Clustering as a criterion for the success of modern industrial enterprises

The paper reveals the problems of the use of clusters as an important factor of innovative development of Russian enterprises and territorial entities delineated a theoretical basis for the existence of territorial formations, showing their relationship with the clusters displayed in the cluster's functioning as an open system. All the more important in the formation of innovation territorial entities in Russia acquire the cluster structure based on cooperation of enterprises, financial institutions, educational institutions etc. In the developed countries have long had and continue to have such structures in various industries. In the works of famous foreign scientists clearly defined theoretical bases of formation and functioning of clusters, use cluster models to ensure the competitiveness of the economy, their advantages and disadvantages. Foreign experience can be useful to develop a national strategy for clustering of Russia, with a comprehensive study of its socioeconomic development. These tasks at this stage be a priority for Central and local public authorities. Issues related to the principles of clusters, innovation economy, have been studied by many scientists, both Russian and foreign. In published works, the essence of cluster analysis, given the definition of "cluster" classification of clusters, the role of innovative development of economy, experience of the use of cluster models, etc

Arctic strategies for socio-economic development of circumpolar states: national and regional aspects

In the presented paper, the authors have revealed some key priorities of the state Arctic policies of circumpolar countries on the base of the analysis of political and programmatic documents. The analysis of political and programmatic documents has shown that the state Arctic policies of the circumpolar countries are focused on expanding external interaction in the Arctic and maintaining the sustainable development of their own Arctic territorie

The impact of retirement age increasing on demographic processes in Russia and its arctic territories

The paper deals with the assessment of the impact of the retirement age increasing on demographic processes in Russia and its Arctic territories. The aim of the research is the consideration of the question whether the effect of the change in the retirement age for Russia on the whole and the Russian Arctic in particular is justified from the standpoint of demographic

PROGNOSTIC VALUE OF pSTAT3 EXPRESSION IN DIFFUSIVE B-LARGE CELL LYMPHOMA IN THE RUSSIAN PATIENT SAMPLE

The aim of the study was to evaluate the prognostic value of pSTAT3 expression in diffuse B-large cell lymphoma (DLBCL) in a Russian sample of patients. Material and methods. Retrospectively, the results of an examination of 50 patients with newly diagnosed DLBCL in the period from 2014 to 2017 were evaluated. Using immunohistochemical and morphometric methods, the relative number of tumor cells expressing pSTAT3 was determined. The relationship of various levels of marker expression with clinical and laboratory parameters was analyzed, and long-term results of patient therapy were evaluated. Results and discussion. The overexpression of pSTAT3 protein is associated with a non-GCB subtype of the disease, an advanced stage, the patients of 60 years and older age, as well as with a lower frequency of achieving complete remissions with DLBCL. Patients with a high degree of marker expression in tumor cells had lower rates of overall (OS) and progressive survival (PFS). It was revealed that the marker under study has good predictive ability, but is not an independent prognosis factor for DLBCL. Conclusions. The level of expression of pSTAT3 is an informative factor that allows predicting the response to standard therapy for diffuse B-large cell lymphoma. The indicated marker may be useful for identifying patients who need individualization of therapeutic tactics for this disease

Anisotropy of polarizability of the silatranes

1. Polarizability parameters have been determined for the Si-C and Si-O bonds. The Si-O bond of the siloxanes does not show axial symmetry. 2. The axes of the molecular polarizability ellipsoid for 1-methylsilatrane have been determined. 3. The transannular N → Si bond shows a pronounced anisotropy of polarizability in the silatranes. © 1977 Plenum Publishing Corporation

Health problems of students in an institution of higher learning

В статье рассмотрены компоненты, влияющие на здоровье студентов в процессе физического воспитания и предложены условия, которые могут осуществляться в образовательном процессе вуза и способствовать решению проблемы формирования ЗОЖ студентаThis article describes the components that affect the health of students in physical education and proposed conditions, which can be implemented in the educational process of the university and contribute to solving the problem of forming HLS studen

Influence of the child's genotype features on the course and prognosis of essential arterial hypertension. Clinical case

Clinical case of early diagnostics of essential arterial hypertension in a 6-year-old child, which is described in the article, shows that comprehensive medical examination in patients with persistent high blood pressure is required. Identification of genetic polymorphisms of arterial hypertension should be done to exclude secondary hypertension and define possible reasons for resistance to drug therapy and prognosis for the disease.На клиническом примере раннего дебюта эссенциальной артериальной гипертензии (АГ) у шестилетнего ребенка показана необходимость комплексного обследования пациентов со стойко повышенным артериальным давлением, включая генетическое обследование на полиморфизм генов АГ, позволяющего исключить вторичный генез артериальной гипертензии, определить вероятные причины резистентности к проводимой терапии и прогноз течения заболевания

