Les métamorphoses de Sweeney

La légende de Sweeney, dont les premières traces apparaissent en Irlande dans des manuscrits du Moyen-âge, a frappé l’imagination de nombreux auteurs contemporains au rang desquels le prix Nobel Seamus Heaney. Ce « mystérieux roi poète métamorphosé en oiseau et condamné à la folie et à l’errance » (7), personnage à la fois tragique et grotesque a déployé ses ailes sur la littérature irlandaises de notre époque, pour inspirer chef d’œuvre après chef-d’œuvre. Dans cet ouvrage, remarquable par s..

Les métamorphoses de Sweeney

La légende de Sweeney, dont les premières traces apparaissent en Irlande dans des manuscrits du Moyen-âge, a frappé l’imagination de nombreux auteurs contemporains au rang desquels le prix Nobel Seamus Heaney. Ce « mystérieux roi poète métamorphosé en oiseau et condamné à la folie et à l’errance » (7), personnage à la fois tragique et grotesque a déployé ses ailes sur la littérature irlandaises de notre époque, pour inspirer chef d’œuvre après chef-d’œuvre. Dans cet ouvrage, remarquable par s..

Un bien pour un mal... des améliorations sanitaires pernicieuses

Tout projet de développement hydraulique s’accompagne d’importants bouleversements et revivifie la question des maladies hydriques. Il s'agit de comprendre un système eau/santé qui se modifie à mesure qu'il est observé. Nous nous sommes donc placée au cœur de la ville principale de Chennai, la première à restructurer toute son hydraulique urbaine. L'intérêt a été recentré autour de trois maladies traceuses - le choléra O139, la leptospirose humaine, la dengue - et leurs temps d'apparition particuliers. Elles se situent aux différents stades du système d'alimentation en eau domestique (desserte - évacuation - stockage) et résument avant tout ce qui s'est passé au cours des années 90. Au-delà, ces trois maladies posent clairement la question de la modification de la responsabilité des différents acteurs en présence et du risque épidémique lui-même. Elles vont en fait trouver dans les stratégies hydrauliques et les améliorations sanitaires de Chennai, les conditions propices à leur recrudescence intra-urbaine.Every hydraulic development project implies important changes and raises the question of water-borne diseases. The primary objective is to understand a water/health system which changes as it is observed. We therefore chose to work on the case of the major city of Chennai, the first to restructure its entire urban water system. The study is centred on three traceable diseases – O139 cholera, human leptospirosis and dengue fever – and the specific moments at which they appear. They are located at different points of the domestic water provision process (supply, evacuation, storage) and, above all, they reflect the events of the 1990s'. Beyond all that, these three diseases raise the question of the responsibilities of the various players and, indeed, of the epidemic risk itself. In fact, the ideal conditions for fresh outbreaks are to be found in the hydraulic strategies and sanitation improvements of the city of Chennai itself

Prévention des risques bucco-dentaires chez la femme enceinte

La grossesse est un état physiologique spécifique ; en effet, le corps de la femme enceinte subit de nombreux changements afin de porter l'enfant. Il est important de connaître ces modifications car elles ont des répercussions sur la santé buccale de la femme et sur la santé du futur enfant. Le chirurgien-dentiste doit également prendre en compte ces différences car la grossesse nécessite une prise en charge adaptée, avec des précautions lors des soins et des conseils pour une hygiène bucco-dentaire rigoureuse.La prévention reste la meilleure solution pour éviter l'apparition des problèmes bucco-dentaires. Les futurs parents sont en général très réceptifs aux informations sur la santé de leur enfant, c'est donc eux qu'il faut éduquer afin qu'ils transmettent les bonnes règles d'hygiène buccale.REIMS-BU Santé (514542104) / SudocPARIS-BIUM (751062103) / SudocLILLE2-UFR Odontologie (593502202) / SudocSudocFranceF

Development of radioactive beams at ALTO: Part 1. Physicochemical comparison of different types of UCx_x targets using a multivariate statistical approach

