3 research outputs found
Immunocompromised patients with acute respiratory distress syndrome : Secondary analysis of the LUNG SAFE database
- Author
- Abad R.D.
- Abe Toshikazu
- Abroug Fekri
- Adams J.C.
- Adamsson Richard O.
- Adolfsson Anne
- Aguirre Janet S
- Aguirre-Bermeo Hernan
- Aisa T.M.
- Aisiku Imo
- Ajetunmobi Olaitan O.
- Aker Mustafa
- Akyol Onat O.
- Al Dorzi H.M.
- Al Jabbary A.S.
- Albaiceta G.M.
- Albarrak M.M.
- Albiero Daniela
- Alda R.S.
- Alejandro Risso V.
- Alexander P.
- Alfonso Alec A.Tallet
- Algaba Á.
- Aliaga Felipe A.
- Alisasis A.U.
- Allan R.M.
- Allue R.M.
- Almekhlafi G.
- Alonso J.G.
- Altaf Wahid
- Alvarez A.M.
- Alvarez Javier
- Amin P.
- Amir Fahd
- Amor M.
- An Youzhong
- Andersen F.H.
- Andoh Kohkichi
- Andruszkiewicz P.
- Aneman Anders
- Antonelli Massimo
- Antônio Ana Carolina P.
- Aoki Nobumasa
- Appelberg Henrik
- Arabi Y.M.
- Araujo A.M.
- Arizmendi A.
- Arnal Jean-Michel
- Artiga M.J.D.
- Artigas A.
- Ascoli Aline
- Au Siu-Ming
- Avila Luis E.
- Azad Raman
- Azevedo L.C.
- Baboi Loredana
- Badie Julio C.
- Bailey Irene M.
- Bailey M.B.
- Bajwa E.
- Balkhi H.
- Baltus Thomas
- Banner-Goodspeed V.M.
- Barberet Guillaume
- Baron Rebecca M
- Baronia Arvind K.
- Barratt-Due Andreas
- Barros F.M.
- Barros N.C.
- Batra H.
- Battle C.E.
- Bauer P.R.
- Beck Eduardo
- Beck O.
- Bedreag O.H.
- Beegle S.H.
- Beitler J.R.
- Bellani Giacomo
- Beloncle François
- Benslama A.
- Beraldo Daniel O.
- Berghe Caroline
- Berkelmans Frantz.
- Besset Sebastien L.
- Bettini Lisandro R.
- Beuret Pascal
- Bezzi Marco G.
- Bhardwaj Vallish K.
- Bhowmick Kaushik
- Biehler Jerome
- Bigot Charlene
- Bihari Shailesh
- Binti Pengiran Haji Ismail Dayangku Hajah Maizatul Aiman
- Biondi Rodrigo S.
- Biscione Roberto R.
- Bisso Mariano Carboni
- Black Colin S.
- Blakeman T.C.
- Blanco J.
- Bolon S.
- Borello Silvana A.
- Borotto Erika E.
- Botteri Marco
- Bouchoucha Slaheddiine
- Boukhazna Messabi
- Bouw M.J.
- Boyd O.
- Bramall J.
- Braschi Antonio
- Brazzi Luca
- Breen Dorothy M.
- Briquet Anais
- Brito V.A.
- Brizuela Matias
- Broman Lars M.
- Brown S.M.
- Browne T.S.
- Bruhn Alejandro R.
- Brunettini Barbara
- Bruns M.M.
- Buensuseso J.A.
- Bugedo G.
- Buise M.P.
- Bulpa Pierre Alain
- Bumbasierevic V.
- Bumbasirevic Vesna
- Burtenshaw A.J.
- Burtin Philippe
- Buzancais Gautier
- Béduneau Gaetan
- Camsooksai Julie
- Canestrini Sergio
- Cani Alma
- Carbayo-Gorriz C.
- Cardonnet Luis P.
- Careless J.P.
- Carpentier Dorothée
- Carreño Nicolás G.
- Carteaux Guillaume
- Casalena Paolo
- Casement J.
- Castro A.G.
- Castro S.
- Catorze N.T.
- Cazorla-Barranquero F.G.
- Ceniceros-Barros A.
