Properties of Galaxies in and around Voids

Two surveys for intrinsically faint galaxies towards nearby voids have been conducted at the MPI f\"ur Astronomie, Heidelberg. One selected targets from a new diameter limited ($\Phi \ge 5''$) catalog with morphological criteria while the other used digitized objective prism Schmidt plates to select mainly HII dwarf galaxies. For some 450 galaxies, redshifts and other optical data were obtained. We studied the spatial distribution of the sample objects, their luminosity function, and their intrinsic properties. Most of the galaxies belong to already well known sheets and filaments. But we found about a dozen highly isolated galaxies in each sample (nearest neighborhood distance $\ge 3 h_{75}^{-1} Mpc$). These tend to populate additional structures and are not distributed homogeneously throughout the voids. As our results on 'void galaxies' still suffer from small sample statistics, I also tried to combine similar existing surveys of nearby voids to get further hints on the larger structure and on the luminosity function of the isolated galaxies. No differences in the luminosity function of sheet and void galaxies could be found. The optical and infrared properties of both samples are in the normal range for samples dominated by late-type dwarfs. Follow-up HI studies show that the isolated dwarfs in both samples have unusual high amount of neutral gas for a given luminosity.Comment: 10 pages, 4 figures, latex, to appear in the proceedings of the 'Ringberg workshop on Large Scale Structure', hold Sep. 23-28, 199

Genetic defects in common variable immunodeficiency

Common variable immunodeficiency (CVID) is the most frequent clinically manifested primary immunodeficiency. According to clinical and laboratory findings, CVID is a heterogeneous group of diseases. Recently, the defects of molecules regulating activation and terminal differentiation of B lymphocytes have been described in some patients with CVID. In this study, we show the overview of deficiencies of inducible costimulator, transmembrane activator and calcium-modulator and cytophilin ligand interactor, CD19 molecules, their genetic basis, pathogenesis and clinical manifestations

BAFF- and TACI-Dependent Processing of BAFFR by ADAM Proteases Regulates the Survival of B Cells.

B cell activating factor (BAFF) provides B cells with essential survival signals. It binds to three receptors: BAFFR, TACI, and BCMA that are differentially expressed by B cell subsets. BAFFR is early expressed in circulating B cells and provides key signals for further maturation. Here, we report that highly regulated BAFFR processing events modulate BAFF responses. BAFFR processing is triggered by BAFF binding in B cells co-expressing TACI and it is executed by the metalloproteases ADAM10 and ADAM17. The degree of BAFF oligomerization, the expression of ADAM proteins in different B cell subsets, and the activation status of the cell determine the proteases involved in BAFFR processing. Inhibition of ADAM10 augments BAFF-dependent survival of primary human B cells, whereas inhibition of ADAM17 increases BAFFR expression levels on germinal center B cells. Therefore, BAFF-induced processing of BAFFR regulates BAFF-mediated B cell responses in a TACI-dependent manner

The Hamburg/SAO survey for emission-line galaxies. VI. The sixth list of 126 galaxies

We present the sixth list with results of the Hamburg/SAO Survey for Emission-Line Galaxies. The final list resulted from follow-up spectroscopy conducted with the 4.5m MMT telescope in 1996, and with 2.2m CAHA and 6m SAO telescopes in 2000 to 2003. The data of this snap-shot spectroscopy survey confirmed 134 emission-line objects out of 182 observed candidates and allowed their quantitative spectral classification and redshift determination. We classify 73 emission-line objects as definite or probable blue compact or HII galaxies (BCG), 8 as QSOs, 4 as Seyfert 1 and 2 galaxies. 30 low-excitation objects were classified as definite or probable starburst nuclei (SBN), 3 as dwarf amorphous nuclei starburst galaxies (DANS) and 2 as LINERs. Due to the low signal-to-noise ratio we could not classify 14 ELGs (NON). For another 9 galaxies we did not detect any significant emission lines. For 98 emission-line galaxies, the redshifts and/or line intensities are determined for the first time. For the remaining 28 previously-known ELGs we give either improved data the line intensities or some independent measurements. The detection rate of ELGs is ~70%. This paper completes the classification of strong-lined ELGs found in the zone of the Hamburg/SAO survey. Together with previously known BCG/HII galaxies in this zone, this sample of ~500 objects is the largest to date in a well bound region.Comment: 18 pages, including 8 tables and 1 figure. Plots of the spectra of 126 ELGs are in a separate 13-page Appendix. Accepted for publication in Astron.Astrophys. Full paper with full-resolution figures is available at http://www.eso.org/~akniaze

HS 2134+0400 - new very metal-poor galaxy, a representative of void population?

