Desain Prototype Web Pelayanan Jasa Laundry Dengan Model Fast

Jasa Laundry merupakan pelayanan jasa untuk melayani berbagai jenis pakaian, karpet, sepatu dan sejenisnya yang digunakan oleh masyarakat. Pada era sekarang ini masyarakat sangat memerlukan palayanan jasa laundry ini dengan salah satu meringankan pekerjaan yang dilakukan secara praktis dan sangat berkembang pesat. Adapun alasan mengapa masyarakat sangat memerlukan jasa ini karenadapat menghematwaktu, lebih rapi, wangi, pakaian jadi awat serta sudah menjadi bagian dari bisnis oleh masyarakat. Beberapa pebisnis yang ada dikalangan masyarakat sudah sangan banyak mengembangkan bisnis jasa laundry ini. Maka dari itu sistem yang dibuat ini dengan mendesain prototype web pelayanan jasa laundry dengan menggunakan model fast.  Dalam  penelitian  ini  menggunakan model pengembangan sistem Fast, metode berorienasi objek dan tool UML. Implementasi yang digunakan melalui sistem berbasis web. Diharapkan supaya mempermudah masyarakat dalam fasilias pelayanan jasa laundry dengan baik

Small manometers improve bag and mask ventilation: a manikin study

INTRODUCTION: Self-inflating bags (SIB) remain widely used for neonatal resuscitation. Insufflation pressures from SIB are difficult to assess and can be inadequate. Ventilation monitoring improves pressure control, but is not accessible to most resuscitators. Small spring manometer or a pressure line to a needle and dial manometer can be connected through a side port on the SIB. Those devices are cheap and easily available, but their efficacy needs to be assessed. Observation of the manometer could also be considered as a distraction, with increased risk of leak or inadequate insufflation rate. We therefore aimed to evaluate the effect of mechanical manometers on the quality of insufflations with a SIB. MATERIALS AND METHODS: Participants to the Belgian Pediatric Society meeting were invited to ventilate a manikin with a 300 ml SIB. The leak-free manikin was modified with a flow-meter at tracheal level connected to a neonatal test lung. Participants had to aim for a 25 mbar pressure and a rate of 40-60 during 3 sequences of 45 seconds. A spring (S), a dial (D) manometer or nothing (N) was added to the SIB in random sequence. Pressure data from the SIB and flow data from the manikin were obtained through a ventilation monitor. Peak pressure (PIP), tidal volume (VTi), and insufflations rate (RR) were calculated for each breath. Theoretical leak was evaluated by subtracting real from theoretical volumes derived from a leak free calibration (taped facemask). Data were analyzed with ANOVA and posthoc Bonferroni. RESULTS Five neonatologists (Neo), 15 pediatricians (Ped) and 11 residents ventilated the manikin for a total of 5279 insufflations. Manometer use was associated with an increase in PIP (N: 17+-6 mbar; S: 18+-4 mbar*; D: 19+-4 mbar*#) [*p<.05 vs N; #:p<.05 vs S]. Changes in VTi (N: 3+-1 ml; S: 3.1+-1 ml*; D: 3.2+-1 ml*) and RR (77-82 bpm) were small. Leak did not increase. The effect of manometer use on PIP, VTi and leak was more important with Neo (PIP-N: 16+-7 mbar; S and D: 20+-4 mbar*) and Ped. With residents, no change occurred in PIP (~17 mbar), Vti (2.9 ml) or leak (31-35%). However, for first sequences of ventilation, manometer use was associated with higher PIP (N: 12+-4 mbar; S: 16+-3 mbar*; D: 20+-4 mbar*#), VTi (N:2+-1 ml; S:3+-0.8 ml*; D:3.3+-1 ml*#) and lower leaks (N: 38+-16%; S: 27+-12%*; D: 34+-13%*#). This observation for first sequences was found in all 3 categories of providers. CONCLUSIONS Bag and mask ventilation remains difficult. In this model, the addition of a manometer is associated with improved pressures and VTi, and with decreased theoretical leak. This effect is predominant for initial (“naïve”) ventilation with a dial manometer, and is also related to operator experience. Small, inexpensive manometers have the potential to improve SIB ventilation of newborn infants

