Gross output and livestock sales modelling in Spanish extensive farms using PLSR

The aim of this paper is to model some production variables in extensive livestock farms located in the dehesa ecosystem. We intend to use not only purely economic variables in the construction of the model, but also structural variables in order to identify the characteristics of the farms that have the higher influence. Another objective is to be able to predict these variables at the farm level, using structural variables that are easy to measure. The data used in this work were obtained from a questionnaire survey to the holders/managers of a sample of 69 dehesa farms in Extremadura (SW Spain). The statistical methodology used for the construction of the model was Partial Least Square Regression (PLSR). It can be concluded that the variables relative to farm intensification, to labour and especially to Iberian pig breeding, are those that take part mainly in the model.dehesa, livestock farming systems, partial least square regression, gross output, Crop Production/Industries, Livestock Production/Industries, Research Methods/ Statistical Methods,

OAF: a new member of the BRICHOS family

SUMMARY: The 10 known BRICHOS domain-containing proteins in humans have been linked to an unusually long list of pathologies, including cancer, obesity and two amyloid-like diseases. BRICHOS domains themselves have been described as intramolecular chaperones that act to prevent amyloid-like aggregation of their proteins' mature polypeptides. Using structural comparison of coevolution-based AlphaFold models and sequence conservation, we identified the Out at First (OAF) protein as a new member of the BRICHOS family in humans. OAF is an experimentally uncharacterized protein that has been proposed as a candidate biomarker for clinical management of coronavirus disease 2019 infections. Our analysis revealed how structural comparison of AlphaFold models can discover remote homology relationships and lead to a better understanding of BRICHOS domain molecular mechanism. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics Advances online

Perception Of Sustainability Of A Tourism Destination: Analysis From Tourist Expectations

This paper demonstrates that different assessments of the tourism attributes of a destination exist according to whether the perception of those tourists visiting that destination is that it is sustainable or whether, on the contrary, they perceive that it shows problems of unsustainability. Consequently, for a destination to be able to advance in terms of sustainability, it is not enough just to implement supply policies, but it is also necessary that its tourists are involved in this process as well; that is, demand policies must be developed that ensure a greater awareness and responsibility of tourists in the destinations they visit

Distribution and structure of the southernmost Caribbean coral reefs: golfo de Urabá, Colombia

The Gulf of Urabá represents the southernmost portion of the Caribbean Sea. Due to the large amounts of sediment and freshwater discharged by the Atrato river and several minor streams, water conditions in the area are far from being optimal for coral settlement and growth. However, fringing and patch reefs are developed along the rocky shores of the northwest margin of the Gulf. Based on field observations performed at 44 sites (12 of them assessed quantitatively), interpretation of air photography of the area and depth profiles, the distribution, structure and zonation of the reefs are described. Classification analysis of the 12 sample sites yielded four coral assemblages: Diploria strigosa, crustose algae, Siderastrea siderea, Agaricia spp., and mixed massive corals. Other two assemblages, dominated respectively by Millepora complanata and thickets of Acropora palmata were noticed during reconnaissance dives. The distribution of these zones within the reef seems likely to be mainly controlled by wave exposure, bottom topography, sedimentation, and light penetration. Reef development, coral diversity and live coral cover increase along the coast in a SE-NW direction, with an evident maximum near to the cove of Sapzurro, suggesting an overall improvement of conditions for coral growth and settlement in that direction. A total of 33 species of hard corals were recorded during the survey. It is apparent that the live coral cover, particularly of foliose and branching species, has notably declined recently

RAWUL: A new ubiquitin-like domain in PRC1 Ring finger proteins that unveils putative plant and worm PRC1 orthologs

<p>Abstract</p> <p>Background</p> <p>Polycomb group (PcG) proteins are a set of chromatin-modifying proteins that play a key role in epigenetic gene regulation. The PcG proteins form large multiprotein complexes with different activities. The two best-characterized PcG complexes are the PcG repressive complex 1 (PRC1) and 2 (PRC2) that respectively possess histone 2A lysine 119 E3 ubiquitin ligase and histone 3 lysine 27 methyltransferase activities. While PRC2-like complexes are conserved throughout the eukaryotic kingdoms, PRC1-like complexes have only been described in Drosophila and vertebrates. Since both complexes are required for the gene silencing mechanism in Drosophila and vertebrates, how PRC1 function is realized in organisms that apparently lack PRC1 such as plants, is so far unknown. In vertebrates, PRC1 includes three proteins, Ring1B, Ring1A, and Bmi-1 that form an E3 ubiquitin ligase complex. These PRC1 proteins have an N-terminally located Ring finger domain associated to a poorly characterized conserved C-terminal region.</p> <p>Results</p> <p>We obtained statistically significant evidences of sequence similarity between the C-terminal region of the PRC1 Ring finger proteins and the ubiquitin (Ubq)-like family proteins, thus defining a new Ubq-like domain, the RAWUL domain. In addition, our analysis revealed the existence of plant and worm proteins that display the conserved combination of a Ring finger domain at the N-terminus and a RAWUL domain at the C-terminus.</p> <p>Conclusion</p> <p>Analysis of the conserved domain architecture among PRC1 Ring finger proteins revealed the existence of long sought PRC1 protein orthologs in these organisms, suggesting the functional conservation of PRC1 throughout higher eukaryotes.</p

