Barriers, Attitudes, And Self-Efficacy Of People With Disabilities In Recreational Sports Activities Participation In Saudi Arabia

This study investigates factors that predict participation of people with disabilities in recreational sports. Kajian ini menyiasat faktor-faktor yang meramalkan penyertaan orang kurang upaya dalam sukan rekreas

Physical Activity and Sedentary Behaviors in Primary School Children in Saudi Arabia during the COVID-19 Pandemic: Association with Parents' Behaviors.

During the COVID-19 pandemic, a few studies used accelerometers to assess physical activity (PA) and sedentary behavior in the family context. This study aimed to assess children and parents' moderate and vigorous physical activity (MVPA) and sedentary time, as well as their relationship in MVPA and sedentary time. Data were collected from 30 parent-child dyads during the COVID-pandemic for seven days, using a hip-worn accelerometer. Children and parents engaged in 65.6 and 34.6 min/day in MVPA and 442.2 and 427.9 min/day sedentary, respectively. There was no evidence of gender difference in MVPA and sedentary between boys and girls. Male parent spent more time in MVPA than female parents. A total of 50% of children and 53.3% of parents met the recommended PA. Children's MVPA and sedentary time were both correlated with that of their parents. Adjusted linear regression showed that only child MVPA was negatively associated with their parents' MVPA. There is evidence that multi-level interventions involving parents and children are more effective than interventions focusing on a single group. This study also provides evidence to support the link between MVPA and sedentary time between parents and children. Generalization of the findings is difficult due to the bias of self-selection sample

Enhancing hair regeneration: Recent progress in tailoring nano-structured lipid carriers through surface modification strategies

Background and purpose: Hair loss is a prevalent problem affecting millions of people worldwide, necessitating innovative and efficient regrowth approaches. Nanostructured lipid carriers (NLCs) have become a hopeful option for transporting bioactive substances to hair follicles because of their compatibility with the body and capability to improve drug absorption. Review approach: Recently, surface modification techniques have been used to enhance hair regeneration by improving the customization of NLCs. These techniques involve applying polymers, incorporating targeting molecules, and modifying the surface charge. Key results: The conversation focuses on how these techniques enhance stability, compatibility with the body, and precise delivery to hair follicles within NLCs. Moreover, it explains how surface-modified NLCs can improve the bioavailability of hair growth-promoting agents like minoxidil and finasteride. Furthermore, information on how surface-modified NLCs interact with hair follicles is given, uncovering their possible uses in treating hair loss conditions. Conclusion: This review discusses the potential of altering the surface of NLCs to customize them for enhanced hair growth. It offers important information for upcoming studies on hair growth

Pharmaceutical Coating and Its Different Approaches, a Review

Coating the solid dosage form, such as tablets, is considered common, but it is a critical process that provides different characteristics to tablets. It increases the value of solid dosage form, administered orally, and thus meets diverse clinical requirements. As tablet coating is a process driven by technology, it relies on advancements in coating techniques, equipment used for the coating process, evaluation of coated tablets, and coated material used. Although different techniques were employed for coating purposes, which may be based on the use of solvents or solvent-free, each of the methods used has its advantages and disadvantages, and the techniques need continued modification too. During the process of film coating, several inter-and intra-batch uniformity of coated material on the tablets is considered a critical point that ensures the worth of the final product, particularly for those drugs that contain an active medicament in the coating layer. Meanwhile, computational modeling and experimental evaluation were actively used to predict the impact of the operational parameters on the final product quality and optimize the variables in tablet coating. The efforts produced by computational modeling or experimental evaluation not only save cost in optimizing the coating process but also saves time. This review delivers a brief review on film coating in solid dosage form, which includes tablets, with a focus on the polymers and processes used in the coating. At the end, some pharmaceutical applications were also discussed

An Insight into Preparatory Methods and Characterization of Orodispersible Film—A Review

Over the past few decades, researchers and companies have been trying to develop novel drug delivery systems to ensure safety, efficacy, compliance, and patient acceptability. Nowadays drug discovery and development are expensive, complex, and time-consuming processes, but trends are moving toward novel drug delivery systems. This delivery system helps to achieve drug response by local and systemic action through different routes. This novel approach of preparing orodispersible films (ODFs) provides benefits to paediatric, geriatric, and bedridden patients. This review paper aims to provide details on the preparation, characterization, and evaluation of ODFs; it also aims to focus on the positive and negative factors that affect film formulation and give an insight into potential drug candidates and polymers for use in ODFs. ODFs are effective, safe, and have good bioavailability as compared to fast-disintegrating tablets. The novel approach has various advantages because it provides instant effects in emergency situations and in schizophrenic and dysphasic patients without the need for taking water, the films disintegrating within a few seconds in the oral cavity. The solvent casting method is the most frequently used technique to develop ODFs, using film-forming polymers, which have a fast disintegration time, improved drug dissolution, and better drug contents

Osteoarthritis of the Knee: Review of Risk Factors and Treatment Programs with Special Reference to Evidence-Based Research

