Застосування КМСОНП в системі дистанційного навчання ATutor на основі модуля електронного журналу

Low vitamin D levels during pregnancy may have negative consequences for the health of both the mother and child. Cross-sectional studies in childbearing women suggest that vitamin D levels are low during pregnancy, but few studies have followed the same women during pregnancy and postpartum. The aims of this study were to longitudinally assess vitamin D status during pregnancy and postpartum and identify the factors associated with vitamin D status in pregnant women in northern Sweden. Between September 2006 and March 2009, 184 women were consecutively recruited at five antenatal primary care clinics. Blood was sampled, and dietary intake was estimated using a food frequency questionnaire with 66 food items/food aggregates and questions on the intake of vitamin supplements at gestational weeks 12, 21, and 35, as well as at 12 and 29 weeks after birth. Plasma 25(OH) vitamin D levels were analyzed using liquid chromatography tandem-mass spectrometry. At least one-third of the women had 25(OH) vitamin D levels <50 nmol/L on at least one sampling occasion. Plasma levels increased slightly over the gestation period and peaked in late pregnancy. The levels reverted to the baseline levels after birth. Multivariate analysis showed that gestational and postpartum week, season, dietary intake of vitamin D, and vitamin supplementation were significantly related to plasma levels. There was also an influence of season on the longitudinal concentration patterns. In conclusion, more than one-third of the women studied had low 25(OH) vitamin D levels, and gestational and postpartum week was related to 25(OH) vitamin D levels after adjustment for season and vitamin D intake

Lessons on Tumour Response: Imaging during Therapy with 177Lu-DOTA-octreotate. A Case Report on a Patient with a Large Volume of Poorly Differentiated Neuroendocrine Carcinoma

Favourable outcomes of peptide receptor radiotherapy (PRRT) of neuroendocrine tumours have been reported during the last years. Still, there are uncertainties on the radionuclides to be used, the treatment planning, and the indication in patients with a high proliferation rate

Chlamydia trachomatis antigens in enteroendocrine cells and macrophages of the small bowel in patients with severe irritable bowel syndrome

<p>Abstract</p> <p>Background</p> <p>Inflammation and immune activation have repeatedly been suggested as pathogentic factors in irritable bowel syndrome (IBS). The driving force for immune activation in IBS remains unknown. The aim of our study was to find out if the obligate intracellular pathogen <it>Chlamydia </it>could be involved in the pathogenesis of IBS.</p> <p>Methods</p> <p>We studied 65 patients (61 females) with IBS and 42 (29 females) healthy controls in which IBS had been excluded. Full thickness biopsies from the jejunum and mucosa biopsies from the duodenum and the jejunum were stained with a monoclonal antibody to <it>Chlamydia </it>lipopolysaccharide (LPS) and species-specific monoclonal antibodies to <it>C. trachomatis </it>and <it>C. pneumoniae</it>. We used polyclonal antibodies to chromogranin A, CD68, CD11c, and CD117 to identify enteroendocrine cells, macrophages, dendritic, and mast cells, respectively.</p> <p>Results</p> <p><it>Chlamydia </it>LPS was present in 89% of patients with IBS, but in only 14% of healthy controls (p < 0.001) and 79% of LPS-positive biopsies were also positive for <it>C. trachomatis </it>major outer membrane protein (MOMP). Staining for <it>C. pneumoniae </it>was negative in both patients and controls. <it>Chlamydia </it>LPS was detected in enteroendocrine cells of the mucosa in 90% of positive biopsies and in subepithelial macrophages in 69% of biopsies. Biopsies taken at different time points in 19 patients revealed persistence of <it>Chlamydia </it>LPS up to 11 years. The odds ratio for the association of <it>Chlamydia </it>LPS with presence of IBS (43.1; 95% CI: 13.2-140.7) is much higher than any previously described pathogenetic marker in IBS.</p> <p>Conclusions</p> <p>We found <it>C. trachomatis </it>antigens in enteroendocrine cells and macrophages in the small bowel mucosa of patients with IBS. Further studies are required to clarify if the presence of such antigens has a role in the pathogenesis of IBS.</p

Svenska hus av Helgo Zettervall

Hans Sandström är tillsammans med arkitektkollegorna Per-Anders Johansson och Arne Tollbom författare till bo­ken "Villor och boställen av Helgo Zettervall", som ut­gavs av Konsthögskolans Arkitekturskola 1994. Källor för den Zettervallintresserade läsaren är också "Något om mig sjelf", självbiografiska anteckningar utgivna av Chris­tian Callmer, Kungl biblioteket, 1981 och Helgo Zetter­valls eget arbete "Hufvud Conto, utförde arbeten av un­dertecknad", Konsthögskolans Arkitekturskola, 1983.

Byggnadsvård som internationellt samarbete : Riksantikvarieämbetet i Estland och Lettland

Riksantikvarieämbetet fick våren 1998 ett uppdrag av regeringen att genomföra restaurering av trebyggnader i Tallinn -Kadriorgs slott, svenska S:t Mikaelskyrkan och ett litet trähus i stadsdelen Kalamaja. I november 1999 fick RAÄ ett likartat uppdrag för tre byggnader i Lettland -de timrade herrgårdarna Ramava och Ungurmuiza och en synagoga från 1890-talet i staden Sabile. Finansieringen kom i båda fallen huvudsakligen från Sverige och regeringens östersjömiljard. Erfarenhetsutbyte, utbildning och information var viktiga inslag i samarbetet, som avslutades under våren 2002

Byggnadshyttan Mälsåker på nätet

Sommaren 1993 startade restaureringsarbeten på Mälsåkers slott, finansierade med arbetsmarknadsmedel och organiserade som en "byggnadshytta". Byggnadshyttan fick sitt namn därför att den ägnar sig åt såväl restaurering som kunskapsutveckling och utbildning. Förebilden finns vid de stora medeltida katedralbyggena och namnet betecknar både själva verkstadsbyggnaden (där framför allt stenhuggarna höll till) och gemenskapen (som består av människor)