Merkel cell polyomavirus infection in a patient with Merkel cell carcinoma: A case report

Introduction: Merkel cell carcinoma (MCC) is a rare and highly aggressive malignancy of the skin which occurs mainly in old people and is very uncommon in young individuals. A new tumor virus belonging to the Polyomaviridae family; Merkel Cell Polyomavirus (MCPyV) has recently been identified in more than 80 of MCCs. Case Presentation: We conducted a retrospective review on the archives of the Department of Pathology; Imam Khomeini Hospital Cancer Institute affiliated to Tehran University of Medical Sciences to confirm the MCC samples and we found medical records and samples of a young case with MCC who developed leg skin and scalp tumor six and seven years after bone marrow transplantation, respectively. We analyzed patient formalin-fixed paraffin-embedded samples for the presence of MCPyV DNA using polymerase chain reaction (PCR) method, and the PCR amplicons were subjected to DNA sequencing. Merkel Cell Polyomavirus DNA was detected in both tumors from patient and sequence analysis of the viral LT3 region showed a close homology to strains circulating worldwide. Conclusions: The findings of this study are consistent with the hypothesis that local, systemic, or tumor-induced immunosuppression may allow the MCPyV to initiate skin aggressive cancer. It is necessary to maintain regular check over patients taking immunosuppressive medications for MCPyV infection. Since there is not any information about detection and molecular biology analysis of MCPyV among Iranian patients with MCC, this study provides more information about MCC and MCPyV in Iran. © 2015, Ahvaz Jundishapur University of Medical Sciences

Performance Analysis of A Spark Ignition Engine Using Compressed Natural Gas (CNG) as Fuel

AbstractCompress natural gas (CNG) is also considered as alternative fuel to produce better emission in a vehicle, but the main disadvantage of CNG in comparison to liquid fuel (gasoline) is the lack of power produced for the same capacity of engine. In this study, the single cylinder spark ignition (SI) engine was selected in order to study the effect CNG into the spark ignition engine. The hydraulic dynamometer was used to study the performance of CNG and liquid fuel. The usage of sensor also applies to the test to extract the data during the ignition stage for liquid fuel and CNG. The heat generated by both types of fuel also had been extracted from the tested engine in order to define which usage of fuel would cause a higher heat transfer to the engine. From this study, the result showed that pressure inside cylinder for CNG is 20% less than gasoline. CNG fuel also produced 23% less heat transfer rate compared to gasoline. The results explained why CNG produced 18.5% lower power compared to liquid fuel (gasoline).So, some improvement needs to be done in order to use CNG as fuel

Organizational Trust, Willingness to Share, Membership Involvement and Knowledge Obtaining (Study on Health Industrial Cluster: PERSI, GP FARMASI, And GAKESLAB Association in East Java)

The purposes of this study are to measure and to analyze the influence of organizational trust on group towards knowledge obtaining, willingness to share on group towards knowledge obtaining, membership involvement on group towards knowledge obtaining; membership involvement on group towards knowledge obtaining through organizational trust; willingness to share on group towards knowledge obtaining through organizational trust; membership involvement on group towards knowledge obtaining through willingness to share in East Java Health Tndustry Cluster. Research objects are hospitals, pharmacy manufactures, and health and laboratory device manufactures, those are members of PERSI/GAKESLAB/GP F ARMASI in East Java. Data are primary data type. Population numbers are 188 hospitals, 127 pharmacy manufactures, and 93 health and laboratory device manufactures. Sampling technique applied is multi stage random sampling. Returned and valid numbers of questioner are 133 respondents, spreading in the whole area of East Java. All are analyzed by using SEM (Structural Equation Modelling). Study findings show that organizational trust on group has showed no significant influence towards knowledge obtaining, either in all groups, or specifically in hospital group and pharmacy manufacture group, willingness to share on group has no significant influence towards knowledge obtaining, membership involvement has no significant influence towards knowledge obtaining,mainly on pharmacy manufacture group. Membership involvement on group has showed significant influence towards knowledge obtaining, if it is through organizational trust, willingness to share on group has significant influence towards knowledge obtaining, if it is through organizational trust, and membership involvement on group has significant influence towards knowledge obtaining, if it is through willingness to share. Those mean that indirect influences of organizational trust, willingness to share, and membership involvement on group will be larger towards knowledge obtaining if it is through mediating variable