- Cereijo E.
- Cerny V.
- Cerrato Valeria I.
- Cervantes M.R.
- Cesar Palazon Sanchez
- Ceunen Helga
- Ceylan Ilkay
- Chabanne Russell
- Chapman R.
- Chau S.K.
- Chelly Jonathan
- Chen Kai
- Chena Ariel
- Cheng M.P.
- Chiche Jean-Daniel
- Chouchene Imed
- Choudry S.
- Christiansen Aage
- Cimic N.
- Cinnella Gilda
- Cirone Rob
- Citalán Johanna E.
- Claraco-Vega L.M.
- Clarkson Kevin P.
- Claverias Laura
- Cohen J.E.
- Cole J.M.
- Collins Daniel V.
- Collyer T.
- Colombo Ricardo
- Combaux Daniele M.
- Combes Alain
- Conti S.
- Cooper R.
- Coppadoro Andrea
- Corneci D.E.
- Cortegiani Andrea
- Cortez Cesar A.
- Coxo C.M.
- Cracchiolo Andrea N.
- Cranshaw J.H.
- Crapelli Giulia
- Crouch D.R.
- Crova Philippe J.
- Csabi P.
- Curley Gerard
- Curto Elena Gallego
- Daldin Julio
- Dangers Laurence
- Danin Pierre-Eric.
- Daubin Cédric
- Daviaud Fabrice
- Davies Kyle G.
- Dawson H.
- de Cima-Iglesias S.
- de Gordoa L.O.R.
- de Haro C.
- de Pablo R.
- de Prost Nicolas
- Dean M.N.
- Declercq Pierre-Louis M.
- Dector D.
- Dector D.M.
- Deicas A.
- Dellamonica Jean
- Dellera Christian
- Delsing A.
- Demirkiran Oktay
- Demoule Alexandre
- Dempsey Ged
- Dendane T.
- Depuydt Pieter
- Derman Suleyman S.
- Di Tomasso Nora N.
- Di Yu D.
- Diaz-Rodriguez Esther
- Dive Alain M.
- Dixit Subhal B.
- do Vale Fernandes A.
- Dolva M.S.
- Donnelly A.
- Dowling A.T.
- Doyen Denis
- Dres Martin
- Dreyer K.R.
- Dunne Eimhin S.
- Dupont Herve
- Duranteau Jacques
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- Ebeid A.
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- Ellis Helen E.
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- Ezzouine Hanane
- Fan E.
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- Farías Pamela A.
- Fawkes Danielle A.
- Ferguson Andrew
- Ferguson Niall D.
- Fernandez Adriana M.
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- Fierro J.M.
- Floris Leda
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- Fontenele Danielle C.
- Formenti Paolo
- Forteza Catalina
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- Franco N.
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- Fusari Maurizio
- Futami Satoru
- Gally Josette
- Ganesan Deeban
- Gao Yuan N.
- Gao Yuan N.
- Garcia Patricio H.
- Gazenkampf A.A.
- Gelée Bruno
- George F.G.
- Ghazi Mohammed
- Gianinetto Hernan
- Giarratano Antonino
- Gillis S.
- Girgin Nermin Kelebek
- Gjedsted Jakob
- Glietsch Rita
- Goldgran-Toledano Dany
- Goligher Ewan C.
- Gomaa D.
- Gomes R.M.
- Gomez Pablo E.
- Gomez-Flores S.S.
- Gonzalez D.R.
- Gonzalez M.
- González R.M.
- González-Salamanca Ángela
- Gonçalves Claudio H.
- Goodson Jennifer C
- Gordo F.
- Gosselin R.J.
- Goubaux Bernard
- Grasselli Giacomo
- Graziani Romano
- Gregoretti Cesare
- Grelon Fabien
- Griffin Ruth
- Grigoriev E.
- Grijalba C.Q.
- Grissom C.K.
- Gritsan A.I.
- Grubissich Nicolas
- Gueret R.M.
- Gurjar Mohan
- Guttormsen A.B.
- Guérin Claude
- Gómez P.R.A.
- Hacking D.J.
- Haddad Youssef
- Hadfield Dan
- Hagan S.J.
