Mechanisms Underlying Weight Loss and Metabolic Improvements in Rodent Models of Bariatric Surgery

Obesity is a growing health risk with few successful treatment options and fewer still that target both obesity and obesity-associated comorbidities. Despite ongoing scientific efforts, the most effective treatment option to date was not developed from basic research but by surgeons observing outcomes in the clinic. Bariatric surgery is the most successful treatment for significant weight loss, resolution of type 2 diabetes and the prevention of future weight gain. Recent work with animal models has shed considerable light on the molecular underpinnings of the potent effects of these ‘metabolic’ surgical procedures. Here we review data from animal models and how these studies have evolved our understanding of the critical signalling systems that mediate the effects of bariatric surgery. These insights could lead to alternative therapies able to accomplish effects similar to bariatric surgery in a less invasive manner

Optimal Policy Derivation for Transmission Duty-Cycle Constrained LPWAN

Low-power wide-area network (LPWAN) technologies enable Internet of Things (IoT) devices to efficiently and robustly communicate over long distances, thus making them especially suited for industrial environments. However, the stringent regulations on the usage of certain industrial, scientific, and medical bands in many countries in which LPWAN operate limit the amount of time IoT motes can occupy the shared bands. This is particularly challenging in industrial scenarios, where not being able to report some detected events might result in the failure of critical assets. To alleviate this, and by mathematically modeling LPWAN-based IoT motes, we have derived optimal transmission policies that maximize the number of reported events (prioritized by their importance) while still complying with current regulations. The proposed solution has been customized for two widely known LPWAN technologies: 1) LoRa and 2) Sigfox. Analytical results reveal that our solution is feasible and performs remarkably close to the theoretical limit for a wide range of network activity patterns

Enhancement of entanglement in one-dimensional disordered systems

The pairwise quantum entanglement of sites in disordered electronic one-dimensional systems (rings) is studied. We focus on the effect of diagonal and off diagonal disorder on the concurrence $C_{ij}$ between electrons on neighbor and non neighbor sites $i,j$ as a function of band filling. In the case of diagonal disorder, increasing the degree of disorder leads to a decrease of the concurrence with respect to the ordered case. However, off-diagonal disorder produces a surprisingly strong enhancement of entanglement. This remarkable effect occurs near half filling, where the concurrence becomes up to 15% larger than in the ordered system.Comment: 21 pages, 9 figure

Damages caused by cotton rat, Sigmodon hispidus zanjonensis, on sugar cane in San Pedrosula, Honduras

Technical assistance was given to Compañía Azucarera Hondureña, S.A. (Agro-Industrial Co.), Honduras, Central America, to determine if a campaign against noxious rodents to agriculture crops was needed. Several trappings were carried out at different places using snap traps to determine the population structure of rodents associated with the crop, and live traps to determine the index or density of the Sigmodon hispidus rat population, which was identified as being responsible for the damage to sugarcane. Results were 43.24% adult males, 14.86% young males, 31.41% adult females, and 10.47% young females. Of the adult females captured, 54.83% were pregnant with an average of 3 to 4 embryos per rat. A control demonstration combat was carried out at one of the experimental stations with a bait prepared with 2% zinc phosphide in a place where it had been previously determined there was a population of 39 rats per hectare. After such control, the population was reduced to 18 rats per hectare, which represents an efficiency of 53.85%. An evaluation of damages was also measured at different places to determine the degree of loss caused by the rats, which proved to be 22.79% damage. The size of the sample was estimated in 3 samples per hectare, with a level of confidence of 95%

Metabolic Effects of Bariatric Surgery in Mouse Models of Circadian Disruption

Background/Objectives: Mounting evidence supports a link between circadian disruption and metabolic disease. Humans with circadian disruption (for example, night-shift workers) have an increased risk of obesity and cardiometabolic diseases compared with the non-disrupted population. However, it is unclear whether the obesity and obesity-related disorders associated with circadian disruption respond to therapeutic treatments as well as individuals with other types of obesity. Subjects/Methods: Here, we test the effectiveness of the commonly used bariatric surgical procedure, Vertical Sleeve Gastrectomy (VSG), in mouse models of genetic and environmental circadian disruption. Results: VSG led to a reduction in body weight and fat mass in both ClockΔ19 mutant and constant-light mouse models (PP\u3e0.05). Within circadian-disrupted models, VSG also led to improved glucose tolerance and lipid handling (P\u3c0.05). Conclusions: Together these data demonstrate that VSG is an effective treatment for the obesity associated with circadian disruption, and that the potent effects of bariatric surgery are orthogonal to circadian biology. However, as the effects of bariatric surgery are independent of circadian disruption, VSG cannot be considered a cure for circadian disruption. These data have important implications for circadian-disrupted obese patients. Moreover, these results reveal new information about the metabolic pathways governing the effects of bariatric surgery as well as of circadian disruption

Wetting pattern of cow urine patch in an Andisol assessed through bromide concentration distribution: A pilot study

Cow urine is a rich source of mobile nutrients such as nitrate (NO3−) and potassium (K+). The aim of this experiment was to evaluate the wetting pattern distribution through soil profile of cow urine patch in an andisol. Two field experiments across two consecutive years were carried out to compare cow urine patches in relation to initial wetting pattern and volume of soil affected. Bromide (Br−) has successfully been used as an inert hydrologic tracer to indicate the movement of NO3− and K+ in soil–water systems. The distribution of Br− (used as a urine tracer) on the soil surface and down the profile was irregular in all the patches. Cow urine patches covered a surface area of 0.27 and 0.35 m2, respectively, and penetrated to a depth of 70 cm. The rapid downward movement of urine occurred through macropore flow but even so, between 27% and 40% of the applied Br- was detected in the 0–5 cm soil layer. Br− showed concentrations greater than 1500 mg kg−1 and up to 3000 mg kg−1, and as the concentration of Br− decreases, the frequency and depth of affected layers increases. Despite the differences in moisture and in the distribution of the Br− concentration in both years, the concentration frequency of 500 to 1500 mg kg−1 represented around 37% of the affected volume of soil (bulb of urine) in both years. Up to 40% of the bulb represented N equivalent rates between 187 and 975 kg N ha−1. These values can potentially be emitted in gases such as NH3, N2O, and N2. It is suggested that the presence of N in the volume of affected soil could vary due to the moisture content of the soil, and that in andisols of southern Chile under permanent grasslands there are a large number of macropores that would induce preferential flows

Interaction energy functional for lattice density functional theory: Applications to one-, two- and three-dimensional Hubbard models

The Hubbard model is investigated in the framework of lattice density functional theory (LDFT). The single-particle density matrix $\gamma_{ij}$ with respect the lattice sites is considered as the basic variable of the many-body problem. A new approximation to the interaction-energy functional $W[\gamma]$ is proposed which is based on its scaling properties and which recovers exactly the limit of strong electron correlations at half-band filling. In this way, a more accurate description of $W$ is obtained throughout the domain of representability of $\gamma_{ij}$, including the crossover from weak to strong correlations. As examples of applications results are given for the ground-state energy, charge-excitation gap, and charge susceptibility of the Hubbard model in one-, two-, and three-dimensional lattices. The performance of the method is demonstrated by comparison with available exact solutions, with numerical calculations, and with LDFT using a simpler dimer ansatz for $W$. Goals and limitations of the different approximations are discussed.Comment: 25 pages and 8 figures, submitted to Phys. Rev.