International audienceThe optimization of the microstructure of the UCx target is a key point since many years in the field of ISOL method. The ultimate goal is to facilitate the release of the fission products, especially those with short half-lives. Fourteen UCx samples were synthetized from different uranium and carbon sources using three mixing protocols. All carburized samples were systematically characterized in terms of nature and proportion phases, grain and aggregate size, open and close porosity proportion and open pore size distribution. Our results were analysed using a multivariate statistical approach in order to remove any subjective bias. Strong correlations between the physicochemical characteristics of the samples as well as the impact of the synthesis process have been highlighted. In particular, using carbon nanotubes as carbon source combined with a new method of mixing is the key parameter to limit the sintering and to obtain samples with small grains and a high porosity well distributed over small pores. Moreover the microstructure obtained proved to be stable at high temperature

Surface functionalization of cyclic olefin copolymer with aryldiazonium salts: A covalent grafting method

International audienceCovalent immobilization of biomolecules on the surface of cyclic olefin copolymer (COC) is still a tough challenge. We developed a robust method for COC surface grafting through reaction with aryldiazonium. Chemical diazonium reduction generated an aryl radical and the formation of a grafted film layer on the organic surface. We also demonstrated that the chemical reduction of diazonium salt was not sufficient to form a film on the COC surface. UV illumination had to be combined with chemical reduction to graft an aryl layer onto the COC surface. We optimized organic film deposition by using different chemical reducers, different reaction times and reagent proportions. We characterized surface modifications by fluorescence microscopy and contact angle measurements, infrared spectroscopy, X-ray photoemission spectroscopy and Raman spectroscopy, and assessed the topography of the aryl film by atomic force microscopy. This original strategy allowed us to evidence various organic functions to graft biomolecules onto COC surfaces with a fast and efficient technique

Erwinia amylovora type three-secreted proteins trigger cell death and defense responses in Arabidopsis thaliana

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Targeting connexin 43 prevents platelet-derived growth factor-BB-induced phenotypic change in porcine coronary artery smooth muscle cells

We previously reported that reducing the expression of the gap junction protein connexin (Cx)43 in mice restricts intimal thickening formation after acute vascular injury by limiting the inflammatory response and the proliferation and migration of smooth muscle cells (SMCs) toward the damaged site. SMC populations isolated from porcine coronary artery exhibit distinct phenotypes: spindle-shaped (S) and rhomboid (R). S-SMCs are predominant in the normal media, whereas R-SMCs are recovered in higher proportion from stent-induced intimal thickening, suggesting that they participate in the restenotic process. Here, we further investigate the relationship between connexin expression and SMC phenotypes using porcine coronary artery SMCs. Cx40 was highly expressed in normal media of porcine coronary artery in vivo, whereas Cx43 was barely detectable. In contrast, Cx40 was downregulated and Cx43 was markedly upregulated in stent-induced intimal thickening. In vitro, S-SMCs expressed Cx40 and Cx43. In R-SMCs, Cx43 expression was increased and Cx40 was absent. We confirmed that S-SMCs treated with platelet-derived growth factor-BB acquire an R phenotype. This was accompanied by an upregulation of Cx43 and a loss of Cx40. Importantly, platelet-derived growth factor-BB-induced S-to-R phenotypic change was prevented by a reduction of Cx43 expression with antisense, ie, S-SMCs retained their typical elongated appearance and the expression of alpha-smooth muscle actin, a well-known SMC differentiation marker, whereas the expression of S100A4, a typical marker of R-SMCs, was prevented. In conclusion, limiting Cx43 expression in S-SMCs prevents platelet-derived growth factor-BB-induced S-to-R modulation. This suggests that Cx43 may be an additional target for local delivery strategies aimed at reducing restenosis

Efficacy and safety of nicotinamide in haemodialysis patients: the NICOREN study (vol 32, pg 870, 2017)

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