Sally Carter to Mr. Meredith (1 October 1962)

https://egrove.olemiss.edu/mercorr_pro/1310/thumbnail.jp

Mechanisms of photoprotection by 20-hydroxyvitamin D3, a naturally occurring 1a25-dihydroxyvitamin D3 analogue

The mechanism of the photoprotection byve effect of the active metabolite of vitamin D3, 1, 25 dihydroxyvitamin D (1,25(OH)2D) against UVR-induced DNA damage and immunosuppression is not completely understood. It has been shown that vitamin D-like compounds and analogues are similarly photoprotective without inducing hypercalcaemic toxicity and that photoprotection from UVR is affected by gender. The aim of the study was to test whether 20(OH)D, a CYP11A1biological metabolite of 1,25(OH)2D and tetrahydrocurcumin (THC), a vitamin D like compound, would reduce UVR-induced DNA damage in primary human keratinocytes and Skh:Hr1 mice, and inflammatory oedema and immune suppression in Skh:Hr1 mice. The mechanism of photoprotection by 1,25(OH)2D and 20(OH)D was tested using inhibitors of the Wnt signalling pathway (IWR-1) and chloride channels (DIDS). The influence of gender on photoprotection against DNA damage and immunosuppression was assessed using Skh:Hr1 mice and oestrogen receptor- knock out (ERβKO) mice. 20(OH)D and THC were as photoprotective as 1,25(OH)2D against UVR-induced DNA damage in vitro and in vivo 3 hours following UVR exposure. In primary human keratinocytes, DIDS reversed the protective effect of 1,25(OH)2D and 20(OH)D against UVR-induced DNA damage. IWR-1 alone was protective against UVR-induced DNA damage, and did not cause reversal of photoprotection by 1,25(OH)2D and 20(OH)D. 20(OH)D was as effective as 1,25(OH)2D in reducing UVR-induced skin inflammation and immunosuppression in Skh:Hr1 mice. UVR-induced immunosuppression and DNA damage was greater in males than females. ERβKO mice were more susceptible to UVR-induced immunosuppression than wild type controls and the photoprotective effect of 1,25(OH)2D and 20(OH)D was reduced. This study showed that that 20(OH)D is photoprotective against UVR-induced DNA damage, inflammation and immunosuppression in a non-genomic manner, and demonstrated a potential interaction between ERβ and the actions of VDR ligands in photoprotection

'Sounds of Intent' : Mapping musical behaviour and development in children and young people with complex needs

This article reports on the first year of an Esmae Fairbairn Foundation-funded research project into the design and evaluation of an original 'framework' for mapping the behaviour and development in, and through, music for children with complex needs, specifically those with profound and multiple learning difficulties (PMLD). An initial four-month design and pilot phase critiqued and evaluated a framework that was grounded in video-based iterative analyses of individual case studies that had been collected during the previous two years. The piloting phase was followed by a sustained period of classroom-based music lesson observation in five special schools over a period of seven months. A total of 630 observations were made using the framework for 68 participants whose ages ranged from 4 years 7 months to 19 years 1 month. Subsequent analyses support the general design features of the observational framework and provide new evidence of PMLD musical behaviour and development

DSM and cultural diversity

Abstract presented at The 14th Pacific Rim College of Psychiatrists Scientific Meeting, 28-30 October 2010, Brisbane, Australi

Results for the 2023 VIMS Industry Cooperative Surveys of the Mid-Atlantic Bight and Georges Bank Scallop Resource Areas

The Virginia Institute of Marine Science (VIMS) conducted high resolution sea scallop dredge surveys of the Mid-Atlantic Bight (MAB) and Georges Bank (GB) scallop resource areas during May–July 2023

Standards for quality assurance of pre-employment medical examinations of seafarers: the IMHA Quality experience

Standards to assess the quality of doctors and clinics performing pre-employment medical examinations (PEMEs) were developed for International Maritime Health Association (IMHA) Quality, a not for profit organisation, created to provide an ethically sound and professional accepted accreditation system that would benefit seafarers having PEMEs and employers, insurers and national maritime authorities seeking valid assessments of seafarers’ fitness for duty. These standards followed a format widely used in other healthcare settings, where assessment of clinical performance is desirable. Uptake of these standards by doctors and clinics was not as expected, as they did not see sufficient business benefits coming from accreditation to justify the costs. This was, at least in part, because there was some antagonism to a professionally based accreditation system from commercial interest groups such as insurers, while national maritime authorities did not come forward to use the system as a recommendation or requirement for approval of doctors. The IMHA Quality accreditation system has now been closed and for this reason we are making the standards publicly available. Those who helped to develop them hope that doctors and clinics will now use them as a means of improving the quality of their practice when performing PEME

Design of the Cruise and Flap Airfoil for the X-57 Maxwell Distributed Electric Propulsion Aircraft