We present the SAO 6m telescope spectroscopy of a blue compact galaxy (BCG) HS 2134+0400 discovered in frame of the dedicated Hamburg/SAO survey for Low Metallicity BCGs (HSS-LM). Its very low abundance of oxygen (12+log(O/H) = 7.44), as well as other heavy elements (S, N, Ne, Ar), assigns this dwarf galaxy to the group of BCGs with the lowest metal content. There are only eight that low metallicity among several thousand known BCGs in the nearby Universe. The abundance ratios for the heavy elements (S/O, Ne/O, N/O, and Ar/O) are well consistent with the typical values of other very metal-poor BCGs. The global environment of HS 2134+0400 is atypical of the majority of BCGs. The object falls within the Pegasus void, the large volume with the very low density of galaxies with the normal (M_B* = -19.6) or high luminosity. Since we found in voids a dozen more the very metal-poor galaxies, we discuss the hypothesis that such objects can be representative of a substantial fraction of the void dwarf galaxy population.Comment: 6 pages, including 2 tables and 2 postscript figures. Submitted to Astronomy Letter

A Spectroscopic Study of a Large Sample of Wolf-Rayet Galaxies

We analyze long-slit spectral observations of 39 Wolf-Rayet (WR) galaxies with heavy element mass fraction ranging over 2 orders of magnitude, from Zsun/50 to 2Zsun. Nearly all galaxies in our sample show broad WR emission in the blue region of the spectrum (the blue bump) consisting of an unresolved blend of N III 4640, C III 4650, C IV 4658 and He II 4686 emission lines. Broad C IV 5808 emission (the red bump) is detected in 30 galaxies. Additionally, weaker WR emission lines are identified, most often the N III 4512 and Si III 4565 lines, which have very rarely or never been seen and discussed before in WR galaxies. These emission features are characteristic of WN7-WN8 and WN9-WN11 stars respectively. We derive the numbers of early WC (WCE) and late WN (WNL) stars from the luminosities of the red and blue bumps, and the number of O stars from the luminosity of the Hbeta emission line. Additionally, we propose a new technique for deriving the numbers of WNL stars from the N III 4512 and Si III 4565 emission lines. This technique is potentially more precise than the blue bump method because it does not suffer from contamination of WCE and early WN (WNE) stars and nebular gaseous emission. The N(WR)/N(O+WR) ratio decreases with decreasing metallicity, in agreement with predictions of evolutionary synthesis models. The N(WC)/N(WN) ratios and the equivalent widths of the blue bump EW(4650) and of the red bump EW(5808) derived from observations are also in satisfactory agreement with theoretical predictions.Comment: 49 pages, 9 figures, to appear in Astrophys.

The Hamburg/SAO Survey for Emission--Line Galaxies. V. The Fifth List of 161 Galaxies

We present the fifth list with results of the Hamburg/SAO Survey for Emission-Line Galaxies (HSS therein, SAO -- Special Astrophysical Observatory, Russia). The list is a result of follow-up spectroscopy conducted with the 2.2m CAHA and 4m Kitt Peak telescopes in 1999. The data of this snap-shot spectroscopy survey confirmed 166 emission-line objects out of 209 observed candidates and allowed their quantitative spectral classification and redshift determination. We could classify 98 emission-line objects as BCG/HII galaxies or probable BCGs, 5 -- as QSOs, 3 - as Seyfert galaxies, 2 - as super-associations in subluminous spiral galaxies. 25 low-excitation objects were classified as starburst nuclei (SBN), 24 as dwarf amorphous nuclei starburst galaxies (DANS) and 3 as LINERs. Due to low signal-to-noise ratio we could not classify 6 ELGs. Furthermore, for another 4 galaxies we did not detect any significant emission lines. For 131 emission-line galaxies, the redshifts and/or line intensities are determined for the first time. For the remaining 30 previously known ELGs we give either improved data of the line intensities or some independent measurements.Comment: 18 pages, A&A in press. Figures A1-A17 (spectra) available in GIF-format. PS-file with Figures A1-A17 available via http://precise.sao.ru/Laboratory/Publications/2001/HSSV_figs.ps.g