3 GeV2 /fm at an initial time τ0 = 0.6 fm/c in Au+Au collisions at √ s = 200 GeV/n and ˆq ≈ 1.9 ± 0.7 GeV2 /fm in Pb+Pb collisions at √ s = 2.76 TeV/n. Compared to earlier studies, these represent significant convergence on values of the extracted jet transport parameter, reflecting recent advances in theory and the availability of new experiment data from the LHC