Overresolving in the Laplace domain for convolution quadrature methods

Convolution quadrature (CQ) methods have enjoyed tremendous interest in recent years as an efficient tool for solving time-domain wave problems in unbounded domains via boundary integral equation techniques. In this paper we consider CQ type formulations for the parallel space-time evaluation of multistep or stiffly accurate Runge--Kutta rules for the wave equation. In particular, we decouple the number of Laplace domain solves from the number of time steps. This allows us to overresolve in the Laplace domain by computing more Laplace domain solutions than there are time steps. We use techniques from complex approximation theory to analyze the error of the CQ approximation of the underlying time-stepping rule when overresolving in the Laplace domain and show that the performance is intimately linked to the location of the poles of the solution operator. Several examples using boundary integral equation formulations in the Laplace domain are presented to illustrate the main results. Read More: http://epubs.siam.org/doi/10.1137/16M106474

Single observable concurrence measurement without simultaneous copies

We present a protocol that allows us to obtain the concurrence of any two qubit pure state by performing a minimal and optimal tomography of one of the subsystems through measuring a single observable of an ancillary four dimensional qudit. An implementation for a system of trapped ions is also proposed, which can be achieved with present day experimental techniques.Comment: 4 pages, 1 figur

Post-translational modifications of lipid-activated nuclear receptors: Focus on metabolism

Post-translational modifications (PTM) occur to nearly all proteins, are catalysed by specific enzymes and are subjected to tight regulation. They have been shown to be a powerful means by which the function of proteins can be modified resulting in diverse effects. Technological advances such as the increased sensitivity of mass spectrometry-based techniques and availability of mutant animal models have enhanced our understanding of the complexities of their regulation and the effect they have on protein function. However, the role that PTMs have in a pathological context still remains unknown for the most part. PTMs enable the modulation of nuclear receptor function in a rapid and reversible manner in response to varied stimuli, thereby dramatically altering their activity in some cases. This review will focus on acetylation, phosphorylation, sumoylation and O-GlcNAcylation, which are the four most studied PTMs affecting lipid-regulated nuclear receptor biology, and the implications of such modifications on metabolic pathways under homeostatic and pathological situations. Moreover, we review recent studies on the modulation of PTMs as therapeutic targets for metabolic diseases

Reptiles, Squamata, Parque Natural Municipal da Taquara, municipality of Duque de Caxias, state of Rio de Janeiro, Southeastern Brazil

Herein we report a list of the reptiles from Parque Natural Municipal da Taquara, municipality of Duque deCaxias, state of Rio de Janeiro, southeastern Brazil, an area situated in the Atlantic Rainforest Domain. The study wascarried out from September 2006 to October 2008. We recorded 31 species of Squamate reptiles: one species of thefamily Amphisbaenidae; eight species of lizards of the families Anguidae (n = 1), Gekkonidae (1), Phyllodactylidae (1),Polychrotidae (1), Scincidae (1), Teiidae (2), and Tropiduridae (1); and 22 species of snakes of the families Boidae (2),Colubridae (6), Dipsadidae (11), Elapidae (1), and Viperidae (2). Our study indicates that the PNMT is an important area forthe conservation of the Squamate reptile assemblages that inhabit lowlands of Atlantic Rainforest in Brazil

Relationships and events: towards a general theory of reification and truthmaking.

We propose a novel ontological analysis of relations and relationships based on a re-visitation of a classic problem in the practice of knowledge repre- sentation and conceptual modeling, namely relationship reification. Our idea is that a relation holds in virtue of a relationship's existence. Relationships are therefore truthmakers of relations. In this paper we present a general theory or reification and truthmaking, and discuss the interplay between events and rela- tionships, suggesting that relationships are the focus of events, which emerge from the context (the scene) they occur in

Características reprodutivas de ovelhas Santa Inês cruzadas com reprodutores Dorper e Somalis brasileira.