Russia and the Arab Spring: supporting the counter-revolution

Russia’s response to the Arab Spring ranged from apprehension to deep anxiety and diverged significantly from the US and the EU responses. While initially welcoming the popular demands for political reform in North Africa, the Russian reaction rapidly became more critical as a result of Western military intervention into Libya and the threat of the spread of Islamist extremism. It was these twin fears which prompted the Russian leadership to adopt an uncompromizing stance towards Syria. While geopolitical factors certainly played a role in driving Russian strategy, domestic political factors were also more significant. As the Russian leadership felt internally threatened by the growing opposition within the country, conflict in the Middle East highlighted the perceived flaws of the imposition of Western liberal democracy and the virtues of Russia’s own model of state-managed political order. There was, as such, a significant ideational and ideological dimension to the Russian response to the Arab Spring

Значение экспрессии рАКТ1 при диффузной В-крупноклеточной лимфоме

Aim. To evaluate the prognostic value of pAKT1 expression by tumor cells in patients with diffuse large B-cell lymphoma.Materials and methods. The study included 90 patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL), who were treated at the clinic of Kirov Research Institute of Hematology and Blood Transfusion from 2014 to 2017 and received standard first-line polychemotherapy according to the R-CHOP regimen. Using immunohistochemical and morphometric methods, the relative number of tumor cells expressing pAKT1 was determined. Using the two-sided Fisher’s exact test, the relationship of different levels of marker expression with clinical and laboratory parameters of patients and long-term treatment results was analyzed. The impact of pAKT1 on the risk of an adverse event was assessed using the Cox regression analysis.Results. Overexpression of pAKT1 is associated with unfavorable clinical characteristics of patients with DLBCL, excessive expression of the BCL2 and c-Myc oncoproteins, as well as with low rates of overall and progressive survival. Overexpression of pAKT1 is an independent prognostic factor and statistically significantly affects the risk of an adverse outcome in DLBCL.Conclusion. The degree of pAKT1 expression is an informative criterion that allows to predict the course of diffuse large B-cell lymphoma. It is advisable to use the indicated marker when stratifying patients into risk groups.Цель – оценить прогностическое значение экспрессии рАКТ1 опухолевыми клетками у больных диффузной В-крупноклеточной лимфомой.Материалы и методы. В исследование включены 90 пациентов с впервые диагностированной диффузной В-крупноклеточной лимфомой (ДВККЛ), наблюдавшиеся в клинике института с 2014 по 2017 г. и получавшие стандартную полихимиотерапию первой линии по схеме R-CHOP. С помощью иммуногистохимического и морфометрического методов определено относительное количество экспрессирующих рАКТ1 опухолевых клеток. С помощью точного двухстороннего критерия Фишера проанализирована взаимосвязь различных уровней экспрессии маркера с клинико-лабораторными показателями пациентов и отдаленными результатами лечения. Оценку влияния рАКТ1 на риск наступления неблагоприятного события проводили с помощью регрессионного анализа Кокса.Результаты. Гиперэкспрессия рАКТ1 ассоциирована с неблагоприятными клиническими характеристиками больных диффузной В-крупноклеточной лимфомой, избыточной экспрессией онкобелков BCL2, cMyc, а также низкими показателями общей и беспрогрессивной выживаемости. Гиперэкспрессия рАКТ1 является независимым фактором прогноза и статистически значимо влияет на риск возникновения неблагоприятного исхода при ДВККЛ.Заключение. Степень экспрессии рАКТ1 является информативным критерием, позволяющим прогнозировать течение диффузной В-крупноклеточной лимфомы. Указанный маркер целесообразно использовать при стратификации пациентов на группы риска

СОВРЕМЕННЫЕ АСПЕКТЫ ПРОФИЛАКТИКИ ПЕРИНАТАЛЬНОЙ ПЕРЕДАЧИ ВИЧ В САНКТ-ПЕТЕРБУРГЕ

Saint-Petersburg is among the leaders in medical treatment of HIV-positive pregnant women and their children. The joint efforts of AIDS Center, women’s consultation clinics, and maternity hospitals ensure the low rate of mother-tochild HIV transmission (1.3 % in 2007). The article reviews some advances as well as problems related to the medical treatment of HIV-positive pregnant women. The analysis of those issues will contribute to creation of a better healthcare system for pregnant women, will raise the awarness of how important medical monitroting and preventive care are and will favour further reduction of mother-to child transmission.Санкт-Петербург занимает лидирующие позиции в оказании помощи ВИЧ-инфицированным беременным женщинам и их детям. Совместные усилия специалистов Центра СПИД, женских консультаций, родовспомогательных учреждений обеспечивают низкую часто- ту перинатальной передачи ВИЧ (1,3% в 2017 г.). В статье отмечены успехи и некоторые проблемы в оказании помощи ВИЧ-инфицированным беременным женщинам, анализ которых будет способствовать улучшению организации помощи при беременности, повышению приверженности к наблюдению и профилактике, дальнейшему снижению числа детей с перинатальным путем заражения