Analysis of antiviral therapy resistant mutations of Omani HBV isolates.

<p>The amino acid sequences of the HBV polymerase (reverse transcriptase region; aa rtM1 to rtL275) of the Omani resistant mutation isolates were aligned with the corresponding region of the reference sequences (HBV-genotypes A to H; GenBank accession numbers are denoted) by ClustalW with Neighbor Joining method and 1000 bootstrap replicates. Described antiviral resistant mutations were highlighted and denoted at the top (e.g., L80V).</p

Analysis of antiviral therapy resistant mutations of Omani HBV isolates.

<p>The amino acid sequences of the HBV polymerase (reverse transcriptase region; aa rtM1 to rtL275) of the Omani resistant mutation isolates were aligned with the corresponding region of the reference sequences (HBV-genotypes A to H; GenBank accession numbers are denoted) by ClustalW with Neighbor Joining method and 1000 bootstrap replicates. Described antiviral resistant mutations were highlighted and denoted at the top (e.g., L80V).</p

Clinical profiles of HBsAg-positive patients of Oman.

<p>Clinical profiles of HBsAg-positive patients of Oman.</p

Distribution of antiviral resistance mutations.

<p>*denotes p<0.05; ^aValues are given as log₁₀ international units (IU)/ml; ND: Not done; F = female, M = male.</p

Epidemiology of Varicella Zoster Virus and Herpes Zoster Virus in Gulf Cooperation Council Countries: A Review of the Literature

  Article full text  The article associated with this page has been accepted for online publication and is in the final stages of production. The link to the full text will be made available on this page in the next few days.  The above graphical abstract represents the opinions of the authors. For a full list of declarations, including funding and author disclosure statements, and copyright information, please see the full text online. (see “read the peer-reviewed publication” opposite). </p

Analysis of escape mutants of Omani HBV isolates.

<p>The amino acid sequences in the “a” determinant region of the Omani escape mutant isolates were aligned with the corresponding region of the reference sequences (HBV-genotypes A to H; GenBank accession numbers are denoted) by ClustalW with Neighbor Joining method and 1000 bootstrap replicates. Amino acid substitutions were highlighted.</p

Distribution of S-gene variants of Omani HBV isolates.

a<p>Values are given as log₁₀ international units (IU)/ml; ND: Not done; F = female, M = male.</p

HBV-specific primers for detection, genotyping, and mutational analysis.

<p>Nucleotide position is according to the HBV reference strain GenBank accession number HM011485.</p

Phylogenetic analysis of Omani HBV strains.

<p>Phylogenetic analysis inferred from distance analysis (Kimura 2 parameters model) and neighbor-joining reconstruction from a partially overlapping region of P and S genes (from nt479 to nt766) of 170 Omani HBV DNA-positive isolates. The reference strains were denoted by HBV genotype and “•” signal with the GenBank accession number, respectively (for example: “A-HM011485•”). The Omani samples were numbered, and especially the double-infected samples were highlighted by the “▪” signal. (The numbers at the nodes indicate bootstrapping values.).</p

Mutations in the “a” determinant domain of Omani HBV isolates.

<p>Mutations in the “a” determinant domain of Omani HBV isolates.</p