Synthesis and Antimicrobial Activity of New a-Aminophosphonic Acid Esters

ABSTRACT Synthesis of new a-aminophosphonic acid esters (3a-l) was accomplished by the reaction of equimolar quantities of phenyl ethyl glycine and various aryl aldehydes with diethyl/ dimethylphosphite in dry toluene at reflux temperature. All the structures of the newly synthesized a-aminophosphonic acid esters (3a-l) were established by elemental analysis, and IR, 1 H, 13 C, 31 P NMR and mass spectral data. The antimicrobial and antifungal activities of these compounds were evaluated and they exhibited significant activity. KEYWORDS Phenyl glycine ethyl ester, aryl aldehydes, diethyl/dimethylphosphite, antimicrobial activity