- Han Hui
- Han Yi
- Hang Ai Y.
- Hanlon Gabrielle C.
- Harasawa Tomofumi
- Harrois Anatole
- Hashemian Seyed Mohammadreza
- Hashida Tomoaki
- He Z.
- Hedlund Lars
- Heidari Farshad
- Heines S.J.
- Helleberg Johan
- Henderson Galen
- Herbrecht Jean-Etienne.
- Hermosa C.
- Hessell R.J.
- Heunks L.M.
- Higashijima Ushio
- Hirata Akira
- Holzgraefe Bernhard
- Honda Hiroyuki
- Honrubia T.
- Hopf Hans-Bernd F.
- Hopkins Phil
- Hormis Anil P.
- Hou Peter C.
- Hou Sen-Kuang
- Hraiech Sami
- Hua Ma X.
- Huang Qing Q.
- Huang Xiao B.
- Huerta Francisco P.
- Huff N.G.
- Humphreys Sally K.
- Hunt A.
- Hurtado J.
- Hutchison R.A.
- Hutton Paula J.
- Ibañez-Santacruz M.
- Ichikado Kazuya
- Ilutovich Santiago
- Imai Hiroshi
- Imma Vallverdu P.
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- Ioannou N.
- Iotti Giorgio A.
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- Ismail D.
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- Ito Fumihito
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- Jarquin-Badiola Y.D.
- Jassal Mandeep
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- Jiang Liangyan
- Jibaja M.
- Jimenez Antonio G.
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- Jog Sameer A.
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- Judy C.
- Jurado M.T.
- Kadaba Varsha
- Kajtor I.
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- Kamel G.
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- Kamoun Salma
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- Kashiwa Yozo
- Kedelv Hans
- Kennedy Barry
- Khebbeb Samy
- Kheir F.
- Kheir F.M.
- Kimura Hiroyasu
- Kiourtzieva Ellada V.
- Kitch B.T.
- Knapman Karl M.
- Knoll Jenny
- Knowles Serena
- Kol Mark R.
- Kong Jing
- Koyama Kansuke
- Krabler Jens
- Krstevski Amanda
- Kulkarni S.
- Kumar Alek
- Kurahashi K.
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- Laake Jon Henrik
- Labarca Eduardo F.
- Laffey John G.
- Lamb K.D.
- Lanspa M.J.
- Larsson A.
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- Lebbinck Herve
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- Leemann-Refondini Corinne
- Lemiale Virginie
- Lemus J.S.
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- Li Bin
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- Lovazzano Pablo
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- Seven Aylin
- Shah Bhagyesh
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- Sula Hektor
- Sun Renhua
- Surbatovic Maja
- Suzuki Hiroyuki
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- Tulaimat A.
- Twohey Linda
- Uchiyama Akinori
- Ueda Takeshi
- Ueno Keiko
- Umbrello Michele
- Universitat Autònoma de Barcelona
- Unnikrishnan Rammesh
- Uppalapati A.
- Van Haren Frank
- Van Wezel H.M.
- Vargas Monica P.
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- Willett E.L.
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- Wittebole Xavier
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- Wrathall D.W.
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- Wu Ya Q.
- Xin-Hua Qiang
- Xu Yinghao
- Yamaguchi Osamu
- Yamaji Yoshihiro
- Yao Qingchun
- Ye Zheng L.
- Yeatts D.J.
- Yu Rongguo
- Yu Tao
- Yu Wenkui
- Yumha Jacob S.
- Yuste L.J.
- Zacharas Giannis A.
- Zacharowski Kai D.
- Zani Gianluca
- Zantua K.S.
- Zazu Alan
- Zeggwagh Amine Ali
- Zein Salem Ould
- Zender Hervé O.
- Zhai Zhe
- Zhang Fan
- Zhang Xing Y.
- Zhao H.
- Zhao Jun
- Zhao Xian Y.
- Zheng Ruiqiang
- Zhou Fa C.
- Zhou Suming
- Zhu Bao H.
- Zhu Wei H.
- Zogheib Elie
- Zumaran Aguilar Ronald
- Ñamendys-Silva S.A.