Refining the domain architecture model of the replication origin firing factor Treslin/TICRR

Faithful genome duplication requires appropriately controlled replication origin firing. The metazoan origin firing regulation hub Treslin/TICRR and its yeast orthologue Sld3 share the Sld3-Treslin domain and the adjacent TopBP1/Dpb11 interaction domain. We report a revised domain architecture model of Treslin/TICRR. Protein sequence analyses uncovered a conserved Ku70-homologous β-barrel fold in the Treslin/TICRR middle domain (M domain) and in Sld3. Thus, the Sld3-homologous Treslin/TICRR core comprises its three central domains, M domain, Sld3-Treslin domain, and TopBP1/Dpb11 interaction domain, flanked by non-conserved terminal domains, the CIT (conserved in Treslins) and the C terminus. The CIT includes a von Willebrand factor type A domain. Unexpectedly, MTBP, Treslin/TICRR, and Ku70/80 share the same N-terminal domain architecture, von Willebrand factor type A and Ku70-like β-barrels, suggesting a common ancestry. Binding experiments using mutants and the Sld3–Sld7 dimer structure suggest that the Treslin/Sld3 and MTBP/Sld7 β-barrels engage in homotypic interactions, reminiscent of Ku70-Ku80 dimerization. Cells expressing Treslin/TICRR domain mutants indicate that all Sld3-core domains and the non-conserved terminal domains fulfil important functions during origin firing in human cells. Thus, metazoa-specific and widely conserved molecular processes cooperate during metazoan origin firing

Multi-Channel Radio Resource Distribution Policies in Heterogeneous Traffic Scenarios

Multi-channel operation in wireless systems has been proposed to increase user throughput and reduce transmission delays. However, multi-channel operation requires adequate resource allocation policies to guarantee user fairness and avoid channel access stagnation. The definition of such policies is particularly challenging in heterogeneous traffic scenarios where each traffic service has different quality of service requirements. In this context, this work proposes and evaluates various multichannel radio resource distribution policies designed to operate under heterogeneous traffic environments. In particular, this paper proposes the application of bankruptcy policies to guarantee user fairness, and compares their performance to other schemes. The proposed policies can also be extended to manage radio resources in heterogeneous wireless systems

Managing daily surgery schedules in a teaching hospital: A mixed-integer optimization approach

This study examined the daily surgical scheduling problem in a teaching hospital. This problem relates to the use of multiple operating rooms and different types of surgeons in a typical surgical day with deterministic operation durations (preincision, incision, and postincision times). Teaching hospitals play a key role in the health-care system; however, existing models assume that the duration of surgery is independent of the surgeon?s skills. This problem has not been properly addressed in other studies. We analyze the case of a Spanish public hospital, in which continuous pressures and budgeting reductions entail the more efficient use of resources.Fil: Pulido, Raul. Politecnico Di Milano; Italia. Escuela Técnica Superior de Ingenieros Industriales; EspañaFil: Aguirre, Adrian Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); ArgentinaFil: Ortega Mier, Miguel. Escuela Técnica Superior de Ingenieros Industriales; EspañaFil: García Sanchez, Alvaro. Escuela Técnica Superior de Ingenieros Industriales; EspañaFil: Mendez, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Santa Fe. Instituto de Desarrollo Tecnológico Para la Industria Química (i); Argentin

TRANSFERENCIA DE CALOR DE ESTADO INESTABLE EN FORROS PARA FRENOS

Este artículo presenta una metodología para analizar el comportamiento térmico de forros para frenos, elementos que operan bajo procesos de transferencia de calor inestable. Se establecen la teoría y las pruebas experimentales necesarias para calcular la difusividad térmica, determinar los perfiles de temperatura y calcular el flujo de calor. Se realiza la comparación de resultados con las recomendaciones de la literatura del sector automotriz, planteando a la industria técnicas cuantitativas para evaluar el desempeño térmico de los elementos de frenado. Esta metodología puede ser aplicada para el análisis de cualquier material sólido con conducción de calor en estado inestable