IN-VITRO THROMBOLYTIC ACTIVITY OF HERBAL ANTI-ARTHEROSCLEROSIS FORMULATION

In recent study, the Herbal Anti-atherosclerosis Formulation comprising of Lemon, Garlic, Ginger and Apple fruit extract vinegar have been generally recognized as agents for prevention and treatment of cardiovascular and other metabolic ailments, atherosclerosis, hyperlipidemia, thrombosis, hypertension and diabetes and cholesterol bringing down impact. Accordingly, the present study was intended to investigate thrombolytic properties of Herbal Anti-atherosclerosis Formulation. Natural Antiatherosclerosis Formulation of demonstrated exceptionally huge (P <0.001) clot lytic properties in different blood samples. The percent clot lytic activity was compared with negative control (water) and standard enzyme positive control (streptokinase). The mean % of clot lysis for water and streptokinase was discovered 4.71% and 86.21% individually. Then again the mean percent clot lytic activity of Herbal Anti-atherosclerosis Formulation was discovered 29.51%, which is huge contrast and the positive and negative control. The present research recommends that Herbal Anti-atherosclerosis Formulation has significant thrombolytic action. Consequently the detailing may be a wellspring of powerful natural medication

IN-VITRO THROMBOLYTIC ACTIVITY OF HERBAL ANTI-ARTHEROSCLEROSIS FORMULATION

In recent study, the Herbal Anti-atherosclerosis Formulation comprising of Lemon, Garlic, Ginger and Apple fruit extract vinegar have been generally recognized as agents for prevention and treatment of cardiovascular and other metabolic ailments, atherosclerosis, hyperlipidemia, thrombosis, hypertension and diabetes and cholesterol bringing down impact. Accordingly, the present study was intended to investigate thrombolytic properties of Herbal Anti-atherosclerosis Formulation. Natural Antiatherosclerosis Formulation of demonstrated exceptionally huge (P <0.001) clot lytic properties in different blood samples. The percent clot lytic activity was compared with negative control (water) and standard enzyme positive control (streptokinase). The mean % of clot lysis for water and streptokinase was discovered 4.71% and 86.21% individually. Then again the mean percent clot lytic activity of Herbal Anti-atherosclerosis Formulation was discovered 29.51%, which is huge contrast and the positive and negative control. The present research recommends that Herbal Anti-atherosclerosis Formulation has significant thrombolytic action. Consequently the detailing may be a wellspring of powerful natural medication

Antioxidant potential, subacute toxicity, and beneficiary effects of methanolic extract of pomelo (Citrus grandis L. Osbeck) in Long Evan rats

The aim of this study was to investigate the antioxidant potentials, subacute toxicity, and beneficiary effects of methanolic extract of pomelo ( L. Osbeck) in rats. Long Evans rats were divided into four groups of eight animals each. The rats were orally treated with three doses of pomelo (250, 500, and 1000 mg/kg) once daily for 21 days. Pomelo extract contained high concentrations of polyphenols, flavonoids, and ascorbic acid while exhibiting high 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity and ferric reducing antioxidant power values. There was no significant change in the body weight, percentage water content, and relative organ weight at any administered doses. In addition, no significant alterations in the hematological parameters were also observed. However, rats which received 1000 mg/kg dose had a significant reduction in some serum parameters, including alanine transaminase (15.29%), alkaline phosphatase (2.5%), lactate dehydrogenase (15.5%), -glutamyltransferase (20%), creatinine (14.47%), urea (18.50%), uric acid (27.14%), total cholesterol (5.78%), triglyceride (21.44%), low-density lipoprotein cholesterol (40.74%), glucose (2.48%), and all atherogenic indices including cardiac risk ratio (24.30%), Castelli's risk index-2 (45.71%), atherogenic coefficient (42%), and atherogenic index of plasma (25%) compared to control. In addition, the highest dose (1000 mg/kg) caused a significant increase in iron (12.07%) and high-density lipoprotein cholesterol (8.87%) levels. Histopathological findings of the vital organs did not indicate any pathological changes indicating that pomelo is nontoxic, safe, and serves as an important source of natural antioxidants. In addition, the fruit extract has the potential to ameliorate hepato- and nephrotoxicities and cardiovascular diseases as well as iron deficiency anemia