- ünal Necmettin
- Publication venue
- Publication date
- 01/01/2018
- Field of study
The aim of this study was to describe data on epidemiology, ventilatory management, and outcome of acute respiratory distress syndrome (ARDS) in immunocompromised patients. Methods: We performed a post hoc analysis on the cohort of immunocompromised patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) study. The LUNG SAFE study was an international, prospective study including hypoxemic patients in 459 ICUs from 50 countries across 5 continents. Results: Of 2813 patients with ARDS, 584 (20.8%) were immunocompromised, 38.9% of whom had an unspecified cause. Pneumonia, nonpulmonary sepsis, and noncardiogenic shock were their most common risk factors for ARDS. Hospital mortality was higher in immunocompromised than in immunocompetent patients (52.4% vs 36.2%; p < 0.0001), despite similar severity of ARDS. Decisions regarding limiting life-sustaining measures were significantly more frequent in immunocompromised patients (27.1% vs 18.6%; p < 0.0001). Use of noninvasive ventilation (NIV) as first-line treatment was higher in immunocompromised patients (20.9% vs 15.9%; p = 0.0048), and immunodeficiency remained independently associated with the use of NIV after adjustment for confounders. Forty-eight percent of the patients treated with NIV were intubated, and their mortality was not different from that of the patients invasively ventilated ab initio. Conclusions: Immunosuppression is frequent in patients with ARDS, and infections are the main risk factors for ARDS in these immunocompromised patients. Their management differs from that of immunocompetent patients, particularly the greater use of NIV as first-line ventilation strategy. Compared with immunocompetent subjects, they have higher mortality regardless of ARDS severity as well as a higher frequency of limitation of life-sustaining measures. Nonetheless, nearly half of these patients survive to hospital discharge. Trial registration: ClinicalTrials.gov, NCT02010073. Registered on 12 December 2013
Immunocompromised patients with acute respiratory distress syndrome: Secondary analysis of the LUNG SAFE database
- Author
- Abad Ricardo Diaz
- Abe Toshikazu
- Abroug Fekri
- Adams John C.
- Adamsson Richard
- Adolfsson Anne
- Aguilar Ronald Zumaran
- Aguirre Janet S.
- Aguirre-Bermeo Hernan
- Aisa Tharwat
- Aisiku Imo
- Ajetunmobi Olaitan
- Aker Mustafa
- Akyol Onat
- Al Dorzi Hasan M.
- Al Jabbary Ahmed
- Albaiceta Guillermo
- Albarrak Mohamad M.
- Albiero Daniela
- Alda Rosa S.
- Alejandro Risso V.
- Alexander Peter
- Alfonso Alec A. Tallet
- Algaba Ángela
- Aliaga Felipe A.
- Alisasis Alain
- Allan Russell
- Allue Raquel Montoiro
- Almekhlafi Ghaleb
- Alonso Javier
- Altaf Wahid
- Alvarez António
- Alvarez Javier
- Amin Pravin
- Amir Fahd
- Amor Mourad
- An Youzhong
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- Virgilio Corcoles G.
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- Wang Shou H.
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- Whitehead Christina
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- Wrathall David
- Wrigge Hermann
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- Xin-Hua Qiang
- Xu Yonghao
- Yamaguchi Osamu
- Yamaji Yoshihiro
- Yao Qingchun
- Ye Zheng L.
- Yeatts Dale
- Yu Rongguo
- Yu Tao
- Yu Wenkui
- Yumha Jacob S.
- Yuste Luis J.
- Zacharas Giannis
- Zacharowski Kai
- Zani Gianluca
- Zantua Kim
- Zazu Alan
- Zeggwagh Amine Ali
- Zein Salem Ould
- Zender Hervé
- Zhai Zhe
- Zhang Fan
- Zhang Xing Y.
- Zhao Huiying
- Zhao Jun
- Zhao Xian Y.
- Zheng Ruiqiang
- Zhou Fa C.
- Zhou Suming
- Zhu Bao
- Zhu Wei H.
- Zogheib Elie
- Ñamendys-Silva Silvio A.
