4,280 research outputs found

    Breaking Rank: Party Influence in Congressional Defense Voting Since the Cold War

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    From the Washington University Senior Honors Thesis Abstracts (WUSHTA), Spring 2018. Published by the Office of Undergraduate Research. Joy Zalis Kiefer, Director of Undergraduate Research and Associate Dean in the College of Arts & Sciences; Lindsey Paunovich, Editor; Helen Human, Programs Manager and Assistant Dean in the College of Arts and Sciences Mentor: Steven Smit

    Dynamical susceptibility near a long-wavelength critical point with a nonconserved order parameter

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    We study the dynamic response of a two-dimensional system of itinerant fermions in the vicinity of a uniform (Q=0\mathbf{Q}=0) Ising nematic quantum critical point of dd-wave symmetry. The nematic order parameter is not a conserved quantity, and this permits a nonzero value of the fermionic polarization in the dd-wave channel even for vanishing momentum and finite frequency: Π(q=0,Ωm)0\Pi(\mathbf{q} = 0,\Omega_m) \neq 0. For weak coupling between the fermions and the nematic order parameter (i.e. the coupling is small compared to the Fermi energy), we perturbatively compute Π(q=0,Ωm)0\Pi (\mathbf{q} = 0,\Omega_m) \neq 0 over a parametrically broad range of frequencies where the fermionic self-energy Σ(ω)\Sigma (\omega) is irrelevant, and use Eliashberg theory to compute Π(q=0,Ωm)\Pi (\mathbf{q} = 0,\Omega_m) in the non-Fermi liquid regime at smaller frequencies, where Σ(ω)>ω\Sigma (\omega) > \omega. We find that Π(q=0,Ω)\Pi(\mathbf{q}=0,\Omega) is a constant, plus a frequency dependent correction that goes as Ω|\Omega| at high frequencies, crossing over to Ω1/3|\Omega|^{1/3} at lower frequencies. The Ω1/3|\Omega|^{1/3} scaling holds also in a non-Fermi liquid regime. The non-vanishing of Π(q=0,Ω)\Pi (\mathbf{q}=0, \Omega) gives rise to additional structure in the imaginary part of the nematic susceptibility χ(q,Ω)\chi^{''} (\mathbf{q}, \Omega) at Ω>vFq\Omega > v_F q, in marked contrast to the behavior of the susceptibility for a conserved order parameter. This additional structure may be detected in Raman scattering experiments in the dd-wave geometry

    Peroxisomal regulation of redox homeostasis and adipocyte metabolism

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    Peroxisomes are ubiquitous cellular organelles required for specific pathways of fatty acid oxidation and lipid synthesis, and until recently their functions in adipocytes have not been well appreciated. Importantly, peroxisomes host many oxygen-consumption reactions and play a major role in generation and detoxification of reactive oxygen species (ROS) and reactive nitrogen species (RNS), influencing whole cell redox status. Here, we review recent progress in peroxisomal functions in lipid metabolism as related to ROS/RNS metabolism and discuss the roles of peroxisomal redox homeostasis in adipogenesis and adipocyte metabolism. We provide a framework for understanding redox regulation of peroxisomal functions in adipocytes together with testable hypotheses for developing therapies for obesity and the related metabolic diseases

    Dynamical susceptibility of a near-critical non-conserved order parameter and B2g Raman response in Fe-based superconductors

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    We analyze the dynamical response of a two-dimensional system of itinerant fermions coupled to a scalar boson ϕ\phi, which undergoes a continuous transition towards nematic order with dd-wave form-factor. We consider two cases: (a) when ϕ\phi is a soft collective mode of fermions near a Pomeranchuk instability, and (b) when it is an independent critical degree of freedom, such as a composite spin order parameter near an Ising-nematic transition. In both cases, the order-parameter is not a conserved quantity and the dd-wave fermionic polarization Π(q,Ω)\Pi (q, \Omega) remains finite even at q=0q=0. The polarization Π(0,Ω)\Pi (0, \Omega) has similar behavior in the two cases, but the relations between Π(0,Ω)\Pi (0, \Omega) and the bosonic susceptibility χ(0,Ω)\chi (0, \Omega) are different, leading to different forms of χ(0,Ω)\chi^{\prime \prime} (0, \Omega), as measured by Raman scattering. We compare our results with polarization-resolved Raman data for the Fe-based superconductors FeSe1x_{1-x}Sx_x, NaFe1x_{1-x}Cox_xAs and BaFe2_2As2_2. We argue that the data for FeSe1x_{1-x}Sx_x are well described within Pomeranchuk scenario, while the data for NaFe1x_{1-x}Cox_xAs and BaFe2_2As2_2 are better described within the "independent" scenario involving a composite spin order

    Interventions to slow aging in humans: Are we ready?

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    Early intervention and intensive management of patients with diabetes, cardiorenal, and metabolic diseases

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    Increasing rates of obesity and diabetes have driven corresponding increases in related cardiorenal and metabolic diseases. In many patients, these conditions occur together, further increasing morbidity and mortality risks to the individual. Yet all too often, the risk factors for these disorders are not addressed promptly in clinical practice, leading to irreversible pathologic progression. To address this gap, we convened a Task Force of experts in cardiology, nephrology, endocrinology, and primary care to develop recommendations for early identification and intervention in obesity, diabetes, and other cardiorenal and metabolic diseases. The recommendations include screening and diagnosis, early interventions with lifestyle, and when and how to implement medical therapies. These recommendations are organized into primary and secondary prevention along the continuum from obesity through the metabolic syndrome, prediabetes, diabetes, hypertension, dyslipidemia, nonalcoholic fatty liver disease (NAFLD), atherosclerotic cardiovascular disease (ASCVD) and atrial fibrillation, chronic kidney disease (CKD), and heart failure (HF). The goal of early and intensive intervention is primary prevention of comorbidities or secondary prevention to decrease further worsening of disease and reduce morbidity and mortality. These efforts will reduce clinical inertia and may improve patients\u27 well-being and adherence

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