Optimizing Glass Design: The Role of Computational Wind Engineering & Advanced Numerical Analysis

Wind induced pressure is a major design consideration for glazing design. However, the effects of façade geometry and urban terrain on wind loading are often difficult to quantify without costly and time-consuming wind tunnel testing.  Accurate 3-dimensional data, covering most major cities, is becoming increasingly accessible, and such models are ideal to support numerical modelling of environmental effects on the built environment, especially if such modelling attempts to capture the geometric effects of the cityscape.  A new methodology to assess the effects of wind loads on the structural strength of glass using transient, geometrically non-linear analyses and improved glass failure prediction models is presented.  A description is provided for both the calculation of wind-induced façade loads, and the development and employment of a finite element (FE) solver to model façade performance.&nbsp

The effect of pre-service treatments on the long term properties of 9Cr steels strengthened by boron and nitrogen

Martensitic 9Cr steels have been developed which are strengthened by boron in order to stabilise the microstructure and improve their long-term creep strength. Boron plays a key role in these steels by stabilising the martensitic laths by decreasing the coarsening rate of M23C6 carbides, which act as pinning points in the microstructure. In this work two modified FB2 steel forgings are compared. Both forgings have similar compositions but one underwent an additional remelting process during manufacture. Creep tests showed that this additional processing step resulted in a significant increase in time to failure. In order to investigate the effect of the processing route on microstructural evolution during aging and creep, a range of advanced electron microscopy techniques have been used including ion beam induced secondary electron imaging and High Angle Annular Dark Field (HAADF) imaging in the Scanning Transmission Electron Microscope. These techniques have enabled the particle population characteristics of all the second phase particles (M23C6, Laves phase, BN and MX) to be quantified for materials from both forging processes. These quantitative data have enabled a better understanding of how the processing route affects the microstructural evolution of FB2 steels

Depuration of Macondo (MC-252) Oil Found in Heterotrophic Scleractinian Corals (Tubastrea coccinea and Tubastrea micranthus) on Offshore Oil/Gas Platforms in the Gulf

The impetus for this study began on 8 May 2011, when we noted sporadic mortality of colonies of orange—cup corals, Tubastrea coccinea (Lesson, 1829), and green sun corals, Tubastrea micranthus (Ehrenberg, 1834; Cnidaria, Anthozoa, Scleractinia) among colonies of coral that appeared to be in good health at the GI 90 block platforms. Colonies of T. coccinea which appeared to be healthy displayed markedly less tissue regression and were bright orange in color. The morbid polyps were dark brown or black. The corals were collected, transported to the laboratory, and segregated; healthy—appearing corals were placed in quarantine tanks. After 12 h in quarantine tanks, the coral exudate turned the tank water black and the colonies died within 48 h. After observing this unusual behavior, we decided to document subsequent collection events and analyze the discharged oil to determine its source

Esophageal resection in the ederly

The aging of the population and longer life expectancy entails an increased number of elderly patients with esophageal cancer and benign pathologies referred for surgical treatment. Esophageal cancer is a pathology that mainly involves elderly patients. The aim of this study is to assess the effects of age on the outcome of surgery for esophageal cancer and benign pathologies in patients treated in our departmen

Palliative treatment of malignant esophageal-cardiac stricture in the ederly

The aging of the population and longer life expectancy entails an increased number of elderly patients with esophageal cancer and benign pathologies referred for surgical treatment. Esophageal cancer is a pathology that mainly involves elderly patients. The aim of this study is to assess the effects of age on the outcome of surgery for esophageal cancer and benign pathologies in patients treated in our department

incidence and factors influencing retinal displacement in eyes treated for rhegmatogenous retinal detachment with vitrectomy and gas or silicone oil

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Assessment of body composition in health and disease using bioelectrical impedance analysis (bia) and dual energy x-ray absorptiometry (dxa): A critical overview

The measurement of body composition (BC) represents a valuable tool to assess nutritional status in health and disease. The most used methods to evaluate BC in the clinical practice are based on bicompartment models and measure, directly or indirectly, fat mass (FM) and fat-free mass (FFM). Bioelectrical impedance analysis (BIA) and dual energy X-ray absorptiometry (DXA) (nowadays considered as the reference technique in clinical practice) are extensively used in epidemiological (mainly BIA) and clinical (mainly DXA) settings to evaluate BC. DXA is primarily used for the measurements of bone mineral content (BMC) and density to assess bone health and diagnose osteoporosis in defined anatomical regions (femur and spine). However, total body DXA scans are used to derive a three-compartment BC model, including BMC, FM, and FFM. Both these methods feature some limitations: the accuracy of BIA measurements is reduced when specific predictive equations and standardized measurement protocols are not utilized whereas the limitations of DXA are the safety of repeated measurements (no more than two body scans per year are currently advised), cost, and technical expertise. This review aims to provide useful insights mostly into the use of BC methods in prevention and clinical practice (ambulatory or bedridden patients). We believe that it will stimulate a discussion on the topic and reinvigorate the crucial role of BC evaluation in diagnostic and clinical investigation protocols

CYP17A1 polymorphism c.-362T>C predicts clinical outcome in metastatic castration-resistance prostate cancer patients treated with abiraterone

Background: Abiraterone became a standard hormonal therapy for patients with metastatic castration-resistance prostate cancer (mCRPC). However, patients may experience primary resistance to treatment. To date, few predictive biomarkers of efficacy have been identified. Our aim was to investigate the association between the single nucleotide polymorphism (SNP) c.-362T>C in the CYP17A1 gene, and clinical outcome in mCRPC patients treated with abiraterone. Patients and methods: mCRPC patients candidate to receive abiraterone were enrolled in the present retrospective pharmacogenetic study. Based on a literature selection, CYP17A1 rs2486758 (c.-362T > C) was selected and analysed by real-time PCR on genomic DNA extracted from whole blood. Univariate analysis was performed to test the association between the SNP and treatment-related clinical outcomes. Results: Sixty mCRPC patients were enrolled in the present study. Patients carrying the mutant CYP17A1 c.-362CT/CC genotypes showed a shorter median progression-free survival (PFS) and prostate-specific antigen-PFS (PSA-PFS) compared to patients carrying the TT genotype (10.7 vs 14.2 months and 8 vs 16 months, respectively; p = 0.04). No association between the selected SNP and the overall survival was found. Conclusions: These findings suggest an association between CYP17A1 c.-362T>C polymorphism and poorer clinical outcome with abiraterone for mCRPC patients. However, further validations on larger cohort of patients are needed to confirm its role as a predictive biomarker for abiraterone resistance