Différents manomètres pour améliorer la ventilation au masque et ballon

peer reviewedINTRODUCTION Les pressions employées lors de la ventilation au ballon sont difficiles à évaluer et souvent inadéquates. Les ballons disposent d’un connecteur où brancher un manomètre (manom) à ressort ou une ligne vers un manom à cadran. Cependant, l’addition d’une variable à surveiller pourrait constituer une interférence et majorer le risque de fuite ou de rythme ventilatoire inadéquat. Cette étude évalue l’influence de manom simples sur la qualité de la ventilation. MÉTHODES Les participants aux Journées Belges de Pédiatrie pouvaient ventiler un mannequin aux voies respiratoires étanches avec un capteur de débit trachéal. Une pression de 25 mbar et une fréquence de 40 à 60/’ étaient visées. Une séquence de 45’’ avec un manom à ressort (R), une séquence avec un manom à cadran (C) et une sans (O) étaient réalisées dans un ordre aléatoire. La pression de pointe du ballon (P), le volume inspiratoire (VTi), et la fréquence de ventilation (FR) de chaque insufflation ont été analysées. La fuite autour du masque fut estimée en comparant VTi à un volume théorique dérivé d’une calibration avec masque scellé. RÉSULTATS Cinq néonatologues (Néo), 15 pédiatres et 11 internes ont réalisé 5279 insufflations. Les P obtenues avec un manom étaient plus élevées (O:176 mbar; R:184 mbar*; C:194 mbar*#) [*p<.05 vs O; #:p<.05 vs R] VTi augmentait légèrement (O:31 ml; R:3.11 ml*; C:3.21 ml*) FR était systématiquement trop élevé (77-82 bpm). L’usage d’un manom ne modifiait pas les paramètres pour les internes. Pour les Néo, ajouter un manom améliorait P, VTi et la fuite (P -O: 167 mbar; R and C: 204 mbar*) Sur les premières séquences de ventilation, le manom améliorait les paramètres (P-O: 124 mbar;R: 163 mbar*; C: 204 mbar*#), (VTi-O:21 ml; R:30.8 ml*; C:3.31 ml*#), (Fuite-O: 3816%; R: 2712%*; C: 3413%*#). CONCLUSIONS La ventilation au ballon reste difficile. Les pressions obtenues étaient éloignées de l’objectif, et le rythme souvent trop élevé. Si le manomètre permet d’améliorer les pressions et volumes obtenus, surtout en cas de ventilation sans feed-back préalable, cet effet bénéfique s’observe surtout pour les opérateurs expérimentés. Enfin, un congrès scientifique permet de recruter une population variée pour une étude de simulation simple

Structural and biological characterization of new hybrid drugs joining an HDAC inhibitor to different NO-donors

HDAC inhibitors and NO donors have already revealed independently their broad therapeutic potential in pathologic contexts. Here we further investigated the power of their combination in a single hybrid molecule. Nitrooxy groups or substituted furoxan derivatives were joined to the α-position of the pyridine ring of the selective class I HDAC inhibitor MS-275. Biochemical analysis showed that the association with the dinitrooxy compound 31 or the furoxan derivative 16 gives hybrid compounds the ability to preserve the single moiety activities. The two new hybrid molecules were then tested in a muscle differentiation assay. The hybrid compound bearing the moiety 31 promoted the formation of large myotubes characterized by highly multinucleated fibers, possibly due to a stimulation of myoblast fusion, as implicated by the strong induction of myomaker expression. Thanks to their unique biological features, these compounds may represent new therapeutic tools for cardiovascular, neuromuscular and inflammatory diseases

Introdução: o que nos carregou até o sangue?

Substância, metáfora, líquido essencialmente vinculado à vida, associado à movimentação, ao veículo de coisas das mais diversas, como identidades. O sangue, vital para humanos e não-humanos, possui muitas existências, significações e interpretações, das quais a Antropologia desde os seus primórdios soube se valer. Ainda em1871, Morgan publicava Systems of Consanguinity and Affinity of the Human Family e desde então, as questões em torno do sangue nunca deixaram de interessar aos antropólogos. Nos estudos de parentesco, campo em que a temática se demonstrou especialmente frutífera, as abordagens sobre o sangue foram desenvolvidas e ampliadas, deslocando e movimentando as próprias compreensões sobre parentesco. No desenvolvimento da disciplina, os horizontes de análise se ampliaram: do sangue enquanto analogia para hereditariedade ao sangue enquanto substância que compõe pessoas e vínculos. Com isso, sua fluidez permitiu movimentar outras substâncias, criando circulações, sistemas, corpos

DIABETES MELLITUS TIPO 1: PERFIL GLICÊMICO E CONSUMO ALIMENTAR EM UM AMBULATÓRIO DE NUTRIÇÃO PEDIÁTRICA

Objetivo: investigar o perfil glicêmico e o consumo alimentar de crianças e adolescentes assistidos em um ambulatório de nutrição pediátrica do Sistema Único de Saúde do sul do Brasil. Métodos: estudo longitudinal, com dados de controle glicêmico coletados dos prontuários de saúde, na consulta inicial e final. O consumo alimentar foi avaliado após a realização de dois recordatórios de 24 horas aplicados durante a semana, incluindo a segunda-feira. Resultados: verificou-se que os parâmetros de controle glicêmico mostraram melhora no período de acompanhamento. O consumo dos principais grupos alimentares fonte de carboidratos foi adequado às recomendações vigentes. Entretanto, o consumo do grupo das carnes foi excessivo e o das frutas, dos legumes e verduras foi insuficiente. Conclusão: Após o período de acompanhamento o perfil glicêmico mostrou melhora em crianças e adolescentes com diabetes mellitus tipo 1. O consumo alimentar foi caracterizado pela adequação de porções de alimentos fonte de açúcares, excesso de porções carnes e ovos e quantidade insuficiente de frutas, dos legumes e verduras