Gamma-Ray Burst Polarimeter - GAP - aboard the Small Solar Power Sail Demonstrator IKAROS

The small solar power sail demonstrator "IKAROS" is a Japanese engineering verification spacecraft launched by H-IIA rocket on May 21, 2010 at JAXA Tanegashima Space Center. IKAROS has a huge sail with 20 m in diameter which is made of thin polyimide membrane. This sail converts the solar radiation-pressure into the propulsion force of IKAROS and accelerates the spacecraft. The Gamma-Ray Burst Polarimeter (GAP) aboard IKAROS is the first polarimeter to observe the gamma-ray polarization of Gamma-Ray Bursts (GRBs) during the IKAROS cruising phase. GAP is a tinny detector of 3.8 kg in weight and 17 cm in size with an energy range between 50-300 keV. The GAP detector also plays a role of the interplanetary network (IPN) to determine the GRB direction. The detection principle of gamma-ray polarization is the anisotropy of the Compton scattering. GAP works as the GRB polarimeter with the full coincidence mode between the central plastic and the surrounding CsI detectors. GAP is the first instrument, devoted for the observation of gamma-ray polarization in the astronomical history. In this paper, we present the GAP detector and its ground and onboard calibrations.Comment: Submitted to Publications of the Astronomical Society of Japan (PASJ), 23 pages, 14 figure

Serum levels of free light chain before and after chemotherapy in primary systemic AL amyloidosis

This is an electronic version of an article published in AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS. 13: 71(2006) [AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS] is available online at: http://www.informaworld.com/openurl?genre=article&issn=1350-6129&volume=13&issue=3&spage=71ArticleAmyloid-Journal of Protein Folding Disorders. 13(Suppl. 1): 45-45 (2006)journal articl

Design and performance of the muon monitor for the T2K neutrino oscillation experiment

This article describes the design and performance of the muon monitor for the T2K (Tokaito-Kamioka) long baseline neutrino oscillation experiment. The muon monitor consists of two types of detector arrays: ionization chambers and silicon PIN photodiodes. It measures the intensity and profile of muons produced, along with neutrinos, in the decay of pions. The measurement is sensitive to the intensity and direction of the neutrino beam. The linearity and stability of the detectors were measured in beam tests to be within 2.4% and 1.5%, respectively. Based on the test results, the precision of the beam direction measured by the muon monitor is expected to be 0.25 mrad.Comment: 22 page

Strict Limit on CPT Violation from Polarization of Gamma-Ray Bursts

We report the strictest observational verification of CPT invariance in the photon sector, as a result of gamma-ray polarization measurement of distant gamma-ray bursts (GRBs), which are brightest stellar-size explosions in the universe. We detected the gamma-ray polarization of three GRBs with high significance, and the source distances may be constrained by a well-known luminosity indicator for GRBs. For the Lorentz- and CPT-violating dispersion relation E_{\pm}^2=p^2 \pm 2\xi p^3/M_{Pl}, where \pm denotes different circular polarization states of the photon, the parameter \xi is constrained as |\xi|<O(10^{-15}). Barring precise cancellation between quantum gravity effects and dark energy effects, the stringent limit on the CPT-violating effect leads to the expectation that quantum gravity presumably respects the CPT invariance.Comment: 4 pages; accepted for publication in Physical Review Letters; redshift estimates of GRBs changed (i.e z=0.382 was wrong for GRB 110721A) and calculations of \xi limit improved from the previous versio

Development and operational experience of magnetic horn system for T2K experiment

A magnetic horn system to be operated at a pulsed current of 320 kA and to survive high-power proton beam operation at 750 kW was developed for the T2K experiment. The first set of T2K magnetic horns was operated for over 12 million pulses during the four years of operation from 2010 to 2013, under a maximum beam power of 230 kW, and $6.63\times10^{20}$ protons were exposed to the production target. No significant damage was observed throughout this period. This successful operation of the T2K magnetic horns led to the discovery of the $\nu_{\mu}\rightarrow\nu_e$ oscillation phenomenon in 2013 by the T2K experiment. In this paper, details of the design, construction, and operation experience of the T2K magnetic horns are described.Comment: 22 pages, 40 figures, also submitted to Nuclear Instrument and Methods in Physics Research,

Bipolar-Hyper-Shell Galactic Center Statrburst Model: Further Evidence from ROSAT Data and New Radio and X-ray Simulations

Using the all-sky ROSAT soft X-ray and 408-MHz radio continuum data, we show that the North Polar Spur and its western and southern counter-spurs draw a giant dumbbell-shape necked at the galactic plane. We interpret these features as due to a shock front originating from a starburst 15 million years ago with a total energy of the order of $\sim 10^{56}$ ergs or $10^5$ type II supernovae. We simulate all-sky distributions of radio continuum and soft X-ray intensities based on the bipolar-hyper-shell galactic center starburst model. The simulations can well reproduce the radio NPS and related spurs, as well as radio spurs in the tangential directions of spiral arms. Simulated X-ray maps in 0.25, 0.75 and 1.5 keV bands reproduce the ROSAT X-ray NPS, its western and southern counter-spurs, and the absorption layer along the galactic plane. We propose to use the ROSAT all-sky maps to probe the physics of gas in the halo-intergalactic interface, and to directly date and measure the energy of a recent Galactic Center starburst.Comment: To appear in ApJ, Latex MS in ApJ macro, 8 figures in jpg (original quality ps figs available on request

Myeloid progenitors with PTPN11 and nonRAS pathway gene mutations are refractory to treatment with 6-mercaptopurine in juvenile myelomonocytic leukemia

advance online publication, February 25, 2014Juvenile myelomonocytic leukemia (JMML) is a fatal, mixed myeloproliferative and myelodysplastic disorder occurring in infancy and early childhood. Children with JMML have mutually exclusive genetic abnormalities in granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathways, inactivation of the NF1 or mutations in PTPN11, NRAS, KRAS and CBL. A whole-exome sequencing study, performed by Sakaguchi et al.,3 has recently demonstrated that in addition to the high frequency of RAS pathway mutations, mutations in SETBP1 and JAK3 are common recurrent secondary events, and that these events may be involved in tumor progression, and are associated with poor clinical outcomes.ArticleLEUKEMIA. 28(7):1545-1548 (2014)journal articl