Optimal placement of excitations and sensors by simulated annealing

The optimal placement of discrete actuators and sensors is posed as a combinatorial optimization problem. Two examples for truss structures were used for illustration; the first dealt with the optimal placement of passive dampers along existing truss members, and the second dealt with the optimal placement of a combination of a set of actuators and a set of sensors. Except for the simplest problems, an exact solution by enumeration involves a very large number of function evaluations, and is therefore computationally intractable. By contrast, the simulated annealing heuristic involves far fewer evaluations and is best suited for the class of problems considered. As an optimization tool, the effectiveness of the algorithm is enhanced by introducing a number of rules that incorporate knowledge about the physical behavior of the problem. Some of the suggested rules are necessarily problem dependent

Influence of analysis and design models on minimum weight design

The results of numerical experiments designed to illustrate how the minimum weight design, accuracy, and cost can be influenced by: (1) refinement of the finite element analysis model and associated load path problems, and (2) refinement of the design variable linking model are examined. The numerical experiments range from simple structures where the modelling decisions are relatively obvious and less costly to the more complex structures where such decisions are less obvious and more costly. All numerical experiments used employ the dual formulation in ACCESS-3 computer program. Guidelines are suggested for creating analysis and design models that predict a minimum weight structure with greater accuracy and less cost. These guidelines can be useful in an interactive optimization environment and in the design of heuristic rules for the development of knowledge-based expert optimization systems

A call for the aggressive treatment of oligometastatic and oligo-recurrent non-small cell lung cancer.

Metastatic non-small cell lung cancer (NSCLC) carries a dismal prognosis. Clinical evidence suggests the existence of an intermediate, or oligometastatic, state when metastases are limited in number and/or location. In addition, following initial curative therapy, many patients present with limited metastatic disease, or oligo-recurrence. Metastasis-directed, anti-cancer therapies may benefit these patients. A growing evidence-base supports the use of hypofractionated, image-guided radiotherapy (HIGRT) for a variety of malignant conditions including inoperable stage I NSCLC and many metastatic sites. When surgical resection is not possible, HIGRT offers an effective alternative for local treatment of limited metastatic disease. Early studies have produced promising results when HIGRT was delivered to all known sites of disease in patients with oligometastatic/oligo-recurrent NSCLC. In a population of patients formerly considered rapidly terminal, these studies report five year overall survival rates of 13-22%. HIGRT for metastatic NSCLC warrants further study. We call for large, intergroup, and even international randomized trials incorporating HIGRT and other metastasis-directed therapies into the treatment of patients with oligometastatic/oligo-recurrent NSCLC

The Performance of the Robo-AO Laser Guide Star Adaptive Optics System at the Kitt Peak 2.1-m Telescope

Robo-AO is an autonomous laser guide star adaptive optics system recently commissioned at the Kitt Peak 2.1-m telescope. Now operating every clear night, Robo-AO at the 2.1-m telescope is the first dedicated adaptive optics observatory. This paper presents the imaging performance of the adaptive optics system in its first eighteen months of operations. For a median seeing value of $1.31^{\prime\prime}$, the average Strehl ratio is 4\% in the $i^\prime$ band and 29\% in the J band. After post-processing, the contrast ratio under sub-arcsecond seeing for a $2\leq i^{\prime} \leq 16$ primary star is five and seven magnitudes at radial offsets of $0.5^{\prime\prime}$ and $1.0^{\prime\prime}$, respectively. The data processing and archiving pipelines run automatically at the end of each night. The first stage of the processing pipeline shifts and adds the data using techniques alternately optimized for stars with high and low SNRs. The second "high contrast" stage of the pipeline is eponymously well suited to finding faint stellar companions.Comment: 12 pages, 16 figures, to be submitted to PAS

Laboratory Astrophysics Division of the AAS (LAD)

The purpose of the Laboratory Astrophysics Division (LAD) is to advance our understanding of the Universe through the promotion of fundamental theoretical and experimental research into the underlying processes that drive the Cosmos. LAD represents all areas of astrophysics and planetary sciences. The first new AAS Division in more than 30 years, the LAD traces its history back to the recommendation from the scientific community via the White Paper from the 2006 NASA-sponsored Laboratory Astrophysics Workshop. This recommendation was endorsed by the Astronomy and Astrophysics Advisory Committee (AAAC), which advises the National Science Foundation (NSF), the National Aeronautics and Space Administration (NASA), and the U.S. Department of Energy (DOE) on selected issues within the fields of astronomy and astrophysics that are of mutual interest and concern to the agencies. In January 2007, at the 209th AAS meeting, the AAS Council set up a Steering Committee to formulate Bylaws for a Working Group on Laboratory Astrophysics (WGLA). The AAS Council formally established the WGLA with a five-year mandate in May 2007, at the 210th AAS meeting. From 2008 through 2012, the WGLA annually sponsored Meetings in-a-Meeting at the AAS Summer Meetings. In May 2011, at the 218th AAS meeting, the AAS Council voted to convert the WGLA, at the end of its mandate, into a Division of the AAS and requested draft Bylaws from the Steering Committee. In January 2012, at the 219th AAS Meeting, the AAS Council formally approved the Bylaws and the creation of the LAD. The inaugural gathering and the first business meeting of the LAD were held at the 220th AAS meeting in Anchorage in June 2012. You can learn more about LAD by visiting its website at http://lad.aas.org/ and by subscribing to its mailing list

Robo-AO Kepler Survey IV: the effect of nearby stars on 3857 planetary candidate systems