Os cruzamentos na ovinocultura tornaram-se um importante instrumento para aumentar a velocidade de crescimento dos animais e incrementar os parâmetros reprodutivo, sendo justificadas as pesquisas que gere tecnologias. Objetivou-se, com o presente trabalho, comparar a prolificidade e a fertilidade, de ovelhas Santa Inês (SI) cruzados com as raças Dorper (DP) e Somalis Brasileira (SB). A pesquisa foi conduzida no Campo Experimental Pedro Arle, da Embrapa Tabuleiros Costeiros/SE. Foram utilizadas 95 ovelhas da raça SI com idade variando de dois a sete anos e peso médio de 45,3 kg, criadas em regime semi-intensivo. As fêmeas foram inseminadas por laparoscopia (IL) com sêmen congelado de dois reprodutores das raças DP, SB e SI, formando assim três grupos genéticos: GG1 : SI x SI, GG2 : DP x SI e GG3 : SB x SI. Observou-se que não houve associação entre taxa de fertilidade ao parto e o tipo de acasalamento, obtendo-se taxa média de 43,16 %. A prolificidade média foi de 1,19, não apresentando diferença significativa (P>0,05) entre grupos genéticos. Com base nos resultados, conclui-se que as ovelhas SI apresentaram razoável taxa de fertilidade ao parto, quando submetidas à Inseminação Artificial Laparoscópica em nível de campo, com indução do estro apenas pelo efeito macho; o efeito da heterose sobre a prolificidade pode ser desprezível. Reproductive characteristics of sheep Santa Inês crossed with reproducers Dorper and Somalis Brasileira. Abstract - Interbreedings from the sheep raising become an important means to increase the rapidity of animals growth and even increase reproductive parameters, the searches have been justified for the technological. Advanced development the actual performance considered to confer the prolification and the fertility sheep Santa Snês breed (SI) interbred with the Dorper (DP) and Somalis Brazilian breeds (SB). The search was conduced at experimental rural rustic camp denominated Pedro Arle, to belong to Embrapa Tabuleiros Costeiros/SE. It were utilized ninety five sheeps of the SI breed with age between from two to seven ages and 45,3 medium weight, they were breeding in a half-active regime. The females were inseminated by laparoscopia ( IL) with frozen semen that belongs reproducers of the DP, SB and SI breeds, producing in this manner three genetical groups: GG1: SI x SI, GG2: DP x SI and GG3: SB x SI. So it was understood that there wasn´t any association between the fertility parturition rate in comparison to mating type, obtaining consequently a medium rate of 43,16 %. The prolification average was 1,19, it didn´t present any significative diference ( p>0,05) among to geneticals groups. Basing at these results, it has been concluded that the SI sheeps showed reasonable fertlility rate for the artificial insemination laparoscopic in search level, with induction oestrum only by effect male animal; contrasting the heterose effect and prolification can be worthless

Flavonoids and other compounds from Ouratea ferruginea (Ochnaceae) as anticancer and chemopreventive agents.

The chemical study of the extracts from leaves and stems of Ouratea ferruginea allowed the identification of a new isoflavone, 5-hydroxy-7,3′4′5′-tetramethoxyisoflavone, and twenty two known compounds, including friedelin, 3β-friedelinol, lupeone, a mixture of sitosterol, stigmasterol and campesterol, sitosteryl- and stigmasteryl-3-O-b-D-glucopyranosides, 5,4′-dihydroxy-7,5′,3′-trimethoxyisoflavone, 5,4′-dihydroxy-7,3′-di-methoxyisoflavone (7,3′-di-O-methylorobol), 5,7,4′-trihydroxy-3′,5′-dimethoxyisoflavone (piscigenin), 2R,3R-epicatechin, syringic acid, 2,6-dimethoxybenzoquinone, 2,6-dimethoxyhydroquinone, syringic and ferulic aldehyde, a mixture of vanillic acid, 1-hydroxy-2-methoxy-4-(1E-3-hydroxy-1-propenyl)-benzene and 3,5-dimethoxy-4-hydroxy-dihydrocinamaldehyde, besides amenthoflavone and 7-O-methylamenthoflavone (sequoiaflavone) which are considered as chemotaxonomic markers of Ouratea. The structures were identified by IR, 1H- and 13C-NMR and GC-MS, HPLC-MS, besides comparison with literature data. The inhibitory effects of 5,4′-dihydroxy-7,5′,3′-trimethoxyisoflavone, 7,3′-di-O-methylorobol, piscigenin and 7-O-methylamenthoflavone on cytochrome P450-dependent 7-ethoxycoumarin O-deethylase (ECOD) and glutathione S-transferase (GST) were evaluated in vitro. The 5,4′-dihydroxy-7,5′,3′-trimethoxy-isoflavone was the best inhibitor, inhibiting almost 75% of GST activity. Sequoiaflavone was the most potent inhibitor, inhibiting ECOD assay in 75%. These activities allow us to consider both these flavonoids as potential anticancer and chemopreventive agents