244 research outputs found

    Creative Arts Personal Growth (CAPG) Group Leader Manual

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    CAPG focuses on forming a safe community to process and recover from feelings of fear and shame, as seen in the sub-title: Transforming Fear and Shame with Compassion, Courage, and Community. Why make the focus of a personal growth or counseling group fear and shame? Shame, which includes the experience of fear, has been described as a trans-diagnostic, underlying cause of many clinical concerns. CAPG combines best practices for the treatment of shame and fear and explicitly focuses on helping participants form a safe, inclusive relationship with one another to heal from shame

    Can Carbon Sinks be Operational? An RFF Workshop Summary

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    An RFF Workshop brought together experts from around the world to assess the feasibility of using biological sinks to sequester carbon as part of a global atmospheric mitigation effort. The chapters of this proceeding are a result of that effort. Although the intent of the workshop was not to generate a consensus, a number of studies suggest that sinks could be a relatively inexpensive and effective carbon management tool. The chapters cover a variety of aspects and topics related to the monitoring and measurement of carbon in biological systems. They tend to support the view the carbon sequestration using biological systems is technically feasible with relatively good precision and at relatively low cost. Thus carbon sinks can be operational.carbon, sinks, global warming, sequestration, forests

    The Creative Arts Personal Growth Group (CAPG): Transforming Fear and Shame

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    Literature highlights the long-term effects of bullying and interpersonal cruelty, including symptoms of trauma and shame. Although scholars have encouraged the development of trauma-informed group interventions for adults with a history of bullying, they have yet to be developed. This article introduces The Creative Arts Personal Growth Group: Transforming Fear and Shame with Compassion, Courage, and Community (CAPG) and presents findings from a phenomenlogocial pilot study exploring participants’ experiences. Themes of containment, creativity, and community promoted regulation of symptoms and selfidentity within the context of a safe, inclusive, and affirming group experience. Implications and recommendations are provided

    A natural histone H2A variant lacking the Bub1 phosphorylation site and regulated depletion of centromeric histone CENP-A foster evolvability in Candida albicans.

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    Eukaryotes have evolved elaborate mechanisms to ensure that chromosomes segregate with high fidelity during mitosis and meiosis, and yet specific aneuploidies can be adaptive during environmental stress. Here, we identify a chromatin-based system required for inducible aneuploidy in a human pathogen. Candida albicans utilizes chromosome missegregation to acquire tolerance to antifungal drugs and for nonmeiotic ploidy reduction after mating. We discovered that the ancestor of C. albicans and 2 related pathogens evolved a variant of histone 2A (H2A) that lacks the conserved phosphorylation site for kinetochore-associated Bub1 kinase, a key regulator of chromosome segregation. Using engineered strains, we show that the relative gene dosage of this variant versus canonical H2A controls the fidelity of chromosome segregation and the rate of acquisition of tolerance to antifungal drugs via aneuploidy. Furthermore, whole-genome chromatin precipitation analysis reveals that Centromere Protein A/ Centromeric Histone H3-like Protein (CENP-A/Cse4), a centromeric histone H3 variant that forms the platform of the eukaryotic kinetochore, is depleted from tetraploid-mating products relative to diploid parents and is virtually eliminated from cells exposed to aneuploidy-promoting cues. We conclude that genetically programmed and environmentally induced changes in chromatin can confer the capacity for enhanced evolvability via chromosome missegregation
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