8 research outputs found
Frequency and prognosis of associated malignancies in 504 patients with lymphomatoid papulosis
- Author
- Publication venue
- 'Wiley'
- Publication date
- 12/11/2019
- Field of study
Get PDFBackground: Lymphomatoid papulosis (LyP) can be associated with other haematological malignancies (HM), but reported percentages vary from 20% to over 50%. Objective: To evaluate the frequency and prognostic significance of associated HM and non-HM in LyP patients. Methods: In this multicentre cohort study, the complete Dutch LyP population was included from the Dutch Cutaneous Lymphoma Registry between 1985 and 2018. Clinical and histopathological information was retrieved from every individual patient. Results: After a median follow-up of 120 months (range, 6â585), an associated HM was observed in 78/504 (15.5%) patients. Most common associated HM were mycosis fungoides (MF; n = 31) and anaplastic large-cell lymphoma (ALCL; n = 29), while 19 patients had another HM of B-cell (n = 14) or myeloid origin (n = 5). Even after a 25-year follow-up period, percentages of associated HM did not exceed 20%. Thirty-nine of 465 patients (8.4%) without a prior or concurrent associated HM developed an associated HM during follow-up, after a median of 68 months (range of 3â286 months). Nine of 78 patients died of associated HM, including 6/22 patients developing extracutaneous ALCL, while all patients with associated MF or skin-limited ALCL had an excellent prognosis. Compared with the general population, LyP patients showed an increased risk (relative risk, 2.8; 95% confidence intervals, 2.4â3.3) for non-HM, in particular cutaneous squamous cell carcinoma, melanoma and intestinal/lung/bladder cancer. Conclusions: An associated HM was reported in 15.5% of the LyP patients, particularly MF and ALCL. Although the frequency of associated HM is lower than suggested and the prognosis of most patients with associated HM is excellent, a small subgroup will develop aggressive disease, in particular extracutaneous ALCL. Furthermore, LyP patients have a higher risk of developing other malignancies. Clinicians should be aware of these risks, and LyP patients require close monitoring
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- Publication venue
- IOP Publishing
- Publication date
- 01/05/2024
- Field of study
Get PDFThe LHCb upgrade represents a major change of the experiment. The detectors have been almost completely renewed to allow running at an instantaneous luminosity five times larger than that of the previous running periods. Readout of all detectors into an all-software trigger is central to the new design, facilitating the reconstruction of events at the maximum LHC interaction rate, and their selection in real time. The experiment's tracking system has been completely upgraded with a new pixel vertex detector, a silicon tracker upstream of the dipole magnet and three scintillating fibre tracking stations downstream of the magnet. The whole photon detection system of the RICH detectors has been renewed and the readout electronics of the calorimeter and muon systems have been fully overhauled. The first stage of the all-software trigger is implemented on a GPU farm. The output of the trigger provides a combination of totally reconstructed physics objects, such as tracks and vertices, ready for final analysis, and of entire events which need further offline reprocessing. This scheme required a complete revision of the computing model and rewriting of the experiment's software
Forgotten Villages, the Effects of the Crisis and the Role of the Government in Rural Java
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- 01/01/2002
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No full textIncidence of mycosis fungoides and Sezary syndrome in the Netherlands between 2000 and 2020
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- 'Wiley'
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- 01/01/2021
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Get PDFDermatology-oncolog
Recommendations for the Optimal Radiation Dose in Patients With Primary Cutaneous Anaplastic Large Cell Lymphoma: A Report of the Dutch Cutaneous Lymphoma Group
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- 'Elsevier BV'
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- 01/01/2017
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No full textDermatology-oncolog
Outcomes of rare patients with a primary cutaneous CD30(+) lymphoproliferative disorder developing extracutaneous disease
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- 'American Society of Hematology'
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- 01/01/2020
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No full textContains fulltext :
218224.pdf (Publisherâs version ) (Open Access
Phenotypic variability in patients with ADA2 deficiency due to identical homozygous R169Q mutations
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- 'Oxford University Press (OUP)'
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- 31/05/2016
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No full textTransplantation and immunomodulatio
The LHCb upgrade I
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- Aaij Roel
- Abdelmotteleb Ahmed Sameh Wagih
- Abellan Beteta Carlos
- Abudinén Fernando Jesus
- Achard Cyrille
- Ackernley Thomas
- Adeva Bernardo
- Adinolfi Marco
- Adlarson Patrik Harri
- Afsharnia Hossein
- Agapopoulou Christina
- Aidala Christine Angela
- Ajaltouni Ziad
- Akar Simon
- Akiba Kazuyoshi
- Albicocco Pietro
- Albrecht Johannes
- Alessio Federico
- Alexander Michael
- Alfonso Albero Alejandro
- Aliouche Zakariya
- Alvarez Cartelle Paula
- Amalric Renaud
- Amato Sandra
- Amey Jake Lewis
- Amhis Yasmine
- An Liupan
- Anderlini Lucio
- Andersson Martin
- Andreani Alessandro
- Andreianov Aleksei
- Andreotti Mirco
- Andreou Dimitra
- Andrews Jason
- Anelli Mario
- Anjam Andrea
- Ao Dong
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- Ashby Joe
- Aslanides Elie
- Atzeni Michele
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- Bachmann Sebastian
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- Bartolini Matteo
- Baryshnikov Fedor
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- Batista Lopes Joao Carlos
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- Bediaga Ignacio
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- Belous Konstantin
- Belov Ilia
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- Berezhnoy Alexander
- Bernard Florian
- Bernet Andres Sergi
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- Betti Federico
- Bezshyiko Ia.