- ünal Necmettin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
Background: The aim of this study was to describe data on epidemiology, ventilatory management, and outcome of acute respiratory distress syndrome (ARDS) in immunocompromised patients. Methods: We performed a post hoc analysis on the cohort of immunocompromised patients enrolled in the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE) study. The LUNG SAFE study was an international, prospective study including hypoxemic patients in 459 ICUs from 50 countries across 5 continents. Results: Of 2813 patients with ARDS, 584 (20.8%) were immunocompromised, 38.9% of whom had an unspecified cause. Pneumonia, nonpulmonary sepsis, and noncardiogenic shock were their most common risk factors for ARDS. Hospital mortality was higher in immunocompromised than in immunocompetent patients (52.4% vs 36.2%; p < 0.0001), despite similar severity of ARDS. Decisions regarding limiting life-sustaining measures were significantly more frequent in immunocompromised patients (27.1% vs 18.6%; p < 0.0001). Use of noninvasive ventilation (NIV) as first-line treatment was higher in immunocompromised patients (20.9% vs 15.9%; p = 0.0048), and immunodeficiency remained independently associated with the use of NIV after adjustment for confounders. Forty-eight percent of the patients treated with NIV were intubated, and their mortality was not different from that of the patients invasively ventilated ab initio. Conclusions: Immunosuppression is frequent in patients with ARDS, and infections are the main risk factors for ARDS in these immunocompromised patients. Their management differs from that of immunocompetent patients, particularly the greater use of NIV as first-line ventilation strategy. Compared with immunocompetent subjects, they have higher mortality regardless of ARDS severity as well as a higher frequency of limitation of life-sustaining measures. Nonetheless, nearly half of these patients survive to hospital discharge. Trial registration: ClinicalTrials.gov, NCT02010073. Registered on 12 December 2013
IV. Securing Domestic Support for Ratification – Negotiations at Level II
- Author
- Abad R. D.
- Abe T.
- Abroug F.
- Adams J. C.
- Adamsson R. O.
- Adolfsson A.
- Aguilar R. Z.
- Aguirre J. S.
- Aguirre-Bermeo H.
- Aisa T. M.
- Aisiku I.
- Ajetunmobi O. O.
- Aker M.
- Akyol O. O.
- Al Dorzi H. M.
- Al Jabbary A. S.
- Albaiceta G. M.
- Albarrak M. M.
- Albiero D.
- Alda R. S.
- Alejandro R. V.
- Alexander P.
- Alfonso A. A. T.
- Algaba A.
- Aliaga F. A.
- Alisasis A. U.
- Allan R. M.
- Allue R. M.
- Almekhlafi G.
- Alonso J. G.
- Altaf W.
- Alvarez A. M.
- Alvarez J.
- Amin P.
- Amir F.
- Amor M.
- An Y.
- Andersen F. H.
- Andoh K.
- Andruszkiewicz P.
- Aneman A.
- Antonelli M.
- Antonelli M. M.
- Antonio A. C. P.
- Aoki N.
- Appelberg H.
- Arabi Y.
- Arabi Y. M.
- Araujo A. M.
- Arizmendi A.
- Arnal J. -M.
- Artiga M. J. D.
- Artigas A.
- Ascoli A.
- Au S. -M.
- Avila L. E.
- Azad R.
- Azevedo L. C.
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- Badie J. C.
- Bailey I. M.
- Bailey M. B.
- Bajwa E.
- Balkhi H.
- Baltus T.
- Banner-Goodspeed V. M.
- Barberet G.
- Baron R. M.
- Baronia A. K.
- Barratt-Due A.
- Barros F. M.
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- Battle C. E.
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- Bellani G.
- Beloncle F.
- Benslama A.
- Beraldo D. O.
- Berghe C.
- Berkelmans F.
- Besset S. L.
- Bettini L. R.
- Beuret P.
- Bezzi M. G.
- Bhardwaj V. K.
- Bhowmick K.
- Biehler J.
- Bigot C.
- Bihari S.
- Binti Pengiran Haji Ismail D. H. M. A.
- Biondi R. S.
- Biscione R. R.
- Bisso M. C.
- Black C. S.
- Blakeman T. C.
- Blanco J.
- Bolon S.
- Borello S. A.
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- Publication venue
- Graduate Institute Publications
- Publication date
- 30/06/2014
- Field of study
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