Interethnic variation in the prevalence of claustrophobia during MRI at Singapore General Hospital: does a wider bore MR scanner help?

Background and objectives: It is estimated that 60 million magnetic resonance imaging (MRI) scans are performed annually around the world. Of these, 25% of patients experienced moderate to severe claustrophobia during the procedure. The aim of this study was to determine the prevalence and interethnic variations of patients requiring sedation due to claustrophobia. Another aim was to determine if a wider bore MR scanner was helpful in reducing the incidence of claustrophobia. Methodology: This was an institutional review board-approved study. We retrieved records for 11,813 adult outpatients from the hospital radiological system from 1 January 2012 to 31 December 2012. The data collected included patients’ gender, age, ethnicity, body region scanned, body orientation with respect to the scanner, the types of scanners used, and the need for sedation. Statistical analysis was performed using R 3.0.1. Results: The prevalence of claustrophobic patients requiring sedation was 0.45%, i.e. 53. Of these, 55% were females and 45% males. Among these, 64% were Chinese, 15% Malays, 15% Indians, and 6% were other races. 74% experienced claustrophobia at the 60 cm-wide bore scanners and 26% at 70 cm-wider bore scanners. Referring to Chinese, multivariable regression showed Malays and the Indians were six times and other ethnic groups were 12 times more likely to develop claustrophobia. The incidence of claustrophobia could be reduced by a factor of 2.95 with wider bore scanners. Conclusions: The MR environment is still disturbing to some patients. Feet-in positioning does not significantly minimize claustrophobia. Gender and age had no bearing on claustrophobia. Wider bore MR scanners with a bore size of 70 cm are an obvious choice toward more patient-friendly MR scanners

A study of sutopsy findings in 62 cases of leptospirosis in a metropolitan city in India

Background: Leptospirosis is an important sporadic zoonotic disease caused by the spirochete Leptospira icterohaemorrhagiae . The disease becomes a major public health problem, particularly during the monsoon months. Materials and Methods : Analysis of autopsy findings of 62 cases of clinically suspected leptospirosis was carried out to identify the pathology and determine the cause of death. Results : Most patients were young males who presented with fever, breathlessness, haemoptysis, bleeding, oliguria and icterus. They died after a brief stay in hospital. A post-mortem diagnosis of leptospirosis was made on the basis of characteristic organ findings, aided by results of serology, Levaditi′s staining and / or immunohistochemistry (IHC) on kidney sections. Massive intra-alveolar haemorrhage (48 cases), acute interstitial nephritis and / or acute tubular necrosis (45 cases) and myocarditis (24 cases) were the main autopsy findings. Haemorrhage in various organs like the heart, gastrointestinal tract, brain, pancreas and adrenals were also seen. Thirty of 54 kidney sections were positive for leptospiral antigens by IHC. There was extensive haemorrhages in the lungs in 48 (77%) cases and that was the cause of death in most of these cases. Conclusion : Bleeding into various tissues and organs is the main finding noted in this study. The post-mortem examination of patients dying of leptospirosis revealed that pulmonary haemorrhage was the cause of death in most individuals

A study of sutopsy findings in 62 cases of leptospirosis in a metropolitan city in India

Background: Leptospirosis is an important sporadic zoonotic disease caused by the spirochete Leptospira icterohaemorrhagiae . The disease becomes a major public health problem, particularly during the monsoon months. Materials and Methods : Analysis of autopsy findings of 62 cases of clinically suspected leptospirosis was carried out to identify the pathology and determine the cause of death. Results : Most patients were young males who presented with fever, breathlessness, haemoptysis, bleeding, oliguria and icterus. They died after a brief stay in hospital. A post-mortem diagnosis of leptospirosis was made on the basis of characteristic organ findings, aided by results of serology, Levaditi\u2032s staining and / or immunohistochemistry (IHC) on kidney sections. Massive intra-alveolar haemorrhage (48 cases), acute interstitial nephritis and / or acute tubular necrosis (45 cases) and myocarditis (24 cases) were the main autopsy findings. Haemorrhage in various organs like the heart, gastrointestinal tract, brain, pancreas and adrenals were also seen. Thirty of 54 kidney sections were positive for leptospiral antigens by IHC. There was extensive haemorrhages in the lungs in 48 (77%) cases and that was the cause of death in most of these cases. Conclusion : Bleeding into various tissues and organs is the main finding noted in this study. The post-mortem examination of patients dying of leptospirosis revealed that pulmonary haemorrhage was the cause of death in most individuals

A study of sutopsy findings in 62 cases of leptospirosis in a metropolitan city in India

Background: Leptospirosis is an important sporadic zoonotic disease caused by the spirochete Leptospira icterohaemorrhagiae . The disease becomes a major public health problem, particularly during the monsoon months. Materials and Methods : Analysis of autopsy findings of 62 cases of clinically suspected leptospirosis was carried out to identify the pathology and determine the cause of death. Results : Most patients were young males who presented with fever, breathlessness, haemoptysis, bleeding, oliguria and icterus. They died after a brief stay in hospital. A post-mortem diagnosis of leptospirosis was made on the basis of characteristic organ findings, aided by results of serology, Levaditi′s staining and / or immunohistochemistry (IHC) on kidney sections. Massive intra-alveolar haemorrhage (48 cases), acute interstitial nephritis and / or acute tubular necrosis (45 cases) and myocarditis (24 cases) were the main autopsy findings. Haemorrhage in various organs like the heart, gastrointestinal tract, brain, pancreas and adrenals were also seen. Thirty of 54 kidney sections were positive for leptospiral antigens by IHC. There was extensive haemorrhages in the lungs in 48 (77%) cases and that was the cause of death in most of these cases. Conclusion : Bleeding into various tissues and organs is the main finding noted in this study. The post-mortem examination of patients dying of leptospirosis revealed that pulmonary haemorrhage was the cause of death in most individuals