A computational and design study on an airfoil and high-lift flap for the X-57 Maxwell Distributed Electric Propulsion (DEP) testbed aircraft was conducted. The aircraft wing sizing study resulted in a wing area of 66.67 sq ft and aspect ratio of 15 with a design requirement of V(stall) = 58 KEAS, at a gross weight of 3,000 lb. To meet this goal an aircraft C(L,max) of 4.0 was required. The design cruise condition is 150 KTAS at 8,000 ft. This resulted in airfoil requirements of c(l) is approximately 0.90 for the cruise condition at Re = 2.35 x 10 (exp 6). A flapped airfoil with a c(l,max) of approximately 2.5 or greater, at Re = 1.0 x 10 (exp 6), was needed to have enough lift to meet the stall requirement with the DEP system. MSES computational analyses were conducted on the GAW-1, GAW-2, and the NACA 5415 airfoil sections, however they had limitations in either high drag or low c(l,max) on the cruise airfoil, which was the impetus for a new design. A design was conducted to develop a low drag airfoil for the X-57 cruise conditions with high c(l,max). The final design was the GNEW5BP93B airfoil with a minimum drag coefficient of c(d) = 0.0053 at c(l) = 0.90 and achieved laminar flow back to 69% chord on the upper surface and 62% chord on the lower surface. With fully turbulent flow, the drag increases to c(d) = 0.0120. The predicted maximum lift with turbulent flow is a c(l,max) of 1.95 at alpha = 19 deg. The airfoil is characterized by relatively flat pressure gradient regions on both surfaces at alpha = 0 deg, and aft camber to get extra lift out of the lower surface concave region. A 25% chord slotted flap was designed and analyzed with MSES for a 30 deg flap deflection. Additional 30 deg and 40 deg flap deflection analyses for two flap positions were conducted with USM3D using several turbulence models, for two angles of attack, to assess near c(l,max) with varied flap position. The maximum c(l) varied between 2.41 and 3.35. An infinite-span powered high-lift study was conducted on a GAW-1 constant chord 40 deg flapped airfoil section with FUN3D to quantify the airfoil lift increment that can be expected from a DEP system. The 16.7 hp/propeller blown wing increases the maximum C(L) from 3.45 to C(L) = 6.43, which is an effective q ratio of 1.86. This indicates that if the unblown high-lift flapped airfoil of the X-57 airplane achieves a c(l,max) of 2.78, then the high-lift augmentation blowing could yield a sectional lift coefficient of approximately 4.95 at c(l,max). Finally, a computational study was conducted with FUN3D on an infinite-span constant chord GAW-1 cruise airfoil to determine the impact of high-lift propeller diameter to wing chord ratio on the lift increment of the DEP system. A constant diameter propeller and nacelle size were used in the study. Three computational grids were made with airfoil chords of 0.5*chord, 1.0*chord, and 2.0*chord. Results of the propeller diameter to wing chord ratio study indicated that the blown to unblown C(L) ratio increased as the chord was decreased. However, because of the increase in relative size of the high-lift nacelle to the wing, which impacted wing lift performance, the study indicated that a propeller diameter to wing chord ratio of 1.0 gives the overall best maximum lift on the wing with the DEP system

HCI goes to the zoo

This workshop will explore research into interactive and digital technologies in zoos, aquariums and wildlife parks. Such sites are making increasing use of technology in their work to foster educational, emotional and entertaining connections between visitors and animals, with the goal of transforming attitudes to wildlife and conservation. Bringing together HCI researchers with interests in zoos (as a design context) and animals (as a design user), as well as animal welfare and behavior experts, this workshop will further our understanding of what it means to design and use technology in this space at the intersection of the human and animal worlds

Screening for Social Determinants of Health in Children with Attention-Deficit/Hyperactivity Disorder

Purpose/Background Increased social determinants of health (SDoH) are associated with poorer health outcomes and decreased treatment compliance. Addressing SDoH can be associated with increased treatment compliance, although currently there is no standard for completing SDoH screening. The WE CARE screening tool is a validated screen that asks about 6 SDoH and whether the family is interested in assistance if the screen is positive. The purpose of this project was to implement the use of the WE CARE screening tool for patients with attention deficit hyperactivity disorder (ADHD) at follow-up visits. Methods From October 17, 2022 through November 22, 2022, charts were reviewed for patients scheduled with the participating nurse practitioner and physicians who met inclusion criteria. The WE CARE screening tool was administered and reviewed by the provider, then a referral to social work could be initiated if needed. Results Following chart review, 23 patients met eligibility criteria, and of these 12 (52%) completed a WE CARE form. Needs were identified on 2 of the completed forms (17 %), and no referrals were made to social work. Implications for Nursing Practice During the implementation period of this quality improvement project, only about half of eligible families had a screening form completed, either because the parent refused or because the physician or nurse practitioner forgot to give the form to the family. Based on the results of this initial implementation phase, more information is needed from the participating healthcare providers about whether they did not feel comfortable using the screen, thought the screen was helpful, or if there were other factors impacting the rate of form completion. It may also be helpful to try to use this screening tool with new patients first instead of follow-ups. The results of the current project do not yet support a change in practice by implementing this tool