We present the overall statistical results from the Robo-AO Kepler planetary candidate survey, comprising of 3857 high-angular resolution observations of planetary candidate systems with Robo-AO, an automated laser adaptive optics system. These observations reveal previously unknown nearby stars blended with the planetary candidate host star which alter the derived planetary radii or may be the source of an astrophysical false positive transit signal. In the first three papers in the survey, we detected 440 nearby stars around 3313 planetary candidate host stars. In this paper, we present observations of 532 planetary candidate host stars, detecting 94 companions around 88 stars; 84 of these companions have not previously been observed in high-resolution. We also report 50 more-widely-separated companions near 715 targets previously observed by Robo-AO. We derive corrected planetary radius estimates for the 814 planetary candidates in systems with a detected nearby star. If planetary candidates are equally likely to orbit the primary or secondary star, the radius estimates for planetary candidates in systems with likely bound nearby stars increase by a factor of 1.54, on average. We find that 35 previously-believed rocky planet candidates are likely not rocky due to the presence of nearby stars. From the combined data sets from the complete Robo-AO KOI survey, we find that 14.5\pm0.5% of planetary candidate hosts have a nearby star with 4", while 1.2% have two nearby stars and 0.08% have three. We find that 16% of Earth-sized, 13% of Neptune-sized, 14% of Saturn-sized, and 19% of Jupiter-sized planet candidates have detected nearby stars.Comment: Accepted to the Astronomical Journa

Robo-AO Kepler Survey V: The effect of physically associated stellar companions on planetary systems

The Kepler light curves used to detect thousands of planetary candidates are susceptible to dilution due to blending with previously unknown nearby stars. With the automated laser adaptive optics instrument, Robo-AO, we have observed 620 nearby stars around 3857 planetary candidates host stars. Many of the nearby stars, however, are not bound to the KOI. In this paper, we quantify the association probability between each KOI and detected nearby stars through several methods. Galactic stellar models and the observed stellar density are used to estimate the number and properties of unbound stars. We estimate the spectral type and distance to 145 KOIs with nearby stars using multi-band observations from Robo-AO and Keck-AO. We find most nearby stars within 1" of a Kepler planetary candidate are likely bound, in agreement with past studies. We use likely bound stars as well as the precise stellar parameters from the California Kepler Survey to search for correlations between stellar binarity and planetary properties. No significant difference between the binarity fraction of single and multiple planet systems is found, and planet hosting stars follow similar binarity trends as field stars, many of which likely host their own non-aligned planets. We find that hot Jupiters are ~4x more likely than other planets to reside in a binary star system. We correct the radius estimates of the planet candidates in characterized systems and find that for likely bound systems, the estimated planetary candidate radii will increase on average by a factor of 1.77, if either star is equally likely to host the planet. We find that the planetary radius gap is robust to the impact of dilution, and find an intriguing 95%-confidence discrepancy between the radius distribution of small planets in single and binary systems.Comment: 19 pages, 12 figures, submitted to AAS Journal

GC-Biased Evolution Near Human Accelerated Regions

Regions of the genome that have been the target of positive selection specifically along the human lineage are of special importance in human biology. We used high throughput sequencing combined with methods to enrich human genomic samples for particular targets to obtain the sequence of 22 chromosomal samples at high depth in 40 kb neighborhoods of 49 previously identified 100–400 bp elements that show evidence for human accelerated evolution. In addition to selection, the pattern of nucleotide substitutions in several of these elements suggested an historical bias favoring the conversion of weak (A or T) alleles into strong (G or C) alleles. Here we found strong evidence in the derived allele frequency spectra of many of these 40 kb regions for ongoing weak-to-strong fixation bias. Comparison of the nucleotide composition at polymorphic loci to the composition at sites of fixed substitutions additionally reveals the signature of historical weak-to-strong fixation bias in a subset of these regions. Most of the regions with evidence for historical bias do not also have signatures of ongoing bias, suggesting that the evolutionary forces generating weak-to-strong bias are not constant over time. To investigate the role of selection in shaping these regions, we analyzed the spatial pattern of polymorphism in our samples. We found no significant evidence for selective sweeps, possibly because the signal of such sweeps has decayed beyond the power of our tests to detect them. Together, these results do not rule out functional roles for the observed changes in these regions—indeed there is good evidence that the first two are functional elements in humans—but they suggest that a fixation process (such as biased gene conversion) that is biased at the nucleotide level, but is otherwise selectively neutral, could be an important evolutionary force at play in them, both historically and at present

Localization Error Bounds for 5G mmWave Systems under I/Q Imbalance

Location awareness is expected to play a significant role in 5G millimeter-wave (mmWave) communication systems. One of the basic elements of these systems is quadrature amplitude modulation (QAM), which has in-phase and quadrature (I/Q) modulators. It is not uncommon for transceiver hardware to exhibit an imbalance in the I/Q components, causing degradation in data rate and signal quality. Under an amplitude and phase imbalance model at both the transmitter and receiver, 2D positioning performance in 5G mmWave systems is considered. Towards that, we derive the position and orientation error bounds and study the effects of the I/Q imbalance parameters on the derived bounds. The numerical results reveal that I/Q imbalance impacts the performance similarly, whether it occurs at the transmitter or the receiver, and can cause a degradation up to 12% in position and orientation estimation accuracy

Development of Y-Ba-Cu-O Superconductors for Magnetic Bearings

The material requirements, material manufacturing and magnetic properties that are relevant to fabrication of High Temperature Superconductor (HTS) magnetic bearings have been discussed. It is found that the seeded-melt-texturing method can be used to fabricate the single domain material that is required to achieve the best magnetic properties. Trapped-field mapping has been used as a non-destructive tool to determine the single-domain nature of the HTS material and quantity of the HTS disks. Both the trapped field and the levitation force of the Y-Ba-Cu-O disks are found to be strongly sensitive to the oxygen content