Osteoarthritis is a widespread disease leading to physical disability affecting quality of life. It is primarily regarded as a cartilage disease but affect all tissues of a joint. Osteoarthritis can be regarded as an organ failure. Knee osteoarthritis is common in Kuwait, especially in women. The main symptoms are pain, stiffness and weakness affecting knee function. The diagnosis is made by history and clinical examination. A weight-bearing radiograph will fully establish the diagnosis. Many of the patients are also obese, diabetic, hypertensive or affected by other organ failures. The aim is to reduce knee pain and improve knee function which is also beneficial for the other diseases. Initially, we recommend self-management by information about knee osteoarthritis, daily exercise of any type which is pleasant for the individual like 'walking 10-30 minutes once or twice daily in order to induce light to moderate cartilage load. Further, regular muscle training to increase especially pelvis and lower leg strength and realistic programs to reduce weight is advised. Regular support by a primary care doctor, a physiotherapist or a coach is beneficial. The program is demanding, as it means a change of life-style. Different modalities of non-operative treatment are physiotherapy, pharmacological treatment by analgesics / NSAIDs / glucosamine and injection of steroids or hyaluronic acid. The effect of the pharmacological treatment programs vary. Often the outcome, by evidence based research, is low or at best moderate. If self-management and non-operative treatment fails and the symptoms are pronounced, surgery is an option. Knee prosthesis is the main alternative

Knee Arthroplasty in Kuwait during 25 Years: A National Presentation and an International Review

Since 1984, 577 knee arthroplasty operations were performed in Al Razi Orthopedic hospital in Kuwait. An increase in the number of these operations occurred during the last four years and in 2007 there were almost 100 knee arthroplasty operations performed. Six out of seven operated patients were female. The mean age at operation was 67 years for male and 62 years for female patients. The vast majority were of the total knee arthroplasty type. In Sweden, with a total population of almost 10 million people, 10,544 primary knee prosthesis were implanted during 2006. In Kuwait, there is no certain statistics regarding the actual number of knee arthroplasty operations as Kuwaiti patients are also operated in private hospitals within and outside the country. It is estimated that 200 - 300 knee arthroplasty operations are performed annually on Kuwaitis. In order to get better epidemiological data and in order to improve the quality assurance of Knee and Hip arthroplasty operations in Kuwait, we propose that a national register is organised. National registers are in use in many other countries. The main indication for a knee arthroplasty is to relieve knee pain and to improve knee function. The operation allows for an active life-style. An active lifestyle, with more walking, is an advantage not only for the knee, but also for the general health. It also helps to better control other diseases like diabetes and obesity. The use of knee arthroplasties in Kuwait is increasing and the outcome of the procedure is generally favorable. It is not an overstatement to say that a well functioning knee arthroplasty means an increased quality of the whole life

Technologies for Solubility, Dissolution and Permeation Enhancement of Natural Compounds

The current review is based on the advancements in the field of natural therapeutic agents which could be utilized for a variety of biomedical applications and against various diseases and ailments. In addition, several obstacles have to be circumvented to achieve the desired therapeutic effectiveness, among which limited dissolution and/or solubility and permeability are included. To counteract these issues, several advancements in the field of natural therapeutic substances needed to be addressed. Therefore, in this review, the possible techniques for the dissolution/solubility and permeability improvements have been addressed which could enhance the dissolution and permeability up to several times. In addition, the conventional and modern isolation and purification techniques have been emphasized to achieve the isolation and purification of single or multiple therapeutic constituents with convenience and smarter approaches. Moreover, a brief overview of advanced natural compounds with multiple therapeutic effectiveness have also been anticipated. In brief, enough advancements have been carried out to achieve safe, effective and economic use of natural medicinal agents with improved stability, handling and storage

Orally Administered, Biodegradable and Biocompatible Hydroxypropyl–β–Cyclodextrin Grafted Poly(methacrylic acid) Hydrogel for pH Sensitive Sustained Anticancer Drug Delivery

In the current study, a pH sensitive intelligent hydroxypropyl–β–cyclodextrin-based polymeric network (HP-β-CD-g-MAA) was developed through a solution polymerization technique for site specific delivery of cytarabine in the colonic region. Prepared hydrogel formulations were characterized through cytarabine loading (%), ingredient’s compatibility, structural evaluation, thermal integrity, swelling pattern, release behavior and toxicological profiling in rabbits. Moreover, the pharmacokinetic profile of cytarabine was also determined in rabbits. New polymer formation was evident from FTIR findings. The percentage loaded into the hydrogels was in the range of 37.17–79.3%. Optimum swelling ratio of 44.56 was obtained at pH 7.4. Cytarabine release was persistent and in a controlled manner up to 24 h. In vitro degradation of hydrogels was more pronounced at intestinal pH as compared to acidic pH. Toxicity studies proved absence of any ocular, skin and oral toxicity, thus proving biocompatibility of the fabricated network. Hydrogels exhibited longer plasma half-life (8.75 h) and AUC (45.35 μg.h/mL) with respect to oral cytarabine solution. Thus, the developed hydrogel networks proved to be excellent and biocompatible cargo for prolonged and site-specific delivery of cytarabine in the management of colon cancer