Application Concept of Social Capital Theory and Social Exchange Theory on Organizational Trust, Willingness To Share, Membership Involvement, and Knowledge Obtaining Dimensions in Industry Cluster

The originality of this research lies in the application of the grand theories {Social Capital and Social Exchange theories) in revealing types of variables which affects knowledge obtaining in industrial clusters. The practical implication of this research is an attempt to produce a new strategy, the cooperation strategy for knowledge obtaining that can be applied to the company in addition to a conceptual foundation for further research about the collaboration between the companies. Limitations of this study is, this is the study with limited to an assessment and conceptual literature excavation that remains to be proved further by research in the field

Five Dimensional Cosmological Models in General Relativity

A Five dimensional Kaluza-Klein space-time is considered in the presence of a perfect fluid source with variable G and $\Lambda$. An expanding universe is found by using a relation between the metric potential and an equation of state. The gravitational constant is found to decrease with time as $G \sim t^{-(1-\omega)}$ whereas the variation for the cosmological constant follows as $\Lambda \sim t^{-2}$, $\Lambda \sim (\dot R/R)^2$ and $\Lambda \sim \ddot R/R$ where $\omega$ is the equation of state parameter and $R$ is the scale factor.Comment: 13 pages, 4 figures, accepted in Int. J. Theor. Phy

PERBEDAAN PENGARUH SENAM OTAK DAN SENAM IRAMA TERHADAP PERKEMBANGAN MOTORIK PADA ANAK DENGAN METODE NARRATIVE REVIEW

Latar Belakang : Salah satu permasalahan yang sering dialami anak adalah keterlambatan perkembangan motorik yang mengakibatkan anak mengalami keterlambatan dalam menangkap informasi, bermain dengan teman sebayanya, dan dalam melakukan aktivitas. Sehingga dalam menaggulangi hal tersebut dapat dilakukan Senam Otak dan Senam Irama . Senam Otak adalah serangkaian latihan yang berbasis gerakan tubuh sederhana yang melibatkan permainan olah tangan dan kaki yang dapat memberikan stimulasi pada otak sedangkan Senam Irama adalah serangkaian latihan yang dibentuk dengan terencana dengan sistematis yang diiringi dengan musik dengan harapan anak tetap aktif dalam melakukan gerakannya. Tujuan Penelitian : Tujuan dari penelitian ini untuk mengetahui apakah ada perbedaan pengaruh senam otak dan senam irama terhadap perkembangan motorik pada anak. Metode Penelitian : Metode pada penelitian ini adalah penelitian narrative review . Pencarian jurnal dilakukan di portal online seperti Google Scholar dan Scient Direct. Hasil penelusuran jurnal didapatkan hasil 10 jurnal yang terdiri dari 5 jurnal tentang senam otak dan 5 jurnal tentang senam irama . Hasil : Hasil review pada 10 jurnal yang masing-masing terdiri dari 5 jurnal tentang senam otak dan senam irama ini didapatkan hasil bahwa terdapat peningkatan perkembangan motorik pada anak setelah dilakukan latihan. Kesimpulan : Ada perbedaan pengaruh senam otak dan senam irama terhadap perkembangan motorik pada anak. Saran : Bagi peneliti selanjutnya untuk menjadi referensi dalam metode penelitian lain, baik dalam bentuk narrative review atau experimental

Performance Analysis Of A Spark Ignition Engine Using Compressed Natural Gas (CNG) As Fuel

