12,285 research outputs found
A 3D Printed Toolbox for Opto-Mechanical Components
Nowadays is very common to find headlines in the media where it is stated
that 3D printing is a technology called to change our lives in the near future.
For many authors, we are living in times of a third industrial revolution.
Howerver, we are currently in a stage of development where the use of 3D
printing is advantageous over other manufacturing technologies only in rare
scenarios. Fortunately, scientific research is one of them. Here we present the
development of a set of opto-mechanical components that can be built easily
using a 3D printer based on Fused Filament Fabrication (FFF) and parts that can
be found on any hardware store. The components of the set presented here are
highly customizable, low-cost, require a short time to be fabricated and offer
a performance that compares favorably with respect to low-end commercial
alternatives.Comment: 9 pages, 9 figure
Comment on ``Scaling Laws for a System with Long-Range Interactions within Tsallis Statistics''
In their recent Letter [Phys. Rev. Lett. 83, 4233 (1999)], Salazar and Toral
(ST) study numerically a finite Ising chain with non-integrable interactions
decaying like 1/r^(d+sigma) where -d <= sigma <= 0 (like ST, we discuss general
dimensionality d). In particular, they explore a presumed connection between
non-integrable interactions and Tsallis's non-extensive statistics. We point
out that (i) non-integrable interactions provide no more motivation for Tsallis
statistics than do integrable interactions, i.e., Gibbs statistics remain
meaningful for the non-integrable case, and in fact provide a {\em complete and
exact treatment}; and (ii) there are undesirable features of the method ST use
to regulate the non-integrable interactions.Comment: Accepted for publication in Phys. Rev. Let
Regulation of Synaptic Pumilio Function by an Aggregation-Prone Domain
We identified Pumilio (Pum), a Drosophila translational repressor, in a computational search for metazoan proteins whose activities might be regulated by assembly into ordered aggregates. The search algorithm was based on evolutionary sequence conservation patterns observed for yeast prion proteins, which contain aggregation-prone glutamine/asparagine (Q/N)-rich domains attached to functional domains of normal amino acid composition. We examined aggregation of Pum and its nematode ortholog PUF-9 by expression in yeast. A domain of Pum containing the Q/N-rich sequence, denoted as NQ1, the entire Pum N terminus, and the complete PUF-9 protein localize to macroscopic aggregates (foci) in yeast. NQ1 and PUF-9 can generate the yeast Pin+ trait, which is transmitted by a heritable aggregate. NQ1 also assembles into amyloid fibrils in vitro. In Drosophila, Pum regulates postsynaptic translation at neuromuscular junctions (NMJs). To assess whether NQ1 affects synaptic Pum activity in vivo, we expressed it in muscles. We found that it negatively regulates endogenous Pum, producing gene dosage-dependent pum loss-of-function NMJ phenotypes. NQ1 coexpression also suppresses lethality and NMJ phenotypes caused by overexpression of Pum in muscles. The Q/N block of NQ1 is required for these phenotypic effects. Negative regulation of Pum by NQ1 might be explained by formation of inactive aggregates, but we have been unable to demonstrate that NQ1 aggregates in Drosophila. NQ1 could also regulate Pum by a "dominant-negative" effect, in which it would block Q/N-mediated interactions of Pum with itself or with cofactors required for translational repression
Sources of information as determinants of product and process innovation
In this paper we use a panel of manufacturing firms in Spain to examine the extent to which they use internal and external sources of information (customers, suppliers, competitors, consultants and universities) to generate product and process innovation. Our results show that, although internal sources are influential, external sources of information are key to achieve innovation performance. These results are in line with the open innovation literature because they show that firms that are opening up their innovation process and that use different information sources have a greater capacity to generate innovations. We also find that the importance of external sources of information varies depending on the type of innovation (product or process) considered. To generate process innovation, firms mainly rely on suppliers while, to generate product innovation, the main contribution is from customers. The potential simultaneity between product and process innovation is also taken into consideration. We find that the generation of both types of innovation is not independent. © 2016 Gómez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Phase transition in a super superspin glass
We here confirm the occurrence of spin glass phase transition and extract
estimates of associated critical exponents of a highly monodisperse and densely
compacted system of bare maghemite nanoparticles. This system has earlier been
found to behave like an archetypal spin glass, with e.g. a sharp transition
from paramagnetic to non-equilibrium behavior, suggesting that this system
undergoes a spin-glass phase transition at a relatively high temperature,
140 K.Comment: 4 pages, 3 figure
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