Wandering voices: Refrain citation in thirteenth-century French music and poetry

Cited refrains wandered through nearly every thirteenth-century French musical and poetic genre, connecting and disrupting works. These refrains have long been viewed as central to poetic practice, creating productive tensions between lyric and narrative poetry, evidencing the orality behind many medieval texts, and articulating social difference by mixing poetic registers. This dissertation resituates refrain citation within a rich context of medieval reading and writing practices, as well as crucial notions of auctoritas, or the use of citation to create authority in medieval literature. It offers a new view of the refrain as a vital part of these strategies of authorization: a tradition typified by the Roman de la Rose. Refrain citation is not only a technique but a repertory as well. Assembling the families of musical and poetic works that are connected through refrain citation is a necessary starting point. In taking on the long-established idea that refrains are representations of an oral song culture, I offer the first comprehensive account of their musical transmission and establish that the practice of refrain citation is in fact writerly. Understanding the refrain as writing suggests different interpretive strategies than those that have been employed to date. Music-compositional analysis shows that composers treated refrains as borrowed musical material. The medieval traditions of rhetoric and hermeneutics suggest a reception history for the refrain, showing a variety of ways in which medieval listeners and readers might have interpreted refrain citations in their musical and literary contexts. Finally, thirteenth-century composer Adam de la Halle provides an important case study, demonstrating the connection between refrain citation and authority. Instead of citing earlier, authoritative writers, Adam de la Halle begins to cite refrains from his own musical compositions, a gesture through which he positions himself as a vernacular auctor. By bringing music into dialogue with writing traditions, this dissertation suggests the rich interdependence of the sung and the written in medieval culture and the slippage between these categories. My findings move toward an alternative history of authorship in thirteenth-century France, one forged through cited song

Wandering voices: Refrain citation in thirteenth-century French music and poetry

Cited refrains wandered through nearly every thirteenth-century French musical and poetic genre, connecting and disrupting works. These refrains have long been viewed as central to poetic practice, creating productive tensions between lyric and narrative poetry, evidencing the orality behind many medieval texts, and articulating social difference by mixing poetic registers. This dissertation resituates refrain citation within a rich context of medieval reading and writing practices, as well as crucial notions of auctoritas, or the use of citation to create authority in medieval literature. It offers a new view of the refrain as a vital part of these strategies of authorization: a tradition typified by the Roman de la Rose. Refrain citation is not only a technique but a repertory as well. Assembling the families of musical and poetic works that are connected through refrain citation is a necessary starting point. In taking on the long-established idea that refrains are representations of an oral song culture, I offer the first comprehensive account of their musical transmission and establish that the practice of refrain citation is in fact writerly. Understanding the refrain as writing suggests different interpretive strategies than those that have been employed to date. Music-compositional analysis shows that composers treated refrains as borrowed musical material. The medieval traditions of rhetoric and hermeneutics suggest a reception history for the refrain, showing a variety of ways in which medieval listeners and readers might have interpreted refrain citations in their musical and literary contexts. Finally, thirteenth-century composer Adam de la Halle provides an important case study, demonstrating the connection between refrain citation and authority. Instead of citing earlier, authoritative writers, Adam de la Halle begins to cite refrains from his own musical compositions, a gesture through which he positions himself as a vernacular auctor. By bringing music into dialogue with writing traditions, this dissertation suggests the rich interdependence of the sung and the written in medieval culture and the slippage between these categories. My findings move toward an alternative history of authorship in thirteenth-century France, one forged through cited song

CREST: Phase III study of sasanlimab and BCG for patients with BCG-naïve high-risk non-muscle-invasive bladder cancer - supplementary material

Supplementary video </p

CREST: Phase III study of sasanlimab and BCG for patients with BCG-naïve high-risk non-muscle-invasive bladder cancer - supplementary material

Supplementary PLSP</p

Primary Chemoablation of Low-Grade Intermediate-Risk Non-Muscle-Invasive Bladder Cancer Using UGN-102, A Mitomycin-Containing Reverse Thermal Gel (Optima II): A Phase 2b, Open-Label, Single-Arm Trial.

PURPOSE: Low-grade intermediate-risk non-muscle-invasive bladder cancer (LG IR NMIBC) is a recurrent disease, thus requiring repeated transurethral resection of bladder tumors (TURBT) under general anesthesia. We evaluated the efficacy and safety of UGN-102, a mitomycin-containing reverse thermal gel, as a primary chemoablative therapeutic alternative to TURBT for patients with LG IR NMIBC. MATERIALS AND METHODS: This prospective, Phase 2b, open-label, single-arm trial recruited patients with biopsy-proven LG IR NMIBC to receive 6 once-weekly instillations of UGN-102. The primary endpoint was complete response (CR) rate, defined as the proportion of patients with negative endoscopic examination, negative cytology, and negative for-cause biopsy 3 months after treatment initiation. Patients with CR were followed quarterly up to 12 months to assess durability of treatment effect. Safety and adverse events were monitored throughout the trial. RESULTS: Sixty-three patients (38 males, 25 females, 33-96 years) enrolled and received ≥1 instillation of UGN-102. Forty-one (65%) achieved CR at 3 months, of whom 39 (95%), 30 (73%), and 25 (61%) remained disease-free at 6, 9, and 12 months after treatment initiation, respectively; 13 patients had documented recurrences. The probability of durable response 9 months after CR (12 months after treatment initiation) was estimated to be 73% by Kaplan-Meier analysis. Common adverse events (incidence ≥10%) included dysuria, urinary frequency, hematuria, micturition urgency, urinary tract infection, and fatigue. CONCLUSIONS: Nonsurgical primary chemoablation of LG IR NMIBC using UGN-102 resulted in significant treatment response with sustained durability. UGN-102 may provide an alternative to repetitive surgery for patients with LG IR NMIBC