- Bezshyiko Iaroslava
- Bezshyyko Oleg
- Bhasin Srishti
- Bhom Jihyun
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- Campoverde Quezada Angel Fernando
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- Chen Chen
- Chen Shanzhen
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- Chulikov Vladimir
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- Ding Shuchong
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- Dordei Francesca
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- Fernandez Prieto A.
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- Gerick David
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- Getz Stanislav A.
- Giambastiani Luca
- Gibson Valerie
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- Gironella Gironell Pere
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- Gkougkousis Evangelos Leonidas
- Gligorov Vladimir
- Golinka-Bezshyyko Larysa
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- Golutvin Andrey
- Gomes Alvaro
- Gomez Fernandez Sergio
- Goncalves Abrantes Fernanda
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- Gorelov Igor Vladimirovich
- Gotti Claudio
- Grabowski Jascha Peter
- Grammatico Thomas
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- Hadjivasiliou Christos
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- Haen Christophe
- Haimberger Jakob
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- Halewood-leagas Tabitha
- Halvorsen Marius Maehlum
- Hamilton Phoebe Meredith
- Hammerich Jan
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- Hansmann-Menzemer Stephanie
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- Hennequin Arthur Marius
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- Hilton Martha
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- Hollitt Sophie
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- Jage Hendrik
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- Karacson Matthias
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- Yang Shuangli
- Yang Xueting
- Yang Youhua
- Yang Zhenwei
- Yang Zishuo
- Yeomans Lauren Emma
- Yeroshenko Vsevolod
- Yeung Ho Yin Dereck
- Yin Hang
- Yu Jiesheng
- Yuan Xuhao
- Zaffaroni Ettore
- Zavertyaev Mikhail
- Zdybal Milosz
- Zenaiev Oleksandr
- Zeng Ming
- Zhang Chenjia
- Zhang Dongliang
- Zhang Liming
- Zhang Shulei
- Zhang Shunan
- Zhang Yanxi
- Zhang Yu
- Zhao Ya
- Zharkova Alina
- Zhelezov Alexey
- Zheng Yangheng
- Zhou Tianwen
- Zhou Xiaokang
- Zhou Yixiong
- Zhovkovska Valeriia
- Zhu Xianglei
- Zhu Xiaoyu
- Zhu Zhanwen
- Zhukov Valery
- Zivkovic Vladimir
- Zou Quan
- Zucchelli Stefano
- Zuliani Davide
- Zunica Gianluca
- Zvyagintsev Sergey
- Publication venue
- HAL CCSD
- Publication date
- 17/05/2023
- Field of study
No full textInternational audienceThe LHCb upgrade represents a major change of the experiment. The detectors have been almost completely renewed to allow running at an instantaneous luminosity five times larger than that of the previous running periods. Readout of all detectors into an all-software trigger is central to the new design, facilitating the reconstruction of events at the maximum LHC interaction rate, and their selection in real time. The experiment's tracking system has been completely upgraded with a new pixel vertex detector, a silicon tracker upstream of the dipole magnet and three scintillating fibre tracking stations downstream of the magnet. The whole photon detection system of the RICH detectors has been renewed and the readout electronics of the calorimeter and muon systems have been fully overhauled. The first stage of the all-software trigger is implemented on a GPU farm. The output of the trigger provides a combination of totally reconstructed physics objects, such as tracks and vertices, ready for final analysis, and of entire events which need further offline reprocessing. This scheme required a complete revision of the computing model and rewriting of the experiment's software