Compress natural gas (CNG) is also considered as alternative fuel to produce better emission in a vehicle, but the main disadvantage of CNG in comparison to liquid fuel (gasoline) is the lack of power produced for the same capacity of engine. In this study, the single cylinder spark ignition (SI) engine was selected in order to study the effect CNG into the spark ignition engine. The hydraulic dynamometer was used to study the performance of CNG and liquid fuel. The usage of sensor also applies to the test to extract the data during the ignition stage for liquid fuel and CNG. The heat generated by both types of fuel also had been extracted from the tested engine in order to define which usage of fuel would cause a higher heat transfer to the engine. From this study, the result showed that pressure inside cylinder for CNG is 20% less than gasoline. CNG fuel also produced 23% less heat transfer rate compared to gasoline. The results explained why CNG produced 18.5% lower power compared to liquid fuel (gasoline).So, some improvement needs to be done in order to use CNG as fuel

Large-scale magnetic fields from inflation due to a CPTCPT-even Chern-Simons-like term with Kalb-Ramond and scalar fields

We investigate the generation of large-scale magnetic fields due to the breaking of the conformal invariance in the electromagnetic field through the $CPT$-even dimension-six Chern-Simons-like effective interaction with a fermion current by taking account of the dynamical Kalb-Ramond and scalar fields in inflationary cosmology. It is explicitly demonstrated that the magnetic fields on 1Mpc scale with the field strength of $\sim 10^{-9}$G at the present time can be induced.Comment: 18 pages, 6 figures, version accepted for publication in Eur. Phys. J.

ADAMTS19-associated heart valve defects: Novel genetic variants consolidating a recognizable cardiac phenotype

Recently, ADAMTS19 was identified as a novel causative gene for autosomal recessive heart valve disease (HVD), affecting mainly the aortic and pulmonary valves. Exome sequencing and data repository (CentoMD) analyses were performed to identify patients with ADAMTS19 variants (two families). A third family was recognized based on cardiac phenotypic similarities and SNP array homozygosity. Three novel loss of function (LoF) variants were identified in six patients from three families. Clinically, all patients presented anomalies of the aortic/pulmonary valves, which included thickening of valve leaflets, stenosis and insufficiency. Three patients had (recurrent) subaortic membrane, suggesting that ADAMTS19 is the first gene identified related to discrete subaortic stenosis. One case presented a bi-commissural pulmonary valve. All patients displayed some degree of atrioventricular valve insufficiency. Other cardiac anomalies included atrial/ventricular septal defects, persistent ductus arteriosus, and mild dilated ascending aorta. Our findings confirm that biallelic LoF variants in ADAMTS19 are causative of a specific and recognizable cardiac phenotype. We recommend considering ADAMTS19 genetic testing in all patients with multiple semilunar valve abnormalities, particularly in the presence of subaortic membrane. ADAMTS19 screening in patients with semilunar valve abnormalities is needed to estimate the frequency of the HVD related phenotype, which might be not so rare

Cosmological consequences of a Chaplygin gas dark energy

A combination of recent observational results has given rise to what is currently known as the dark energy problem. Although several possible candidates have been extensively discussed in the literature to date the nature of this dark energy component is not well understood at present. In this paper we investigate some cosmological implications of another dark energy candidate: an exotic fluid known as the Chaplygin gas, which is characterized by an equation of state $p = -A/\rho$, where $A$ is a positive constant. By assuming a flat scenario driven by non-relativistic matter plus a Chaplygin gas dark energy we study the influence of such a component on the statistical properties of gravitational lenses. A comparison between the predicted age of the universe and the latest age estimates of globular clusters is also included and the results briefly discussed. In general, we find that the behavior of this class of models may be interpreted as an intermediary case between the standard and $\Lambda$CDM scenarios.Comment: 7 pages, 5 figures, to appear in Phys. Rev.